glycocitridine | 167504-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: glycocitridine
• 英文别名: 4,7,8-trimethoxy-2-oxo-1H-quinoline-3-carbaldehyde
• CAS: 167504-57-6
• 化学式: C₁₃H₁₃NO₅
• 分子量: 263.25
• InChiKey: VWYALKKHDZGUAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,4-二甲氧基苯乙胺 、 glycocitridine 以 苯 为溶剂， 反应 4.0h， 以85.6%的产率得到3-formyl-4-(3,4-dimethoxyphenylethylamino)-7,8-dimethoxyquinolin-2-one
  参考文献：
  名称：

  Ipso-Substitution in Derivatives of the Quinoline Alkaloid Skimmianine

  摘要：

  生物碱 skimmianine 氧化产生了甲酰基衍生物，该衍生物与高藜芦碱反应生成了亲核同素异形反应产物 3-甲酰基-4-（3,4-二甲氧基苯乙基氨基）-7,8-二甲氧基喹啉-2-酮。后者中甲酰基团的存在促使其在酸性溶液中进一步在 H 原子上发生同素异形反应，生成 4-(3,4-二甲氧基苯乙基氨基)-7,8-二甲氧基喹啉-2-酮，其结构已通过 X 射线晶体结构分析得到证实。

  DOI：

  10.1007/s10600-021-03398-8
• 作为产物：
  描述：

  2,3-二甲氧基苯胺 在 吡啶 、 盐酸 、 正丁基锂 、 四甲基乙二胺 、 三氯氧磷 作用下， 以 甲醇 、 氯苯 为溶剂， 反应 46.5h， 生成 glycocitridine
  参考文献：
  名称：

  Tagawa, Yoshinobu; Kawaoka, Takamitsu; Goto, Yoshinobu, Journal of Heterocyclic Chemistry, 1997, vol. 34, # 6, p. 1677 - 1683

  摘要：

  DOI：

文献信息

• Mookerjee; Bose, Journal of the Indian Chemical Society, 1946, vol. 23, p. 1,5
  作者：Mookerjee、Bose

  DOI：——

  日期：——
• Self-consistent elastoplastic stress solutions for functionally graded material systems subjected to thermal transients
  作者：S. Pitakthapanaphong、E.P. Busso

  DOI：10.1016/s0022-5096(01)00105-3

  日期：2002.4

  In this work, a self-consistent constitutive framework is proposed to describe the behaviour of a generic three-layered system containing a functionally graded material (FGM) layer subjected to thermal loading. Analytical and semi-analytical solutions are obtained to describe the thermo-elastic and thermo-elastoplastic behaviour of a three-layered system consisting of a metallic and a ceramic layer joined together by an FGM layer of arbitrary composition profile. Solutions for the stress distributions in a generic FGM system subjected to arbitrary temperature transient conditions are presented. The homogenisation of the local elastoplastic FGM behaviour in terms of the properties of its individual phases is performed using a self-consistent approach. In this work, power-law strain hardening behaviour is assumed for the FGM metallic phase. The stress distributions within the FGM systems are compared with accurate numerical solutions obtained from finite element analyses and good agreement is found throughout. Solutions are also given for the critical temperature transients required for the onset of plastic deformation within the three-layered systems. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Ipso-Substitution in Derivatives of the Quinoline Alkaloid Skimmianine
  作者：M. A. Eshonov、V. I. Vinogradova、Kh. A. Rasulova、K. K. Turgunov、B. Tashkhodzhaev

  DOI：10.1007/s10600-021-03398-8

  日期：2021.5

  Oxidation of the alkaloid skimmianine produced a formyl derivative that reacted with homoveratrylamine to give the product of nucleophilic ipso-substitution 3-formyl-4-(3,4-dimethoxyphenylethylamino)-7,8- dimethoxyquinolin-2-one. The presence of the formyl group in the latter stimulated its further ipso-substitution at the H atom in acidic solution to form 4-(3,4-dimethoxyphenylethylamino)-7,8-dimethoxyquinolin-2-one, the structure of which was confirmed by an X-ray crystal structure analysis.

  生物碱 skimmianine 氧化产生了甲酰基衍生物，该衍生物与高藜芦碱反应生成了亲核同素异形反应产物 3-甲酰基-4-（3,4-二甲氧基苯乙基氨基）-7,8-二甲氧基喹啉-2-酮。后者中甲酰基团的存在促使其在酸性溶液中进一步在 H 原子上发生同素异形反应，生成 4-(3,4-二甲氧基苯乙基氨基)-7,8-二甲氧基喹啉-2-酮，其结构已通过 X 射线晶体结构分析得到证实。
• Tagawa, Yoshinobu; Kawaoka, Takamitsu; Goto, Yoshinobu, Journal of Heterocyclic Chemistry, 1997, vol. 34, # 6, p. 1677 - 1683
  作者：Tagawa, Yoshinobu、Kawaoka, Takamitsu、Goto, Yoshinobu

  DOI：——

  日期：——