Cyclohexanemethanol, 1-hydroxy-4-(1-methylethyl)-

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Cyclohexanemethanol, 1-hydroxy-4-(1-methylethyl)-
• 英文别名: 1-(hydroxymethyl)-4-propan-2-ylcyclohexan-1-ol
• 化学式: C₁₀H₂₀O₂
• 分子量: 172.26
• InChiKey: JRXGXNRANYXDTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20160194331A1

  公开（公告）日：2016-07-07

  The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

  本发明旨在提供一种有效生产和提供具有螺环氧吲哚骨架的化合物的方法，例如，利用不对称催化剂制备具有螺环氧吲哚骨架并具有抗肿瘤活性的化合物，该化合物抑制Mdm2蛋白与p53蛋白之间的相互作用，或其中间体。通过使用酮亚胺作为反应底物，并使用手性配体和Lewis酸进行催化不对称1,3-二极环加成反应，有效地获得具有光学活性的三环二螺吲哚骨架的化合物。
• Method for producing a spirooxindole derivative
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US10030028B2

  公开（公告）日：2018-07-24

  The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reactions using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

  本公开提供了一种利用不对称催化剂高效生产和提供具有螺氧化吲哚骨架的化合物的方法，例如具有螺氧化吲哚骨架且具有抑制Mdm2蛋白和p53蛋白之间相互作用的抗肿瘤活性的化合物或其中间体。具有光学活性的三环二螺吲哚骨架的化合物可通过催化不对称 1,3-二极环加成反应获得，该反应使用酮亚胺作为反应底物，并使用手性配体和路易斯酸。
• METHOD FOR PRODUCING A SPIROOXINDOLE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20210323970A1

  公开（公告）日：2021-10-21

  The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.