2-(2,6-Diaminohexanoylamino)-3-methylbutanoic acid | 20556-11-0

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2,6-Diaminohexanoylamino)-3-methylbutanoic acid
• CAS: 20556-11-0
• 化学式: C₁₁H₂₃N₃O₃
• 分子量: 245.32
• InChiKey: YQAIUOWPSUOINN-UHFFFAOYSA-N

物化性质

• 沸点：
  496.8±45.0 °C(Predicted)
• 密度：
  1.119±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2924199090

文献信息

• AMINO ACID-, PEPTIDE- AN POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AN USES THEREOF
  申请人：Massachusetts Institute Of Technology

  公开号：EP4074694A1

  公开（公告）日：2022-10-19

  Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as "APPLs". Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R', R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

  本文描述的化合物和组合物，在某些实施方案中，通过将各种基团（如亲油基团）与氨基酸的氨基或酰胺基团、线性或环状肽、线性或环状多肽或其结构异构体共轭，以提供本发明的化合物，本文统称为 "APPLs"。此类 APPL 被认为可用于多种应用，例如，改善核苷酸递送。示例性 APPL 包括但不限于本文所述的式 (I)、(II)、(III)、(IV)、(V) 和 (VI) 及其盐类化合物： 其中 m、n、p、R'、R1、R2、R3、R4、R5、R8、Z、W、Y 和 Z 如本文所定义。
• Amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10682374B2

  公开（公告）日：2020-06-16

  Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

  本文描述的化合物和组合物，在某些实施方案中，通过将各种基团（如亲油基团）与氨基酸的氨基或酰胺基团、线性或环状肽、线性或环状多肽或其结构异构体共轭，以提供本发明的化合物，本文统称为 "APPLs"。此类 APPL 被认为可用于多种应用，例如，改善核苷酸递送。示例性 APPL 包括但不限于本文所述的式 (I)、(II)、(III)、(IV)、(V) 和 (VI) 及其盐类化合物： 其中 m、n、p、R′、R1、R2、R3、R4、R5、R8、Z、W、Y 和 Z 如本文所定义。
• Compositions and methods for improving skin health and for the treatment and prevention of diseases, disorders and conditions associated with pathogenic microbes
  申请人：DermBiont, Inc.

  公开号：US11040077B2

  公开（公告）日：2021-06-22

  Disclosed herein are compositions and methods for using human-derived Janthinobacterium lividum. Compositions improve skin health. Methods may include applying human-derived Janthinobacterium lividum over a host or host area, such as skin or mucosa, to minimize the presence of one or more microbes, maximize therapeutic effects, and/or improve health. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-derived Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic to maximize growth and/or metabolites. Compositions and methods may include human-derived Janthinobacterium lividum metabolites, such as violacein, prodigiosin, indole-3-carboxaldehyde, and lantibiotics, and/or other Postbiotics.

  本文公开了使用源自人类的 Lividum Janthinobacterium 的组合物和方法。组合物可改善皮肤健康。方法可包括在宿主或宿主区域（如皮肤或粘膜）上施用源于人的生发的Lividum Janthinobacterium，以最大限度地减少一种或多种微生物的存在，最大限度地提高治疗效果，和/或改善健康状况。减少病原微生物的方法可包括向表面施用一种组合物，该组合物包括来源于人类的Janthinobacterium lividum和一种可接受的载体。组合物和方法可包括益生元，以最大限度地提高生长和/或代谢物。组合物和方法可包括来源于人的猪蓝细菌代谢物，如violacein、prodigiosin、吲哚-3-甲醛、兰特益生菌和/或其他后益生菌。
• AMINO ACID-, PEPTIDE-AND POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20130158021A1

  公开（公告）日：2013-06-20

  Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , Z, W, Y, and Z are as defined herein.
• AMINO ACID-, PEPTIDE- AND POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20170165290A1

  公开（公告）日：2017-06-15

  Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , Z, W, Y, and Z are as defined herein.