Retinoic acid, 2-hydroxy- | 126892-65-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Retinoic acid, 2-hydroxy-
• 英文别名: (2E,4E,6E,8E)-9-(5-hydroxy-2,6,6-trimethylcyclohexen-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• CAS: 126892-65-7
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.4
• InChiKey: NZLMCEZCDGPVLK-BJFGXJFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Method for producing N-retinoylcysteic acid alkyl ester
  申请人：ARDENIA INVESTMENTS, LTD.

  公开号：US10138204B2

  公开（公告）日：2018-11-27

  A method for producing derivatives of N-retinoylaminoalkane sulfonic acid, the method comprising providing retinoic acid, chloroformate, aminoalkanesulfonic acid selected from the group consisting of cysteic acid and alkyl ester thereof, cysteinesulfinic acid and alkyl ester thereof, homocysteic acid and alkyl ester thereof, homocysteinesulfinic acid and alkyl esters thereof, taurine and derivatives thereof, and an organic solvent, and a base, mixing said components under substantial absence of oxidizing compounds thereby forming a reaction mixture comprising a liquid phase, wherein the liquid phase is one phase and the derivatives of N-retinoylaminoalkane sulfonic acid are formed in said liquid phase.

  一种生产N-视黄基氨基烷磺酸衍生物的方法，该方法包括提供视黄酸、氯甲酸、选自半胱氨酸及其烷基酯、半胱氨酸亚磺酸及其烷基酯、高半胱氨酸及其烷基酯、高半胱氨酸亚磺酸及其烷基酯组成的氨基烷磺酸、牛磺酸及其衍生物、有机溶剂和碱，在基本上没有氧化性化合物的条件下混合所述组分，从而形成包含液相的反应混合物，其中液相为单相，N-retinoylaminoalkane 磺酸的衍生物在所述液相中形成。
• Use of Polyunsaturated Compounds as Whitening Agents
  申请人：Bordat Pascal

  公开号：US20090304614A1

  公开（公告）日：2009-12-10

  The invention concerns the cosmetic or dermatological use of at least one compound of formula (I), wherein: R 1 , R 2 , R 3 , R 4 , R 5 and G are such as defined in the description as whitening and/or depigmenting agents for the skin and/or hairs and/or the hair. The invention also concerns a cosmetic method for whitening and/or lightening the skin and/or hairs and/or the hair comprising applying a composition of the invention.
• METHOD FOR PRODUCING N-RETINOYLCYSTEIC ACID ALKYL ESTER
  申请人：ARDENIA INVESTMENTS, LTD.

  公开号：US20180290973A1

  公开（公告）日：2018-10-11

  A method for producing derivatives of N-retinoylaminoalkane sulfonic acid, the method comprising providing retinoic acid, chloroformate, aminoalkanesulfonic acid selected from the group consisting of cysteic acid and alkyl ester thereof, cysteinesulfinic acid and alkyl ester thereof, homocysteic acid and alkyl ester thereof, homocysteinesulfinic acid and alkyl esters thereof, taurine and derivatives thereof, and an organic solvent, and a base, mixing said components under substantial absence of oxidizing compounds thereby forming a reaction mixture comprising a liquid phase, wherein the liquid phase is one phase and the derivatives of N-retinoylaminoalkane sulfonic acid are formed in said liquid phase.
• METABOLIC PROFILING WITH MAGNETIC RESONANCE MASS SPECTROMETRY (MRMS)
  申请人：Oregon Institute of Science and Medicine

  公开号：US20190391092A1

  公开（公告）日：2019-12-26

  A method for constructing a metabolic profile of a mammalian (such as a human) subject from one of more urine samples from the subject uses magnetic resonance mass spectrometry (MRMS) for the rapid and inexpensive quantitative measurement of at least 4,000 urinary chemical substances in a single analysis. The method for metabolic profiling measures thousands of urinary substances in a urine sample from a mammalian subject in a single assay. Many of these substances can be of mammalian metabolic origin. The measurements of types and amounts of urinary substances can be correlated to assessments of present or future health of the subject.
• US4194007A
  申请人：——

  公开号：US4194007A

  公开（公告）日：1980-03-18