4,4'-diapolycopenedial | 13920-19-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4,4'-diapolycopenedial
• 英文别名: 4,4'-diapo-β,β-carotene-4,4'-dial；2.6.10.15.19.23-Hexamethyl-tetracosaundecaen-(2.4.6.8.10.12.14.16.18.20.22)-dial；4,4'-Diapo-β,β-carotin-4,4'-dial；2,6,10,15,19,23-Hexamethyltetracosa-2,4,6,8,10,12,14,16,18,20,22-undecaenedial；2,6,10,15,19,23-hexamethyltetracosa-2,4,6,8,10,12,14,16,18,20,22-undecaenedial
• CAS: 13920-19-9
• 化学式: C₃₀H₃₆O₂
• 分子量: 428.615
• InChiKey: OBHXTIIHLYSQRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4E,6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E,28E)-2,31-二甲氧基-2,6,10,14,19,23,27,31-八甲基三十二碳-4,6,8,10,12,14,16,18,20,22,24,26,28-十三烯 在 potassium permanganate 作用下， 生成 4,4'-diapolycopenedial
  参考文献：
  名称：

  Phasic characteristic of elementary Ca²⁺release sites underlies quantal responses to IP₃

  摘要：

  Ca2+ liberation by inositol 1,4,5-trisphosphate (IP3) is 'quantal', in that low [IP3] causes only partial Ca2+ release, but further increasing [IP3] evokes more release. This characteristic allows cells to generate graded Ca2+ signals, but is unexpected, given the regenerative nature of Ca2+-induced Ca2+ release through IP3 receptors. Two models have been proposed to resolve this paradox: (i) all-or-none Ca2+ release from heterogeneous stores that empty at varying [IP3]; and (ii) phasic liberation from homogeneously sensitive stores. To discriminate between these hypotheses, we imaged subcellular Ca2+ puffs evoked by IP3 in Xenopus oocytes where release sites were functionally uncoupled using EGTA. Puffs were little changed by 300 mu M intracellular EGTA, but sites operated autonomously and did not propagate waves. Photoreleased IP3 generated flurries of puffs-different to the prolonged Ca2+ elevation following waves in control cells-and individual sites responded repeatedly to successive increments of [IP3]. These data support the second hypothesis while refuting the first, and suggest that local Ca2+ signals exhibit rapid adaptation, different to the slower inhibition following global Ca2+ waves.

  DOI：

  10.1093/emboj/19.14.3608

文献信息

• Karrer; Koenig, Helvetica Chimica Acta, 1940, vol. 23, p. 463
  作者：Karrer、Koenig

  DOI：——

  日期：——