alpha-Tocopheronic acid | 1948-76-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: alpha-Tocopheronic acid
• 英文别名: 4-hydroxy-4-methyl-6-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)hexanoic acid
• CAS: 1948-76-1
• 化学式: C₁₆H₂₂O₅
• 分子量: 294.34
• InChiKey: LRYFTDGIIUTFFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] CARBOXYLIC ACID DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS<br/>[FR] DÉRIVÉS D'ACIDE CARBOXYLIQUE POUR LE TRAITEMENT DE TROUBLES DU STRESS OXYDATIF
  申请人：EDISON PHARMACEUTICALS INC

  公开号：WO2014194292A1

  公开（公告）日：2014-12-04

  Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are quinone or naphthoquinone compounds with carboxylic acid or carboxylic acid derivative substituents.

  本文公开了一种化合物及其使用方法，用于治疗或抑制氧化应激性疾病，包括线粒体疾病、能量处理障碍、神经退行性疾病和衰老疾病，或调节一个或多个能量生物标志物，规范一个或多个能量生物标志物，或增强一个或多个能量生物标志物，其中该化合物是带有羧酸或羧酸衍生物取代基的醌或萘醌化合物。
• CARBOXYLIC ACID DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS
  申请人：EDISON PHARMACEUTICALS, INC.

  公开号：US20160115141A1

  公开（公告）日：2016-04-28

  Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are quinone or naphthoquinone compounds with carboxylic acid or carboxylic acid derivative substituents.

  本文公开了化合物及其使用方法，用于治疗或抑制氧化应激性疾病，包括线粒体疾病、能量处理障碍、神经退行性疾病和衰老疾病，或调节一个或多个能量生物标志物、规范一个或多个能量生物标志物或增强一个或多个能量生物标志物，其中化合物为具有羧酸或羧酸衍生物取代基的醌或萘醌化合物。
• Process of preparing diphenylmethane derivatives
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0537954B1

  公开（公告）日：1996-07-24
• QUINONE DERIVATIVES FOR USE IN THE MODULATION OF REDOX STATUS OF INDIVIDUALS
  申请人：Edison Pharmaceuticals, Inc.

  公开号：US20150216820A1

  公开（公告）日：2015-08-06

  Methods of modulating, adjusting, and maintenance of the glutathione redox status of an individual, or cell, tissues, bodily fluids, or body compartments of the individual, are disclosed, as are compositions suitable for such modulating, adjusting, and maintenance. The modulation or adjustment is achieved by altering the amounts of reduced glutathione versus oxidized glutathione in the individual, or cells, tissues, bodily fluids, or body compartments of the individual. Modulation, adjustment, and maintenance of the redox status of an individual enables treatment, prevention or suppression of diseases or symptoms associated with diseases. These methods are achieved by using quinone derivatives.
• [EN] QUINONE DERIVATIVES FOR USE IN THE MODULATION OF REDOX STATUS OF INDIVIDUALS<br/>[FR] DÉRIVÉS QUINONE DESTINÉS À ÊTRE UTILISÉS DANS LA MODULATION DE L'ÉTAT D'OXYDORÉDUCTION CHEZ DES INDIVIDUS
  申请人：EDISON PHARMACEUTICALS INC

  公开号：WO2014039862A1

  公开（公告）日：2014-03-13

  Methods of modulating, adjusting, and maintenance of the glutathione redox status of an individual, or cell, tissues, bodily fluids, or body compartments of the individual, are disclosed, as are compositions suitable for such modulating, adjusting, and maintenance. The modulation or adjustment is achieved by altering the amounts of reduced glutathione versus oxidized glutathione in the individual, or cells, tissues, bodily fluids, or body compartments of the individual. Modulation, adjustment, and maintenance of the redox status of an individual enables treatment, prevention or suppression of diseases or symptoms associated with diseases. These methods are achieved by using quinone derivatives.