5a,5b,8,8,11a-pentamethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a-carbaldehyde

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5a,5b,8,8,11a-pentamethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a-carbaldehyde
• 化学式: C₃₀H₄₆O₂
• 分子量: 438.7
• InChiKey: MHAVMNJPXLZEIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Betulinol derivatives as anti-cancer agents
  申请人：Saxena Brij B.

  公开号：US20090176753A1

  公开（公告）日：2009-07-09

  The present invention relates to a method of treating cancer selected from the group of cancers consisting of prostate cancer, renal cancer, breast cancer, ovarian cancer, CNS cancer, melanoma, lung cancer, and bladder cancer. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a betulinol derivative compound of Formula (I). Also disclosed are conjugated and immunoconjugated derivatives of the compound of Formula (I) as well as methods of making and using them.

  本发明涉及一种治疗癌症的方法，所述癌症包括前列腺癌、肾癌、乳腺癌、卵巢癌、中枢神经系统癌症、黑色素瘤、肺癌和膀胱癌。该方法涉及向需要此类治疗的患者施用公式（I）的一种白桦醇衍生物化合物的治疗有效量。还公开了公式（I）化合物的共轭和免疫结合衍生物以及制备和使用它们的方法。
• US8088757B2
  申请人：——

  公开号：US8088757B2

  公开（公告）日：2012-01-03