[10-(2-Hydroxyacetyl)oxy-1,5-dimethyl-8-propan-2-yl-11-oxatricyclo[6.2.1.02,6]undecan-7-yl] 2-chloro-3-ethoxy-3-phenylpropanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [10-(2-Hydroxyacetyl)oxy-1,5-dimethyl-8-propan-2-yl-11-oxatricyclo[6.2.1.02,6]undecan-7-yl] 2-chloro-3-ethoxy-3-phenylpropanoate
• 化学式: C₂₈H₃₉ClO₇
• 分子量: 523.1
• InChiKey: UGAYVSQAGFEVTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• METHODS OF TREATING OR PREVENTING INSULIN RESISTANCE AND ASSOCIATED DISEASES AND CONDITIONS
  申请人：The United States of America,as represented by the Secretary, Department of Health and Human Service

  公开号：US20140350093A1

  公开（公告）日：2014-11-27

  Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R 1 -R 6 are described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality.
• METHODS OF TREATING PATIENTS INFECTED WITH HIV AND HTLV
  申请人：THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE

  公开号：US20150283111A1

  公开（公告）日：2015-10-08

  Disclosed is a method of activating protein kinase C theta (PKCθ) in an HIV or HTLV infected animal comprising administering to the animal an effective amount of a compound of formula (I): Formula (I), or an epimer thereof; wherein Ar and R 1 -R 6 are described herein. Examples of diseases or conditions associated with PKCθ include HIV1 infection, AIDS, HTLV infection, and adult T cell leukemia/lymphoma.
• US8410292B2
  申请人：——

  公开号：US8410292B2

  公开（公告）日：2013-04-02
• US9101601B2
  申请人：——

  公开号：US9101601B2

  公开（公告）日：2015-08-11
• US9517224B2
  申请人：——

  公开号：US9517224B2

  公开（公告）日：2016-12-13