[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] carbamate | 38911-83-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] carbamate
• CAS: 38911-83-0
• 化学式: C₁₆H₂₇NO₂
• 分子量: 265.39
• InChiKey: RGEVSODOJCOAMD-YFVJMOTDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• US4520029A
  申请人：——

  公开号：US4520029A

  公开（公告）日：1985-05-28
• [EN] THERAPEUTIC USES FOR GERANYLGERANYL ACETONE AND DERIVATIVES THEREOF<br/>[FR] UTILISATIONS THERAPEUTIQUES DE GERANYLGERANYLE ACETONE ET DE SES DERIVES
  申请人：COYOTE PHARMACEUTICALS INC

  公开号：WO2014151697A1

  公开（公告）日：2014-09-25

  Provided herein are compositions, including intranasal compositions, which include geranylgeranyl acetone (GGA) and/or derivatives thereof and methods for treating a neural disease, disorder or condition with the same. Also provided herein are methods of treating inflammatory bowel disease with geranylgeranyl acetone (GGA) and/or derivatives thereof. Further provided are methods of treating chronic liver disease (CLD) with geranylgeranyl acetone (GGA) and/or derivatives thereof. Still further are provided methods for treating other hepatic and cardiac disorders.
• [EN] SUBLINGUAL FORMULATIONS INCLUDING GERANYLGERANYLACETONE AND GERANYLGERANYLACETONE DERIVATIVES<br/>[FR] FORMULATIONS SUBLINGUALES COMPRENANT DE LA GÉRANYLGÉRANYLACÉTONE ET DES DÉRIVÉS DE GÉRANYLGÉRANYLACÉTONE
  申请人：COYOTE PHARMACEUTICALS INC

  公开号：WO2014151719A1

  公开（公告）日：2014-09-25

  Provided herein are sublingual formulations of geranylgeranylacetone, geranylgeranylacetone derivatives, and drug conjugates of each thereof, and methods of using them. Also provided are methods for treating osteopenia with geranylgeranyl acetone (GGA) and derivatives thereof and compositions useful for the same. Also provided are polyisoprenyl phosphonate derivatives, pharmaceutical compositions comprising the polyisoprenyl phosphonate derivatives, and uses thereof.
• [EN] OCULAR FORMULATIONS<br/>[FR] FORMULATIONS OPHTALMIQUES
  申请人：COYOTE PHARMACEUTICALS INC

  公开号：WO2014151703A1

  公开（公告）日：2014-09-25

  Provided herein is a pharmaceutical formulation comprising a GGA or GGA derivatives, including a physical mixture of GGA or a GGA derivative, and a drug, or drug conjugates of GGA or GGA derivatives. Also provided herein are methods for the intraocular or systemic delivery and of the pharmaceutical formulations and methods of treating ocular diseases or disorders by administering such pharmaceutical formulations onto the surface of the eye.