9-(3-Hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 9-(3-Hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• 英文别名: 9-(3-hydroxy-2,6,6-trimethylcyclohexen-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.4
• InChiKey: KGUMXGDKXYTTEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Stem Cell Culture Methods
  申请人：Adams David Roger

  公开号：US20120202287A1

  公开（公告）日：2012-08-09

  The invention provides methods for reversibly inhibiting stem cell differentiation wherein a compound of formula (I) is contacted with a stem cell. The invention further provides a method for preparing a culture medium, a culture medium supplement and a composition comprising a compound of formula (I).

  该发明提供了一种可逆抑制干细胞分化的方法，其中将式(I)的化合物与干细胞接触。该发明还提供了一种制备培养基、培养基添加剂和包含式(I)化合物的组合物的方法。
• Novel Polyunsaturated Compounds, Method for Preparing Same and Compositions Containing the Same
  申请人：Bordat Pascal

  公开号：US20100168045A1

  公开（公告）日：2010-07-01

  The invention concerns novel polyunsaturated compounds of formula (I) wherein: R 1 represents a R′ 1 , -A-R′ 1 group, R′ 1 being selected from —COOH, —COOR 3 , —CONH 2 , —CONHR 3 , —CONR 3 , R 4 , —CHO, —CH 2 OH, —CH 2 OR 5 , and A represents a C 2 -C 16 alkylene, alkenylene or alkynylene; R 2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC—(CH 2 )n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R′ 2 —O—R 6 group, wherein R′ 2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R 6 represents a hydrogen atom, a straight or branched optionally substituted C 1 -C 16 alkyl, a straight or branched optionally substituted C 2 -C 16 alkenyl, or a straight or branched C 2 -C 16 alkynyl group, an optionally substituted tocopheryl radical or the like, an amino acid residue, or a sugar residue. The invention also concerns the compositions, in particular cosmetic and/or dermatological compositions containing at least one compound of formula (I) as well as their use as whitening and/or depigmenting agent, and the cosmetic method using said compositions.

  本发明涉及一种新型多不饱和化合物，其化学式为(I)，其中：R1代表R′1、-A-R′1基团，R′1从-COOH、-COOR3、-CONH2、-CONHR3、-CONR3、R4、-CHO、-CH2OH、-CH2OR5中选择，A代表C2-C16烷基、烯基或炔基；R2代表：可选取取代芳基或可选取取代杂环芳基；糖残基或脂肪酸残基，可选取支链和/或取代基，优选在链末端特别是由羟基、乙酰氧基基团或可选保护的氨基基团取代的脂肪酸残基；-OC-(CH2)nCO-生育酚（α、β、γ或δ）基团，其中2≤n≤10；-R′2-O-R6基团，其中R′2为可选取取代芳烃基团或可选取取代杂环芳烃基团，R6代表氢原子、直链或支链的可选取代C1-C16烷基、直链或支链的可选取代C2-C16烯基或直链或支链的C2-C16炔基，可选取取代的生育酚基团或类似物、氨基酸残基或糖残基。本发明还涉及包含至少一种化合物(I)的组合物，特别是化妆品和/或皮肤科学组合物，以及它们作为美白和/或脱色剂的用途，以及使用所述组合物的美容方法。
• Insulin-producing cells derived from stem cells
  申请人：Hori Yuichi

  公开号：US20070154981A1

  公开（公告）日：2007-07-05

  The disclosure provides, among other things, insulin-producing cells derived from stem cells, such as human stem cells and neural stem cells. The disclosure discloses a relationship between caudalizing factors and the differentiation of insulin-producing cells.

  该披露提供了从干细胞（如人类干细胞和神经干细胞）衍生出的胰岛素产生细胞，其中包括其他内容。该披露揭示了尾端因子与胰岛素产生细胞分化之间的关系。
• SELECTIVE COMPOUNDS INHIBITING CYP26A1 USEFUL IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US20150190323A1

  公开（公告）日：2015-07-09

  Compounds or salts thereof are described that correspond to general formula (I) below: Also described, are pharmaceutical and cosmetic compositions that include these compounds. Methods of using these compounds and compositions for the treatment of pathological conditions are also described.

  本文描述了与下列一般公式（I）相对应的化合物或其盐： 同时还描述了包含这些化合物的药物和化妆品组合物。还描述了使用这些化合物和组合物治疗病理状况的方法。
• Novel C-4 substituted retinoids
  申请人：University of Maryland

  公开号：US20030162823A1

  公开（公告）日：2003-08-28

  C-4 substituted retinoic acid analogs, synthesis methods of C-4 substituted retinoic acid analogs and methods of using C-4 substituted retinoic acid analogs to treat various cancers and dermatological diseases and conditions. The C-4 substituted retinoic acid analogs include C-4 all-trans retinoic acid (ATRA) and 13-cis retinoic acid (13-CRA) analogs. The C-4 substituted retinoic acid analogs inhibit all-trans retinoic acid (ATRA) 4-hydroxylase activity, thereby inhibiting the catabolism of ATRA. The C-4 substituted retinoic acid analogs also have ATRA-mimetic activity. The preferred substitutions at C-4 are an azole group, a sulfur, oxygen, or nitrogen containing group, a pyridyl group, an ethinyl group, a cyclopropyl-amine group, an ester group, or a cyano group, or forms, together with the C-4 carbon atom, an oxime, an oxirane or aziridine group.

  C-4 取代维甲酸类似物，C-4 取代维甲酸类似物的合成方法以及使用 C-4 取代维甲酸类似物治疗各种癌症和皮肤疾病和情况的方法。C-4 取代维甲酸类似物包括 C-4 全反式视黄酸（ATRA）和 13-顺式视黄酸（13-CRA）类似物。C-4 取代维甲酸类似物抑制全反式视黄酸（ATRA）4-羟基化酶的活性，从而抑制ATRA的分解代谢。C-4 取代维甲酸类似物也具有类似ATRA的活性。C-4 最受欢迎的取代物是氮杂环，含硫、氧或氮的基团，吡啶基团，乙炔基团，环丙胺基团，酯基团或氰基团，或与 C-4 碳原子一起形成肟，环氧乙烷或氮杂环丙烷基团。