Methylperillat | 54298-90-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Methylperillat
• 英文别名: methyl 4-prop-1-en-2-ylcyclohexene-1-carboxylate
• CAS: 54298-90-7
• 化学式: C₁₁H₁₆O₂
• mdl: MFCD00216664
• 分子量: 180.247
• InChiKey: JMMLJZJUVKEVCK-UHFFFAOYSA-N

物化性质

• 沸点：
  68-72 °C0.04 mm Hg(lit.)
• 密度：
  0.999 g/mL at 25 °C(lit.)
• 闪点：
  >230 °F
• 保留指数：
  1350

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.545
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Methylperillat 、 1-氯甲氧基-2-丙烯 生成 7-(2-Allyloxy-ethyl)-7-methyl-bicyclo[4.1.0]hept-2-ene-3-carboxylic acid methyl ester
  参考文献：
  名称：

  萜类化合物的合成。三，氯甲基醚在烯烃的羟甲基化反应中的合成

  摘要：

  DOI：

  10.1016/s0040-4039(00)91328-5

文献信息

• THERAPEUTIC USES OF OLIGOMERIC AND POLYMERIC MONOTERPENES
  申请人：Hazan Zadik

  公开号：US20120213727A1

  公开（公告）日：2012-08-23

  The invention relates to therapeutic methods comprising use of oligomeric and polymeric forms of the monoterpene compounds alloocimene, limonene, alpha-pinene, beta-pinene, geranyl acetate, alpha-phellandrene, gamma-terpinene, 3-carene and 2-carene. More particularly, the invention relates to methods of treating degenerative neurological conditions, and treating skin disorders.

  本发明涉及使用单萜化合物alloocimene、limonene、alpha-pinene、beta-pinene、geranyl acetate、alpha-phellandrene、gamma-terpinene、3-carene和2-carene的寡聚体和聚合体形式的治疗方法。更具体地，本发明涉及治疗退行性神经疾病和治疗皮肤疾病的方法。
• PERILLIC ACID DERIVATIVE, METHOD FOR PREPARING A PERILLIC ACID DERIVATIVE, PHARMACEUTICAL COMPOSITION, USE OF A PERILLIC ACID DERIVATIVE AND CANCER TREATMENT METHOD
  申请人：Fundação Oswaldo Cruz

  公开号：EP3184503A1

  公开（公告）日：2017-06-28

  The present invention provides a compound of perillic acid in the form of a salt, having Formula II, exhibiting anti-cancer activity, where counterion M+ comprises alkaline or alkaline earth metals, such as Na+ (sodium), K+ (potassium), Ca+2/2 (calcium), etc. The invention further discloses a method of obtaining the compound, a pharmaceutical composition, use of the compound and a method of treating cancer.

  本发明提供了一种具有式 II 的盐形式的过硫酸化合物，具有抗癌活性，其中反离子 M+ 包括碱金属或碱土金属，如 Na+（钠）、K+（钾）、Ca+2/2（钙）等。 本发明进一步公开了一种获得该化合物的方法、一种药物组合物、该化合物的用途和一种治疗癌症的方法。
• Monoterpene compositions and uses thereof
  申请人：Constantinides P Panayiotis

  公开号：US20060104997A1

  公开（公告）日：2006-05-18

  The present invention relates to pharmaceutical compositions and methods for the mucosal and oral administration of monoterpenes and derivatives thereof. The compositions of this invention further comprise one or more surfactants and cosolvents and are in the form of self-emulsifying compositions. The compositions of the invention may further comprise water-insoluble therapeutic agents, vaccines and diagnostics. Such agents include but are not limited to taxanes, steroids, topoisomerase inhibitors such as etoposide and other water-insoluble or lipophilic drugs.

  本发明涉及粘膜和口服单萜及其衍生物的药物组合物和方法。本发明的组合物进一步包含一种或多种表面活性剂和助溶剂，并采用自乳化组合物的形式。本发明的组合物可进一步包含水不溶性治疗剂、疫苗和诊断剂。这类药剂包括但不限于类固醇、类固醇、拓扑异构酶抑制剂（如依托泊苷）和其他不溶于水或亲脂性药物。
• USES OF PERILLYL ALCOHOL AND PERILLIC ACID METHYL ESTER
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：EP0750497A1

  公开（公告）日：1997-01-02
• POLYMERIC MONOTERPENES FOR TREATING IMPAIRED NEUROLOGICAL FUNCTION
  申请人：Regenera Pharma Ltd.

  公开号：EP2493461B1

  公开（公告）日：2016-01-06