Gold-Oxazoline Complex-Catalyzed Cross-Dehydrogenative Coupling of Glycine Derivatives and Alkenes
作者:Minjie Ni、Yan Zhang、Tingting Gong、Bainian Feng
DOI:10.1002/adsc.201601066
日期:2017.3.6
A gold‐oxazoline complex‐catalyzeddehydrogenative Povarov/oxidation tandem reaction for the synthesis of decorated quinolines has been developed from glycine derivatives and alkenes. The reaction performs under mild reaction conditions in the presence of oxygen as the oxidant and features a broad substrate scope and excellent functional group tolerance.
AbstractA novel CBr4‐mediated dehydrogenative Povarov/aromatization tandem reaction of glycine derivatives with alkenes, leading to complex quinoline derivatives, and a CBr4‐mediated dehydrogenative CH functionalization of N‐aryl tetrahydroisoquinolines with nucleophiles to form CC and CP bonds are reported. The reactions were performed under very simple and mild reaction conditions; only CBr4 was used as a promoter. A plausible mechanism involving a radical process is proposed.
An Efficient Route to Quinolines and Other Compounds by Iron-Catalysed Cross-Dehydrogenative Coupling Reactions of Glycine Derivatives
作者:Peng Liu、Zhiming Wang、Jue Lin、Xianming Hu
DOI:10.1002/ejoc.201101656
日期:2012.3
A simple method has been developed for functionalizing glycinederivatives by iron-catalysedcross-dehydrogenativecoupling (CDC) reactions. In particular, N-arylglycine derivatives reacted with alkynes by oxidative C–H/C–H couplingreactions to provide a series of substituted quinolines starting from commercially inexpensive materials. Moreover, N-arylglycine esters can be oxidatively coupled to ketones