6-hydroxy-4-methoxy-1-methyl-2-quinolone | 81943-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-hydroxy-4-methoxy-1-methyl-2-quinolone
• 英文别名: integriquinolone；2(1H)-Quinolinone, 6-hydroxy-4-methoxy-1-methyl-；6-hydroxy-4-methoxy-1-methylquinolin-2-one
• CAS: 81943-13-7
• 化学式: C₁₁H₁₁NO₃
• mdl: MFCD24392706
• 分子量: 205.213
• InChiKey: PMIJOJQWNBZWIA-UHFFFAOYSA-N

物化性质

• 熔点：
  257-260 °C
• 沸点：
  398.9±42.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-hydroxy-4-methoxy-1-methyl-2-quinolone 在 lithium aluminium tetrahydride 、 草酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 水 为溶剂， 反应 170.5h， 生成 2,3-dihydro-6-ethoxy-1-methyl-4-quinolone
  参考文献：
  名称：

  Ishii, Hisashi; Koyama, Kazuo; Chen, Ih-Sheng, Chemical and pharmaceutical bulletin, 1982, vol. 30, # 6, p. 1992 - 1997

  摘要：

  DOI：

文献信息

• FURANOCOUMARINS FOR USE IN THE TREATMENT AND/OR PREVENTION OF PARASITIC MEDIATED DISEASES
  申请人：Leeward Pacific Pte Ltd

  公开号：EP3389649B1

  公开（公告）日：2020-10-21
• COMPOUND FOR USE IN THE TREATMENT AND/OR PREVENTION OF PARASITIC MEDIATED DISEASES
  申请人：Leeward Pacific Pte Ltd

  公开号：EP3389649A1

  公开（公告）日：2018-10-24
• [EN] COMPOUND FOR USE IN THE TREATMENT AND/OR PREVENTION OF PARASITIC MEDIATED DISEASES<br/>[FR] COMPOSÉ POUR UNE UTILISATION DANS LE TRAITEMENT ET/OU LA PRÉVENTION DE MALADIES D'ORIGINE PARASITAIRE
  申请人：LEEWARD PACIFIC PTE LTD

  公开号：WO2017155465A1

  公开（公告）日：2017-09-14

  The present invention provides a compound belonging to furanocoumarin derivative having core structure (A) as given below, its pharmaceutically acceptable salt, isomer or a combination thereof for the treatment and/or prevention of a parasitic mediated disease. The present invention also provides a method for manufacturing and isolating said compound as well as method for treatment and prevention of parasitic mediated disease using said compound. In a preferred embodiment, the parasite is Plasmodium falciparum, the disease mediated by the said parasite is malaria and the furanocoumarin derivative having core structure (A) is Anisolactone.
• Ishii, Hisashi; Koyama, Kazuo; Chen, Ih-Sheng, Chemical and pharmaceutical bulletin, 1982, vol. 30, # 6, p. 1992 - 1997
  作者：Ishii, Hisashi、Koyama, Kazuo、Chen, Ih-Sheng、Lu, Sheng-Teh、Ishikawa, Tsutomu

  DOI：——

  日期：——