LY 367265 | 210751-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: LY 367265
• 英文别名: SS58Uxz8ZU；3-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-2λ6-thia-1,3-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-triene 2,2-dioxide
• CAS: 210751-39-6
• 化学式: C₂₄H₂₅FN₄O₂S
• 分子量: 452.553
• InChiKey: BJIPVHLRWSDKOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  LY 367265 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Novel chemoselective reduction of the tetrahydro-4-pyridyl versus indole moiety governed by electron donation: first X-ray evidence for indolopiperidyl–borane complexation

  摘要：

  A series of amino-borane complexes of structure type 2 are the key intermediates in the preparation of 3-(piperidyl) indole derivatives. The selective reduction of the tetrahydro-4-pyridyl double bond via 2 under strongly acidic conditions is feasible only when the pyridyl double bond is conjugated with electron rich substituents, such as indoles. This reduction methodology allows the presence of reducible and hydrogenolizable functional groups. An improved process to prepare 2 by treatment of the 3-(tetrahydro-4-pyridyl) indole derivatives with NaBH4 in THF under acidic conditions (AcOH or CF3COOH) is also described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01927-5

文献信息

• ARYLPIPERAZINE-CONTAINING PURINE DERIVATIVES AND USES THEREOF
  申请人：Lee Jinhwa

  公开号：US20120232090A1

  公开（公告）日：2012-09-13

  A novel arylpiperazine-containing purine derivatives and a pharmaceutical composition comprising the same as an active ingredient, which are useful for preventing or treating depressive disorders, are provided.

  一种含有芳基哌嗪的嘌呤衍生物以及包含其作为活性成分的药物组合物被提供，用于预防或治疗抑郁症。
• PHARMACEUTICAL COMPOUNDS
  申请人：——

  公开号：US20010053783A1

  公开（公告）日：2001-12-20

  A pharmaceutical compound of the formula 1 in which R 1 is hydrogen, C 1-4 alkyl, C 1-4 alkoxy or halo, and R 2 is hydrogen, C 1-4 alkyl or C 1-4 alkoxy; or a salt thereof.

  一个化学配方的药物化合物，其中R1是氢、C1-4烷基、C1-4烷氧基或卤素，R2是氢、C1-4烷基或C1-4烷氧基；或其盐。
• NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Lee Jinhwa

  公开号：US20120115881A1

  公开（公告）日：2012-05-10

  A novel arylpiperazine-containing imidazole 4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a depressive disorder are provided.

  本发明提供了一种新的含有芳基哌嗪基的咪唑-4-羧酰胺衍生物或其药学上可接受的盐，并且提供了一种以其为活性成分的制药组合物，用于预防或治疗抑郁症。
• Substituted 4-(6-fluoro-[1H]-indol-3-yl)-1,2,3,6-tetrahydropyridine for the treatment of CNS-disorders
  申请人：ELI LILLY AND COMPANY LIMITED

  公开号：EP0854146A1

  公开（公告）日：1998-07-22

  A pharmaceutical compound of the formula in which R1 is hydrogen, C1-4 alkyl, C1-4 alkoxy or halo, and R2 is hydrogen, C1-4 alkyl or C1-4 alkoxy; or a salt thereof. The compounds of the invention and their pharmaceutically acceptable salts are indicated for use in the treatment of disorders of the central nervous system.

  式中 R1 为氢、C1-4 烷基、C1-4 烷氧基或卤代 其中 R1 为氢、C1-4 烷基、C1-4 烷氧基或卤代，R2 为氢、C1-4 烷基或 C1-4 烷氧基；或其盐。 本发明的化合物及其药学上可接受的盐可用于治疗中枢神经系统疾病。
• COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS
  申请人：Consejo Superior de Investigaciones Científicas (CSIC)

  公开号：EP3713568A1

  公开（公告）日：2020-09-30