8-Hydroxy-4-methoxychinaldinsaeure | 28027-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Hydroxy-4-methoxychinaldinsaeure
• 英文别名: 8-hydroxy-4-methoxyquinoline-2-carboxylic acid；4-methoxy-8-hydroxyquinoline-2-carboxylic acid；MHQC；quinolobactin
• CAS: 28027-14-7
• 化学式: C₁₁H₉NO₄
• 分子量: 219.197
• InChiKey: BBZLFYDYFRWHEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-Hydroxy-4-methoxychinaldinsaeure 在 碳酸氢钠 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 3-methylbut-2-enyl 8-(isopentyloxy)-4-methoxyquinoline-2-carboxylate
  参考文献：
  名称：

  Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities

  摘要：

  Mitochondrial uncoupling is one of the therapeutic strategies used to control energy metabolism in various metabolic diseases and in obesity. Ppc-1 (1), a prenylated quinolinecarboxylic acid isolated from cellular slime molds, shows uncoupling activity in vitro and anti-obesity activity in vivo. In this study, we synthesized Ppc-1 (1) and its derivatives, and revealed the structure-activity relationship of uncoupling activities. The triprenylated compound 18 showed mitochondrial uncoupling activity that was more potent than that of Ppc-1 (1). Compound 18 also suppressed weight gain in mice without undesired effects such as lesions on tissues. These results indicate that compound 18 could be used as a seed compound for new anti-obesity drugs. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.11.024
• 作为产物：
  描述：

  8-羟基-4-甲氧基喹啉-2-羧酸甲酯 在 水 、 sodium hydroxide 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 0.5h， 生成 8-Hydroxy-4-methoxychinaldinsaeure
  参考文献：
  名称：

  Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds

  摘要：

  We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.029

文献信息

• 一种治疗白内障药物苯并吩噁嗪类化合物及其制备方法
  申请人：日照市普达医药科技有限公司

  公开号：CN108558906A

  公开（公告）日：2018-09-21

  本发明提供了一种治疗白内障药物苯并吩噁嗪类化合物及其制备方法，所述治疗白内障药物苯并吩噁嗪类化合物具有如下化学结构式：，本发明提供的苯并吩噁嗪类化合物为散瞳药物，其类似虫眼黄素化合物，能与晶状体水溶性蛋白质有较强的亲和力，可竞争性抑制醌型物质对晶状体可溶性蛋白质的氧化、变性、混浊化作用，防止白内障的发展，对老年性白内障，糖尿病引起的白内障、外伤及先天性白内障、色素性视网膜炎均有良好的治疗效果，可以用于白内障疾病的深入研究与开发。
• Novel spirochromanone derivatives
  申请人：Yamakawa Takeru

  公开号：US20070021453A1

  公开（公告）日：2007-01-25

  The invention relates to a compound of a formula (I): or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.

  该发明涉及一种公式（I）的化合物，或其药学上可接受的盐或酯，用作治疗各种与ACC相关的疾病的治疗剂。
• SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS
  申请人：Yamakawa Takeru

  公开号：US20090131464A1

  公开（公告）日：2009-05-21

  The invention relates to a compound of a formula (I): or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.

  本发明涉及一种式(I)的化合物，或其药学上可接受的盐或酯，用作治疗各种与ACC相关的疾病的治疗剂。
• JP6348845
  申请人：——

  公开号：——

  公开（公告）日：——
• Neuenhaus, W.; Budzikiewicz, H.; Korth, H., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1980, vol. 35, # 12, p. 1569 - 1571
  作者：Neuenhaus, W.、Budzikiewicz, H.、Korth, H.、Pulverer, G.

  DOI：——

  日期：——