9,13-epoxy-labd-7-en-15-oic acid | 1438-57-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 9,13-epoxy-labd-7-en-15-oic acid
• 英文别名: Grindelsaeure；Spiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetic acid, 4,4'a,5,5',6',7',8',8'a-octahydro-2',5,5',5',8'a-pentamethyl-, [1'R-[1'alpha(S*),4'aalpha,8'abeta]]-；2-(2',4,4,7,8a-pentamethylspiro[2,3,4a,5-tetrahydro-1H-naphthalene-8,5'-oxolane]-2'-yl)acetic acid
• CAS: 1438-57-9；98103-38-9
• 化学式: C₂₀H₃₂O₃
• 分子量: 320.472
• InChiKey: XLWWERNKTLITEF-UHFFFAOYSA-N

物化性质

• 熔点：
  100-101°
• 比旋光度：
  D -102.2°
• 沸点：
  434.7±28.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)
• LogP：
  5.650 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• WGK Germany：
  3

文献信息

• Grindelia extracts depleted in grindelic acid and uses thereof
  申请人：Aboca S.p.A. Societa' Agricola

  公开号：EP2857067A1

  公开（公告）日：2015-04-08

  The present invention relates to new fractions of grindelia extracts in which only traces of grindelic acid, saponins and resins are present, a process for the preparation of such fractions, compositions comprising them, and use thereof for the protection or for cooperating with the protection of skin or mucous membranes.

  本发明涉及研磨草提取物中仅含有微量研磨草酸、皂苷和树脂的新馏分、制备此类馏分的工艺、包含此类馏分的组合物，以及将其用于保护或配合保护皮肤或粘膜的用途。
• Increasing productivity of E. coli host cells that functionally express P450 enzymes
  申请人：Manus Bio, Inc.

  公开号：US10774314B2

  公开（公告）日：2020-09-15

  The present invention relates to the production of chemical species in bacterial host cells. Particularly, the present invention provides for the production of chemical species in Escherichia coli (E. coli) host cells that functionally express engineered P450 enzymes.

  本发明涉及在细菌宿主细胞中生产化学物质。特别是，本发明提供了在大肠杆菌（E. coli）宿主细胞中生产化学物质的方法，这些宿主细胞在功能上表达工程化的 P450 酶。
• INCREASING PRODUCTIVITY OF E. COLI HOST CELLS THAT FUNCTIONALLY EXPRESS P450 ENZYMES
  申请人：Manus Biosynthesis, Inc.

  公开号：EP3337893A1

  公开（公告）日：2018-06-27
• METHODS AND COMPOSITIONS FOR REDUCING RISK OF RELAPSE AND PROLONGING SURVIVAL IN ACUTE MYELOID LEUKEMIA
  申请人：Martner, Anna

  公开号：EP3796911A2

  公开（公告）日：2021-03-31
• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.