3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one
• 英文别名: 3a-Hydroxy-5a,9-dimethyl-3-methylidene-4,5,6,7,8,9b-hexahydrobenzo[g][1]benzofuran-2-one
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: XMPDAVDYIOMTLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] 7-HYDROXYFRULLANOLIDE AND ITS ANALOGS FOR PREVENTION, CONTROL AND TREATMENT OF METABOLIC DISORDERS<br/>[FR] 7-HYDROXYFRULLANOLIDE ET SES ANALOGUES POUR LA PRÉVENTION, LA MAÎTRISE ET LE TRAITEMENT DE TROUBLES DU MÉTABOLISME.
  申请人：LAILA NUTRACEUTICALS

  公开号：WO2012014216A1

  公开（公告）日：2012-02-02

  The invention discloses biologically active ingredient(s) selected from 7- hydroxyfrullanolide, its analogs, the extract(s) and fraction(s) standardized to 7- hydroxyfrullanolide or its analogs or both or mixtures thereof or their composition(s) for the prevention, control and treatment of one or more obesity, overweight, metabolic syndrome, diabetes and other metabolic disorders or for producing lean body mass in a warm blooded animal in need thereof.

  本发明揭示了从7- 羟基富尔醛内酯、其类似物、提取物和分离物中选择的生物活性成分，这些成分经标准化处理得到7- 羟基富尔醛内酯或其类似物或两者或二者的混合物，或它们的组合物，用于预防、控制和治疗一种或多种肥胖、超重、代谢综合征、糖尿病和其他代谢紊乱，或用于在需要的温血动物中产生瘦体重。
• COMPOSITION FROM SPHAERANTHUS INDICUS AND GARCINIA MANGOSTANA FOR THE CONTROL OF METABOLIC SYNDROME
  申请人：GOKARAJU Ganga Raju

  公开号：US20160074457A1

  公开（公告）日：2016-03-17

  Pharmaceutical/dietary supplements and food ingredient(s) derived from Sphaeranthus indicus are used for controlling or treating a metabolic disorder. The supplements and food ingredient(s) are selected from Sphaeranthus indicus extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana . The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

  来自Sphaeranthus indicus的药物/膳食补充剂和食品成分用于控制或治疗代谢性疾病。这些补充剂和食品成分从Sphaeranthus indicus提取物、分离物、活性化合物和植物化学物或其混合物及其组合物中选择，优选与从Garcinia mangostana中提取的提取物、分离物、活性化合物和植物化学物或其混合物中的至少一种成分结合。这些成分和组合物可用于控制、预防和治疗肥胖症、代谢综合征、糖尿病和其他代谢性疾病，以及调节能量消耗，预防冠状动脉和腹主动脉的动脉粥样硬化斑块，提高胰岛素敏感性，改善葡萄糖耐量，降低三酰甘油水平并平衡哺乳动物的葡萄糖水平。
• Composition from Sphaeranthus indicus and Garcinia mangostana for the control of metabolic syndrome
  申请人：LAILA NUTRACEUTICALS

  公开号：US10471114B2

  公开（公告）日：2019-11-12

  Pharmaceutical/dietary supplements and food ingredient(s) derived from Sphaeranthus indicus are used for controlling or treating a metabolic disorder. The supplements and food ingredient(s) are selected from Sphaeranthus indicus extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

  萃取自 Sphaeranthus indicus 的药物/膳食补充剂和食品配料用于控制或治疗代谢紊乱。补充剂和食品成分选自 Sphaeranthus indicus 提取物、馏分、活性化合物和植物化学物质或其混合物及其组合物，最好与至少一种选自芒果提取物、馏分、活性化合物和植物化学物质或其混合物的成分结合使用。这些成分和组合物可用于控制、预防和治疗肥胖、代谢综合征、糖尿病和其他代谢紊乱，还可用于调节能量消耗、预防冠状动脉和腹主动脉粥样硬化斑块、增加胰岛素敏感性、改善葡萄糖耐量、降低甘油三酯水平和平衡哺乳动物体内的葡萄糖水平。
• HERBAL COMPOSITION FOR INFLAMMATORY DISORDERS
  申请人：Nicholas Piramal India Limited

  公开号：EP1931366A2

  公开（公告）日：2008-06-18
• 炎症性疾患のための薬草組成物
  申请人：ピラマル・ライフ・サイエンシーズ・リミテッド

  公开号：JP5331962B2

  公开（公告）日：2009-03-12