11-oxo-acetyl ursolic acid | 35959-01-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 11-oxo-acetyl ursolic acid
• 英文别名: 3β-Acetoxy-11-oxo-3-ursolsaeure；11-oxoursolic acid acetate；(1S,2R,4aS,6aS,6bR,10S,12aS)-10-acetyloxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,5,6,6a,7,8,8a,10,11,12,14b-tetradecahydropicene-4a-carboxylic acid
• CAS: 35959-01-4；71623-71-7
• 化学式: C₃₂H₄₈O₅
• 分子量: 512.73
• InChiKey: XDHCWTUZCOFKRH-IKXLYDHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA
  申请人：Orphagen Pharmaceuticals

  公开号：US20130150333A1

  公开（公告）日：2013-06-13

  Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor γ (RORγ) activity. This modulation has numerous effects, including inhibition of T H -17 cell function and/or T H -17 cell activity, and inhibition of re-stimulation of T H -17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of RORγ results in stimulation of T H -17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).

  调节（抑制或刺激）视黄醇相关孤儿受体γ（RORγ）活性的方法。这种调节具有许多效果，包括抑制TH-17细胞功能和/或TH-17细胞活性，以及抑制TH-17细胞再激活，这对治疗炎症和自身免疫性疾病有益。刺激RORγ会导致TH-17细胞功能和/或活性的刺激，这对于免疫增强组合物（例如疫苗）有益。
• Ursolic acid for inhibiting muscle atrophy
  申请人：University of Iowa Research Foundation

  公开号：EP2571354B1

  公开（公告）日：2020-07-08
• METHODS FOR INHIBITING MUSCLE ATROPHY
  申请人：Adams Christopher M.

  公开号：US20130203712A1

  公开（公告）日：2013-08-08

  In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• COMPOSITIONS AND METHODS FOR INHIBITING MUSCLE ATROPHY AND INDUCING MUSCLE HYPERTROPHY
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US20140371188A1

  公开（公告）日：2014-12-18

  In an aspect, the invention relates to compositions, methods, and kits for inhibiting or preventing skeletal muscle atrophy or inducing muscle hypertrophy by providing to an animal an effective amount of a composition comprising a Gadd45a and/or Cdkn1a inhibitor and an androgen and/or growth hormone elevator or an androgen and/or growth hormone receptor activator. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US8389739B1
  申请人：——

  公开号：US8389739B1

  公开（公告）日：2013-03-05