(c)(1/2)-Tocotrienol pound>>Tocotrienol, delta

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (c)(1/2)-Tocotrienol pound>>Tocotrienol, delta
• 英文别名: 2,8-dimethyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol
• 化学式: C₂₇H₄₀O₂
• 分子量: 396.6
• InChiKey: ODADKLYLWWCHNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Treatment of mitochondrial diseases
  申请人：Walkinshaw Gail

  公开号：US20050065099A1

  公开（公告）日：2005-03-24

  The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.

  这项发明涉及治疗或改善线粒体疾病，如阿尔茨海默病、帕金森病、弗里德雷希共济失调症（FRDA）、小脑共济失调、勒伯遗传性视神经病变（LHON）、线粒体肌病、脑病、乳酸中毒、中风（MELAS）、带有红色纤维的肌阵挛性癫痫（MERFF）、肌萎缩侧索硬化症（ALS）、运动神经元疾病、亨廷顿病、黄斑变性和癫痫等疾病的治疗方法，所述方法使用本文描述的FormuLA I或FormuLA II的类胡萝卜素衍生物。
• TREATMENT OF MITOCHONDRIAL DISEASES
  申请人：Ampere Life Sciences, Inc.

  公开号：US20130267538A1

  公开（公告）日：2013-10-10

  The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.

  本发明涉及使用式I或式II所描述的色酮衍生物的治疗或改善线粒体疾病的方法，例如阿尔茨海默病、帕金森病、弗里德雷希共济失调症（FRDA）、小脑共济失调、勒伯遗传性视神经病变（LHON）、线粒体肌病、脑病、乳酸中毒、中风（MELAS）、带红纤维的肌阵挛性癫痫（MERFF）、肌萎缩侧索硬化症（ALS）、运动神经元疾病、亨廷顿病、黄斑退化和癫痫。
• POWDERS CONTAINING TOCOTRIENOLS, PROCESS FOR PRODUCING THE SAME AND TABLETS PREPARED BY COMPRESSION MOLDING THE SAME
  申请人：FUJI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1044687A1

  公开（公告）日：2000-10-18

  There are disclosed herein a powder containing tocotrienol which has an excellent storage stability and a free flowability, a process for preparing the same and a tablet which comprises compressed said powder into a tablet form. There is also disclosed a tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried.

  本文公开了一种具有极佳储存稳定性和自由流动性的含生育三烯酚的粉末、制备该粉末的工艺以及将上述粉末压缩成片剂的片剂。 还公开了一种含生育三烯酚的粉末，其制备方法是：将含有生育三烯酚的油与卵磷脂、纤维素和乳化剂在水中处理形成乳液，将粉末物质与形成的乳液混合形成悬浮液，然后将形成的悬浮液喷雾干燥。
• LOW-ALCOHOL ORAL CARE COMPOSITIONS COMPRISING ETHYL LAUROYL ARGINATE
  申请人：Lacer, S.A.

  公开号：EP3348253A1

  公开（公告）日：2018-07-18

  The present invention relates to stable aqueous low-alcohol or alcohol free oral rinse compositions comprising ethyl lauroyl arginate by use of a combination comprising at least 15 mM of gluconate anions, and Vitamin E or an ester thereof.

  本发明涉及稳定的低醇或无醇水性口腔冲洗组合物，该组合物包含月桂酰精氨酸乙酯，使用的组合物包括至少 15 毫摩尔的葡萄糖酸阴离子和维生素 E 或其酯类。
• COMPOSITIONS FOR ATOPIC SKIN
  申请人：Infinitec Activos S.L.

  公开号：EP3520774A1

  公开（公告）日：2019-08-07

  The present invention provides topical compositions comprising pinus pinaster bark extract and curcumin, particularly in microcapsules and/or nanocapsules comprising phospholipids, and to their pharmaceutical use for the prevention and/or treatment of atopic dermatitis.

  本发明提供了包含松柏树皮提取物和姜黄素的局部组合物，特别是包含磷脂的微胶囊和/或纳米胶囊，以及它们在预防和/或治疗特应性皮炎方面的药物用途。