2(5H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2(5H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
• 英文别名: 4-[2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one
• 化学式: C₂₀H₃₀O₄
• 分子量: 334.4
• InChiKey: GVRNTWSGBWPJGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Treatment of Alzheimer's and Cognitive Impairment With Andrographolides
  申请人：INNOBIOSCIENCE, LLC

  公开号：US20150352075A1

  公开（公告）日：2015-12-10

  We found that Andrographolide binds to GSK-3β: In so doing, andrographolide prevents changes in neuropathology in an Alzheimer's model, reducing Amyloid-β peptide levels, changing the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-β. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may be used to treat Alzheimer's disease.
• Hippocampus Regeneration And Memory Recovery
  申请人：INNOBIOSCIENCE, LLC

  公开号：US20220409573A1

  公开（公告）日：2022-12-29

  We found that Andrographolide binds to GSK-3β: In so doing, andrographolide changies the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-β. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may he used to heal patients with a damaged hippocampus and recover memory loss in such patients.
• [EN] TREATMENT OF ALZHEIMER'S AND COGNITIVE IMPAIRMENT WITH ANDROGRAPHOLIDES<br/>[FR] TRAITEMENT DE LA MALADIE D'ALZHEIMER ET D'ATTEINTES COGNITIVES AU MOYEN D'ANDROGRAPHOLIDES
  申请人：INNOBIOSCIENCE LLC

  公开号：WO2014176149A1

  公开（公告）日：2014-10-30

  Andrographolide binds to GSK-3Beta, preventing changes in neuropathology in an Alzheimer's model, reducing Amyloid-Beta peptide levels, changing the ontogeny of hippocampus and cortex amyloid plaques, and reducing tau phosphorylation around Amyloid-Beta. Andrographolide recovers spatial memory functions in an Alzheimer's model. Andrographolide and its derivatives may be used to treat Alzheimer's disease.
• [DE] KOSMETISCHE ODER DERMATOLOGISCHE ZUBEREITUNGEN MIT EINEM GEHALT AN DECALINDERIVATEN UND VERWENDUNG VON DECALINDERIVATEN ZUR BRÄUNUNG DER HAUT<br/>[EN] COSMETIC OR DERMATOLOGICAL PREPARATIONS HAVING A CONTENT OF DECALINE DERIVATIVES AND USE OF DECALINE DERIVATIVES FOR TANNING THE SKIN<br/>[FR] PRÉPARATIONS COSMÉTIQUES OU DERMATOLOGIQUES CONTENANT DES DÉRIVÉS DE DÉCALINE ET UTILISATION DE DÉRIVÉS DE DÉCALINE POUR LE BRONZAGE DE LA PEAU
  申请人：BEIERSDORF AG

  公开号：WO2015135606A1

  公开（公告）日：2015-09-17

  Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an einem oder mehreren Decalinderivaten und Verwendung von einem oder mehreren Decalinderivaten zur Herstellung kosmetischer Zubereitungen zur Bräunung der Haut.