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4-hydroxy-3-methoxyphenyl 2-thiazolyl ketone | 110281-33-9

中文名称
——
中文别名
——
英文名称
4-hydroxy-3-methoxyphenyl 2-thiazolyl ketone
英文别名
(4-Hydroxy-3-methoxyphenyl)-(1,3-thiazol-2-yl)methanone
4-hydroxy-3-methoxyphenyl 2-thiazolyl ketone化学式
CAS
110281-33-9
化学式
C11H9NO3S
mdl
——
分子量
235.263
InChiKey
AQWKMWJVYREYAL-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.2
  • 重原子数:
    16
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.09
  • 拓扑面积:
    87.7
  • 氢给体数:
    1
  • 氢受体数:
    5

反应信息

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文献信息

  • 5-lipoxygenase inhibitory thiazoles
    申请人:ICI Pharma
    公开号:US05089513A1
    公开(公告)日:1992-02-18
    The invention concerns a thiazole of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted aryl of up to 10 carbon atoms; A is a direct link to X, or is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar.sup.2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms; R.sup.1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R.sup.2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, substituted (1-4C)alkyl or (2-6C)alkanoyl; Q is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said thiazole.
    该发明涉及一种式I的噻唑化合物,其中Ar.sup.1是最多含有10个碳原子的可选择取代的芳基;A是直接连接到X,或者是(1-6C)烷基,(3-6C)烯基,(3-6C)炔基或环(3-6C)烷基;X是氧,,亚基,磺酰基或亚胺基;Ar.sup.2是可选择取代的苯基,或者含有最多三个氮原子的6元杂环基;R.sup.1是氢,(1-6C)烷基,(2-6C)烯基,(2-6C)炔基或取代的(1-4C)烷基;R.sup.2是氢,(1-6C)烷基,(3-6C)烯基,(3-6C)炔基,取代的(1-4C)烷基或(2-6C)烷酰基;Q是可选择取代的噻唑基;或其药学上可接受的盐。该发明还涉及制备式I的噻唑化合物或其药学上可接受的盐的方法,以及含有该噻唑化合物的药物组合物。
  • Heterocyclic thiazole derivatives and pharmaceutical compositions
    申请人:Imperial Chemical Industries PLC
    公开号:US05089495A1
    公开(公告)日:1992-02-18
    The invention concerns a thiazole of the formula I, ##STR1## wherein Q.sup.1 is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents, or Ar is an optionally substituted 6-membered heterocyclene moiety continuing up to three nitrogen atoms; R.sup.1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R.sup.2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl or substituted (1-4C)alkyl or R.sup.2 is optionally substituted benzoyl; and Q.sup.2 is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I and pharmaceutical compositions containing said thiazole.
    这项发明涉及一种公式I的噻唑化合物,其中Q.sup.1是一个可选择取代的含有一个或两个氮原子的6元单环或10元双环杂环基团;X是氧、、亚基、磺酰基或亚胺基;Ar是苯基,可以选择携带一个或两个取代基,或者Ar是一个可选择取代的含有最多三个氮原子的6元杂环基团;R.sup.1是氢、(1-6C)烷基、(2-6C)烯基、(2-6C)炔基或取代的(1-4C)烷基;R.sup.2是氢、(1-6C)烷基、(3-6C)烯基、(3-6C)炔基或取代的(1-4C)烷基,或者R.sup.2是可选择取代的苯甲酰基;Q.sup.2是可选择取代的噻唑基;或其药学上可接受的盐。该发明还涉及一种制备公式I的噻唑化合物的方法和含有该噻唑化合物的药物组合物。
  • Thiazole derivatives having a 5-lipoxygenase-inhibiting activity
    申请人:IMPERIAL CHEMICAL INDUSTRIES PLC
    公开号:EP0351194B1
    公开(公告)日:1994-06-15
  • Heterocyclic derivatives
    申请人:IMPERIAL CHEMICAL INDUSTRIES PLC
    公开号:EP0381375B1
    公开(公告)日:1992-11-11
  • ARABSHAHI, LILI;SCHMITZ, FRANCIS J., TETRAHEDRON LETT., 29,(1988) N 10, 1099-1102
    作者:ARABSHAHI, LILI、SCHMITZ, FRANCIS J.
    DOI:——
    日期:——
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