cubebin | 1217727-78-0

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 呋喃类木脂素
• 英文名称: cubebin
• 英文别名: 3,4-bis(1,3-benzodioxol-5-ylmethyl)oxolan-2-ol
• CAS: 1217727-78-0
• 化学式: C₂₀H₂₀O₆
• 分子量: 356.375
• InChiKey: DIYWRNLYKJKHAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 cubebin 以 吡啶 为溶剂， 生成 Acetic acid 3,4-bis-benzo[1,3]dioxol-5-ylmethyl-tetrahydro-furan-2-yl ester
  参考文献：
  名称：

  Habib; El-Sebakhy, Pharmazie, 1981, vol. 36, # 4, p. 291 - 294

  摘要：

  DOI：

文献信息

• CUBEBIN, DIBENZYLBUTYROLACTONE LIGNAN, SEMI-SYNTHETIC AND SYNTHETIC DERIVATIVES THEREOF, AND OTHER LIGNANS AND NEOLIGNANS AS VASODILATING AGENTS IN THE THERAPY OF ERECTILE DYSFUNCTION
  申请人：ACEF S/A

  公开号：EP2517705A1

  公开（公告）日：2012-10-31

  Described and disclosed is the use of cubebin, a dibenzylbutyrolactone lignan, of the semisynthetic and synthetic derivatives thereof, and of other lignans and neolignans for the treatment of erectile dysfunction.

  所描述和公开的是立方宾（一种二苄基丁内酯木质素）、其半合成和合成衍生物以及其他木质素和新木质素在治疗勃起功能障碍方面的用途。
• KIT FOR TOOTH WHITENING COMPRISING AN ORAL COMPOSITION, A DELIVERY CARRIER AND AN ELECTROMAGNETIC RADIATION SOURCE
  申请人：The Procter & Gamble Company

  公开号：EP3315119A1

  公开（公告）日：2018-05-02

  The present invention relates to a kit for whitening teeth comprising a delivery carrier and a multi-phase oral composition for whitening teeth in form of a water-in-oil emulsion as well as an electromagnetic radiation source capable of directing electromagnetic radiation with one or more wavelength in the range from 200 to 1700nm toward at least one tooth. The oral compositions comprises from about 0.002% to about 5% by weight of an aqueous phase; a predominant proportion of a hydrophobic phase; at least one oral care active agent in the aqueous, phase, wherein the active agent is a bleaching agent and the final concentration of the bleaching agent is up to 0.1% by weight of the oral composition. The present invention also relates to the use of the kit for whitening teeth and/or removing stain from tooth surfaces as well as to a method of whitening teeth, removing stain from tooth surfaces or both. The use and the method are based on the kit presented herein.

  本发明涉及一种用于美白牙齿的试剂盒，该试剂盒包括一种输送载体和一种油包水型乳液形式的多相美白牙齿口服组合物，以及一种能够将波长在200至1700纳米范围内的一种或多种电磁辐射导向至少一颗牙齿的电磁辐射源。口腔组合物包括按重量计约 0.002%至约 5%的水相；主要比例的疏水相；水相中至少一种口腔护理活性剂，其中活性剂为漂白剂，漂白剂的最终浓度按口腔组合物重量计最高为 0.1%。 本发明还涉及该套装在美白牙齿和/或去除牙齿表面污渍方面的用途，以及美白牙齿、去除牙齿表面污渍或两者兼而有之的方法。本发明的用途和方法均基于本发明中介绍的试剂盒。
• MULTI-PHASE ORAL COMPOSITION FOR TOOTH WHITENING
  申请人：The Procter & Gamble Company

  公开号：EP3315172A1

  公开（公告）日：2018-05-02

  The present invention relates to a multi-phase oral composition for whitening teeth preferably comprising a water-in-oil emulsion. The oral compositions comprises from about 0.002% to about 5% by weight of an aqueous phase; a predominant proportion of a hydrophobic phase; at least one oral care active agent in the aqueous, phase, wherein the active agent is a bleaching agent and the ratio of the bleaching agent in the aqueous phase to the net concentration of the bleaching agent in the oral composition is at least 20. The present invention also relates to the use of the oral composition for whitening teeth and/or removing stain from tooth surfaces as well as to a method of whitening teeth, removing stain from tooth surfaces or both. The use and the method are based on the oral composition presented herein.

  本发明涉及一种用于美白牙齿的多相口腔组合物，该组合物最好由油包水乳液组成。该口服组合物包括按重量计约 0.002%至约 5%的水相；主要比例的疏水相；水相中至少一种口腔护理活性剂，其中活性剂是漂白剂，水相中漂白剂与口服组合物中漂白剂净浓度之比至少为 20。 本发明还涉及口服组合物用于美白牙齿和/或去除牙齿表面污渍的用途，以及美白牙齿、去除牙齿表面污渍或两者兼而有之的方法。本发明的用途和方法均基于本发明的口服组合物。
• ORAL COMPOSITION FOR DELIVERING ORAL CARE ACTIVE AGENTS
  申请人：The Procter & Gamble Company

  公开号：EP3315117A1

  公开（公告）日：2018-05-02

  The present invention relates to a multi-phase oral composition for delivering active agent(s) and their benefits to teeth and the oral cavity, preferably comprising a water-in-oil emulsion. The oral compositions comprises from about 0.01% to about 5% by weight of an aqueous phase; a predominant proportion of a hydrophobic phase and at least one oral care active agent in the aqueous phase, wherein the final concentration of the active agent is up to 0.1% by weight of the oral composition. The present invention also relates to the use of the oral composition and a method of delivering active agent(s) and their benefits to teeth and the oral cavity. The use and the method are based on the oral composition presented herein.

  本发明涉及一种多相口腔组合物，用于向牙齿和口腔输送活性剂及其益处，最好包括油包水型乳液。该口腔组合物包括按重量计约 0.01%至约 5%的水相；在水相中占主要比例的疏水相和至少一种口腔护理活性剂，其中活性剂的最终浓度按口腔组合物重量计最高为 0.1%。 本发明还涉及口腔组合物的用途以及向牙齿和口腔输送活性剂及其益处的方法。该用途和方法以本文介绍的口服组合物为基础。
• KIT FOR TOOTH WHITENING COMPRISING AN ORAL COMPOSITION AND A DELIVERY CARRIER
  申请人：The Procter & Gamble Company

  公开号：EP3315118A1

  公开（公告）日：2018-05-02

  The present invention relates to a kit for whitening teeth comprising a delivery carrier and a multi-phase oral composition for whitening teeth in form of a water-in-oil emulsion. The oral compositions comprises from about 0.002% to about 5% by weight of an aqueous phase; a predominant proportion of a hydrophobic phase; at least one oral care active agent in the aqueous, phase, wherein the active agent is a bleaching agent and the final concentration of the bleaching agent is up to 0.1% by weight of the oral composition. The present invention also relates to the use of the kit for whitening teeth and/or removing stain from tooth surfaces as well as to a method of whitening teeth, removing stain from tooth surfaces or both. The use and the method are based on the kit presented herein.

  本发明涉及一种用于美白牙齿的试剂盒，包括一种输送载体和一种油包水型乳液形式的多相美白牙齿口服组合物。该口服组合物包括按重量计约 0.002%至约 5%的水相；占主要比例的疏水相；水相中至少一种口腔护理活性剂，其中活性剂为漂白剂，漂白剂的最终浓度按口服组合物重量计最高为 0.1%。 本发明还涉及该套装在美白牙齿和/或去除牙齿表面污渍方面的用途，以及美白牙齿、去除牙齿表面污渍或两者兼而有之的方法。本发明的用途和方法均基于本发明中介绍的试剂盒。