[4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
• 化学式: C₂₂H₃₀O₈
• 分子量: 422.5
• InChiKey: BDIAUFOIMFAIPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• PSEUDOAZULENYL NITRONES
  申请人：Becker David A.

  公开号：US20100016349A1

  公开（公告）日：2010-01-21

  Disclosed herein are pseudoazulenyl nitrone compounds and methods of using these compounds to trap free radicals and to treat, prevent, or ameliorate various diseases associated with free radicals.

  本文公开了伪蒽基硝酮化合物及其使用这些化合物捕获自由基以及治疗、预防或缓解与自由基相关的各种疾病的方法。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Hair dyeing
  申请人：TOKIWA KANPO PHARMACEUTICAL CO., LTD.

  公开号：EP0440494A2

  公开（公告）日：1991-08-07

  An iridoid glycoside, or an aglycone thereof, is used to dye hair, and for the manufacture of a cosmetic for dyeing hair.

  鸢尾甙或其苷元可用于染发和制造染发化妆品。
• Treatment of spasticity, convulsions by isovaleric acid derivatives CNS depressants
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1516619A2

  公开（公告）日：2005-03-23

  Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and its pharmaceutically acceptable salts, esters, and substituted amides, exhibit clinically significant pharmacological properties which implicate a treatment for a variety of pathological conditions, including spasticity and convulsions, which are ameliorated by effecting a mild depression of CNS activity. The compositions in question generally are non-cytotoxic and do not elicit weakness or seductive activity at doses that are effective for the symptomatic treatment of such pathological conditions.

  缬草的制剂和提取物以及异戊酰胺、异戊酸及其药学上可接受的盐、酯和取代酰胺具有显著的临床药理特性，可用于治疗各种病症，包括痉挛和抽搐，这些病症可通过轻度抑制中枢神经系统的活性而得到改善。这些成分一般不具有细胞毒性，在对症治疗此类病症有效的剂量下，不会引起虚弱或诱导性活动。
• Composition comprising isovaleramide and ibuprofen
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1576962A1

  公开（公告）日：2005-09-21

  Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and its pharmaceutically acceptable salts, esters, and substituted amides, and other valerian-related compounds, in combination with NSAIDs exhibit clinically significant pharmacological properties which implicate a treatment for acute muscular aches, strains, and sprains which occur from a localized, external insult to a particular muscle or muscle group outside of, or peripheral to, the CNS. The compositions in question generally are non-cytotoxic and do not elicit weakness or sedative activity at doses that are effective for the symptomatic treatment of such pathological conditions.

  缬草的制剂和提取物，以及异戊酰胺、异戊酸及其药学上可接受的盐、酯和取代酰胺，以及其他与缬草有关的化合物，与非甾体抗炎药结合使用，具有显著的临床药理特性，可用于治疗急性肌肉酸痛、拉伤和扭伤，这些症状是由于中枢神经系统以外或外周的特定肌肉或肌肉群受到局部的外部损伤而引起的。这些成分一般不具有细胞毒性，在对症治疗此类病症有效的剂量下，不会引起虚弱或镇静作用。