5,6-二羟基-8-氨基喹啉 | 17605-92-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 5,6-二羟基-8-氨基喹啉
• 英文名称: 8-amino-quinoline-5,6-diol
• 英文别名: 8-Amino-chinolin-5,6-diol；5,6-Dihydroxy-8-Aminoquinoline；8-aminoquinoline-5,6-diol
• CAS: 17605-92-4
• 化学式: C₉H₈N₂O₂
• mdl: MFCD00869693
• 分子量: 176.175
• InChiKey: VUYJUNNNRNSMEG-UHFFFAOYSA-N

物化性质

• 沸点：
  470.7±45.0 °C(Predicted)
• 密度：
  1.519±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,6-二羟基-8-氨基喹啉 在 氢氧化钾 、 air 作用下， 生成 6-hydroxy-8-imino-8H-quinolin-5-one
  参考文献：
  名称：

  Quinolinequinones.¹ I. Quinones and Hydroquinones Related to Pentaquine^1a

  摘要：

  DOI：

  10.1021/ja01146a011
• 作为产物：
  描述：

  8-amino-5,6-dimethoxyquinoline 在 氢溴酸 作用下， 生成 5,6-二羟基-8-氨基喹啉
  参考文献：
  名称：

  Quinolinequinones.¹ I. Quinones and Hydroquinones Related to Pentaquine^1a

  摘要：

  DOI：

  10.1021/ja01146a011

文献信息

• METHOD FOR THE TREATMENT OF MALARIA BY THE USE OF PRIMAQUINE DERIVATIVE N1-(3-ETHYLIDINOTETRAHYDROFURAN-2-ONE) -N 4-(6-METHOXY-8-QUINOLINYL)-1,4-PENTANEDIAMINE AS GAMETOCYTOCIDAL AGENT
  申请人：——

  公开号：US20030199697A1

  公开（公告）日：2003-10-23

  The present invention a novel use of primaquine derivative N 1 -(3-ethylidinotetrahydrofuran-2-one)-N 4 -(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and contolling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N 1 -(3-ethylidinotetrahydrofuran-2-one)-N 4 -(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

  本发明涉及一种新的利用盐酸伯氨喹衍生物N1-（3-乙烯基四氢呋喃-2-酮）-N4-（6-甲氧基-8-喹啉基）-1,4-戊二胺治疗和控制疟疾传播的方法。特别是，本发明揭示了一种利用盐酸伯氨喹衍生物N1-（3-乙烯基四氢呋喃-2-酮）-N4-（6-甲氧基-8-喹啉基）-1,4-戊二胺作为配子体杀虫剂治疗疟疾的方法。
• Use of primaquine derivatives for the treatment of malaria
  申请人：Council of Scientific and Industrial Research

  公开号：EP1055427B1

  公开（公告）日：2004-10-13
• DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR
  申请人：Lagrange Alain

  公开号：US20140041133A1

  公开（公告）日：2014-02-13

  The present invention relates to a cosmetic composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising: a) one or more fatty substances; b) one or more surfactants; c) one or more oxidation bases; d) one or more couplers based on 2-hydroxynaphthalene derivatives or particular phenol derivatives, acylaminophenol derivatives or quinoline derivatives; f) one or more basifying agents; e) optionally one or more chemical oxidizing agents; and the fatty substance content representing in total at least 25% by weight relative to the total weight of the formulation. The present invention also relates to a process using this composition, and to a multi-compartment device that is suitable for performing the said process.
• US7183291B2
  申请人：——

  公开号：US7183291B2

  公开（公告）日：2007-02-27
• US9028562B2
  申请人：——

  公开号：US9028562B2

  公开（公告）日：2015-05-12