2-[2-[2,6-dimethyl-8-(2,6,6-trimethylcyclohexen-1-yl)octa-1,3,5,7-tetraenyl]-4-[4-methyl-6-(2,6,6-trimethylcyclohexen-1-yl)hexa-1,3,5-trienyl]-2H-pyridin-1-yl]ethanol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[2-[2,6-dimethyl-8-(2,6,6-trimethylcyclohexen-1-yl)octa-1,3,5,7-tetraenyl]-4-[4-methyl-6-(2,6,6-trimethylcyclohexen-1-yl)hexa-1,3,5-trienyl]-2H-pyridin-1-yl]ethanol
• 化学式: C₄₂H₅₉NO
• 分子量: 593.9
• InChiKey: IOZOQXBAIOAOPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] ANTHOCYANIN COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSES ANTHOCYANINIQUES ET PROCEDES D'UTILISATION CORRESPONDANTS
  申请人：UNIV COLUMBIA

  公开号：WO2005077176A1

  公开（公告）日：2005-08-25

  The present invention is directed to methods for treating or preventing eye diseases or disorders, such as macular degeneration, by administering one or more anthocyanins and/or Anthocyanin Derivatives. These methods are based in part on the present findings that anthocyanins can prevent and/or reduce cell death and damage induced by a byproduct of the visual cycle, A2E. Thus, the present invention provides methods for identifying particular anthocyanins and Anthocyanin Derivatives that are effective for treating or preventing eye diseases or disorders, and compositions comprising Anthocyanin Derivatives and specific mixtures of anthocyanins. The present invention also provides anthocyanin and/or anthocyanin derivative-based therapeutic compositions and methods that involve specific effects against A2E-mediated cellular damage. Methods are also provided which identify the anthocyanins and Anthocyanin Derivatives that can prevent or reduce A2E-mediated cellular damage, and the dose amount and formulations that provide such therapeutic effects.