4-hydroxy-5a,9-dimethyl-3-methylidene-4,5,6,7,8,9b-hexahydro-3aH-benzo[g][1]benzofuran-2-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-hydroxy-5a,9-dimethyl-3-methylidene-4,5,6,7,8,9b-hexahydro-3aH-benzo[g][1]benzofuran-2-one
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.32
• InChiKey: GFTABBWAVCHCRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] 7-HYDROXYFRULLANOLIDE AND ITS ANALOGS FOR PREVENTION, CONTROL AND TREATMENT OF METABOLIC DISORDERS<br/>[FR] 7-HYDROXYFRULLANOLIDE ET SES ANALOGUES POUR LA PRÉVENTION, LA MAÎTRISE ET LE TRAITEMENT DE TROUBLES DU MÉTABOLISME.
  申请人：LAILA NUTRACEUTICALS

  公开号：WO2012014216A1

  公开（公告）日：2012-02-02

  The invention discloses biologically active ingredient(s) selected from 7- hydroxyfrullanolide, its analogs, the extract(s) and fraction(s) standardized to 7- hydroxyfrullanolide or its analogs or both or mixtures thereof or their composition(s) for the prevention, control and treatment of one or more obesity, overweight, metabolic syndrome, diabetes and other metabolic disorders or for producing lean body mass in a warm blooded animal in need thereof.

  本发明揭示了从7- 羟基富尔醛内酯、其类似物、提取物和分离物中选择的生物活性成分，这些成分经标准化处理得到7- 羟基富尔醛内酯或其类似物或两者或二者的混合物，或它们的组合物，用于预防、控制和治疗一种或多种肥胖、超重、代谢综合征、糖尿病和其他代谢紊乱，或用于在需要的温血动物中产生瘦体重。
• COMPOSITION FROM SPHAERANTHUS INDICUS AND GARCINIA MANGOSTANA FOR THE CONTROL OF METABOLIC SYNDROME
  申请人：Laila Nutraceuticals

  公开号：EP2391374A2

  公开（公告）日：2011-12-07
• [EN] COMPOSITION FROM SPHAERANTHUS INDICUS AND GARCINIA MANGOSTANA FOR THE CONTROL OF METABOLIC SYNDROME<br/>[FR] COMPOSITION PROVENANT DE SPHAERANTHUS INDICUS ET DE GARCINIA MANGOSTANA POUR MAÎTRISER LE SYNDROME MÉTABOLIQUE
  申请人：LAILA NUTRACEUTICALS

  公开号：WO2010100653A2

  公开（公告）日：2010-09-10

  The invention relates pharmaceutical/dietary supplement/food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Sphaeranthus indicus and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.
• [EN] SPHAERANTHUS INDICUS COMPOSITION AS IL-17 INHIBITOR AND USES THEREOF<br/>[FR] COMPOSITION DE SPHAERANTHUS INDICUS EN TANT QU'INHIBITEUR DE L'IL-17 ET SES UTILISATIONS
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2016020724A1

  公开（公告）日：2016-02-11

  The present invention relates to herbal composition comprising an extract of the flowering and fruiting heads of the plant Sphaeranthus indicus as interleukin-17 (IL-17) inhibitor. Further, the invention relates to the use of the said herbal composition for the treatment of disorders mediated by IL-17.