3,7-Dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,7-Dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide
• 英文别名: N-(3,7-dimethylocta-2,6-dienyl)cyclopropanecarboxamide
• 化学式: C₁₄H₂₃NO
• 分子量: 221.34
• InChiKey: UKNMSFRSBQONET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• [EN] OXALAMIDE DERIVATIVE AS UMAMI FLAVOURING AGENT<br/>[FR] DÉRIVÉ D'OXALAMIDE À TITRE D'AGENT DE SAVEUR UMAMI
  申请人：GIVAUDAN SA

  公开号：WO2011095533A1

  公开（公告）日：2011-08-11

  The compound of the formula (1) is novel and is useful in conferring umami taste on consumable compositions, such as foodstuffs and beverages.

  这种化学式（1）的化合物是新颖的，可用于赋予食品和饮料等可食用成分鲜味。
• Oxalamide Derivative As Umami Flavouring Agent
  申请人：Kaouas Abdelmajid

  公开号：US20120301587A1

  公开（公告）日：2012-11-29

  The compound of the formula (1) is novel and is useful in conferring umami taste on consumable compositions, such as foodstuffs and beverages.

  公式（1）的化合物是新颖的，并且在赋予食品和饮料等可食用组合物鲜味方面非常有用。
• Pyridine Derivatives With Umami Flavour
  申请人：Wang Yili

  公开号：US20120121783A1

  公开（公告）日：2012-05-17

  A compound (including salts thereof) according to Formula I in which R 1 is H, methyl or ethyl; R 2 is H, OH, fluorine, C 1 -C 4 linear or branched alkyl, C 1 -C 6 alkoxy wherein the alkyl group is linear or branched, or a C 3 -C 5 cycloalkyl moiety; R 3 is H, methoxy, methyl or ethyl; or R 2 and R 3 together form a bridging moiety —O—CH 2 —O— between the phenyl carbon atoms to which they are connected; R 4 is OH or methoxy; and R 5 and R 6 are independently H or methyl; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are such that, (i) when R 2 and R 3 together form a bridging moiety —O—CH 2 —O— between the phenyl carbon atoms to which they are connected, R 1 , R 5 , R 6 are H, and R 4 is OH; and (ii) when R 4 is OH and R 1 —R 3 are H, at least one of R 5 , R 6 is methyl.

  公式I中的化合物（包括其盐），其中R1为H，甲基或乙基；R2为H，OH，氟，C1-C4线性或支链烷基，C1-C6烷氧基，其中烷基是线性或支链的，或C3-C5环烷基；R3为H，甲氧基，甲基或乙基；或R2和R3一起形成桥接基-O-CH2-O-，位于它们连接的苯基碳原子之间；R4为OH或甲氧基；且R5和R6独立地为H或甲基；R1，R2，R3，R4，R5和R6的取值使得，（i）当R2和R3一起形成桥接基-O- -O-，位于它们连接的苯基碳原子之间时，R1，R5，R6为H，R4为OH；（ii）当R4为OH且R1-R3为H时，至少有一个R5，R6为甲基。