4-methylaminopent-3-en-2-one | 130256-90-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methylaminopent-3-en-2-one
• 英文别名: 4-(Methylamino)pent-3-en-2-one；(E)-4-(methylamino)pent-3-en-2-one
• CAS: 130256-90-5
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: FNMKFVXIVPDFBL-SNAWJCMRSA-N

物化性质

• 沸点：
  195.0±23.0 °C(Predicted)
• 密度：
  0.891±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methylaminopent-3-en-2-one 以 乙醇 、 氯仿 为溶剂， 生成 [Co(CH3C(O)CHC(CH3)NCH3)2(bipy)]*H2O
  参考文献：
  名称：

  Synthesis and Physicochemical Properties of Some β‐Ketoaminato Cobalt(II) Chelates and Their Adducts with 2,2′‐Bipyridine and 1,10‐Phenanthroline

  摘要：

  The cobalt(II) beta-ketoamines complexes {Co[CH3C(O)CHC(CH3)NR](2); R = CH3, CH2(OH)CH2, C4H9} and ketoiminates {Co[CH3C(O)CH(CH3) C(-N(CH2)(n)N-)C(CH3)CHC(O)CH3]} and their adducts with 2,2'-bipyridine (bipy) and 1,10-phenanthroline (phen) have been synthesized and characterized by elemental analyses, magnetic susceptibility, conductivity, infrared, and electronic spectral measurements. The ligands coordinate to the cobalt ion in a bidentate manner using the N2O2 chromophore. The effective magnetic moments (mu(eff)) observed for the complexes are in the range of 4.20-5.30 BM. Electronic spectra results and magnetic susceptibility measurements are consistent with the adoption of a four-coordinate geometry for the cobalt(II) chelates and a six-coordinate octahedral geometry for the 2,2'-bipyridine and 1,10-phenanthroline adducts. The available conductance data in nitromethane indicates that the compounds are non-electrolytes.

  DOI：

  10.1081/sim-200026294
• 作为产物：
  描述：

  4,5-Diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborol 、 乙酰丙酮 以 正戊烷 为溶剂， 以92%的产率得到1-(2-甲基-1,3-苯并噁唑-6-基)-3-(1,5-二氮杂萘-4-基)脲
  参考文献：
  名称：

  Koester, Roland; Seidel, Guenter; Boese, Roland, Chemische Berichte, 1988, vol. 121, p. 597 - 616

  摘要：

  DOI：

文献信息

• COBALT COMPLEX, METHOD FOR MANUFACTURING SAME, AND METHOD FOR MANUFACTURING COBALT-CONTAINING THIN FILM
  申请人：TOSOH CORPORATION

  公开号：US20220017553A1

  公开（公告）日：2022-01-20

  To provide a cobalt complex which is liquid at room temperature, useful for producing a cobalt-containing thin film under conditions without using an oxidizing gas. A cobalt complex represented by the following formula (1): L 1 -Co-L 2 (1) wherein L 1 and L 2 represent a unidentate amide ligand of the following formula (A), a bidentate amide ligand of the following formula (B) or a hetero atom-containing ligand of the following formula (C): wherein R 1 and R 2 represent a C 1-6 alkyl group or a tri(C 1-6 alkyl)silyl group, and the wave line represents a binding site to the cobalt atom; wherein R 3 represents a tri(C 1-6 alkyl)silyl group, R 4 and R 5 represent a C 1-4 alkyl group, and X represents a C 1-6 alkylene group; wherein R 6 and R 8 represent a C 1-6 alkyl group, R 7 represents a hydrogen atom or a C 1-4 alkyl group, Y represents an oxygen atom or NR 9 , Z represents an oxygen atom or NR 10 , and R 9 and R 10 independently represent a C 1-6 alkyl group.

  提供一种在室温下为液体的钴配合物，可用于在不使用氧化气体的条件下制备含钴薄膜。 由以下式（1）表示的钴配合物： L1-Co-L2（1） 其中L1和L2表示以下式（A）的单齿酰胺配体，以下式（B）的双齿酰胺配体或以下式（C）的含杂原子配体： 其中R1和R2表示C1-6烷基或三(C1-6烷基)硅基团，波浪线表示与钴原子的结合位点； 其中R3表示三(C1-6烷基)硅基团，R4和R5表示C1-4烷基，X表示C1-6亚烷基团； 其中R6和R8表示C1-6烷基，R7表示氢原子或C1-4烷基，Y表示氧原子或NR9，Z表示氧原子或NR10，R9和R10独立表示C1-6烷基。
• 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-Mediated C(<i>sp</i> ² )-C(<i>sp</i> ³ ) Cross-Dehydrogenative Coupling Reaction: α-Alkylation of Push-Pull Enamines and α-Oxo Ketene Dithioacetals
  作者：Dongping Cheng、Lijun Wu、Zhiteng Deng、Xiaoliang Xu、Jizhong Yan

  DOI：10.1002/adsc.201700853

  日期：2017.12.19

  A novel, metal‐free cross‐dehydrogenative coupling (CDC) reaction of C(sp2)–H bonds of enamines and α‐oxo ketene dithioacetals with C(sp3)–H bonds of 1,3‐diarylpropenes mediated by 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) is reported. The α‐alkylation products are obtained with moderate to good yields. The method provides an efficient and alternative strategy for the synthesis of the corresponding

  一种新型的，无金属的交叉脱氢偶联（CDC）C的反应（SP 2）烯胺与α氧代烯酮二硫的-H键与C（SP 3）1,3- diarylpropenes -H键由2介导的，报告了3-二氯-5,6-二氰基-1,4-苯醌（DDQ）。获得的α-烷基化产物的产率中等至良好。该方法提供了用于合成相应产物的有效且可替代的策略。
• 1,4,9,10-Anthradiquinone as precursor for antitumor compounds
  作者：Lothar Werner Schenck、Krystina Kuna、Walter Frank、Antje Albert、Christian Asche、Uwe Kucklaender

  DOI：10.1016/j.bmc.2006.01.026

  日期：2006.5

  5-hydroxyindoles were not obtained from this diquinone. It yielded similar reaction products of the Nenitzescu reaction like other quinones activated by two electron-withdrawing groups. Furthermore, these new compounds 8A were found to constitute precursors for the synthesis of azonines. The conversion to dibenzoazonines 13 occurred in an unusual and up to now unknown way consisting of isomerization, ring opening

  在Nenitzescu反应中，将1,4,9,10-蒽醌5与烯胺6反应生成意外的3,3a，6,12-四氢-3a，7-二羟基-2-甲基-6,12-二氧代萘[ 2,3-d]吲哚-1-汽车的羧酸酯化了8A。但是，从该二醌未获得蒽环类的萘缩合的5-羟基吲哚。它产生了Nenitzescu反应的类似反应产物，就像被两个吸电子基团激活的其他醌一样。此外，发现这些新的化合物8A构成合成腺嘌呤的前体。转化为二苯并azonines 13的方式非常罕见，直到现在还不为人所知，包括异构化，开环和重新闭合。2-氯蒽醌19与烯胺6以乙烯基葡糖酰氯反应生成吡咯并蒽醌20。未观察到氯的取代。萘酚缩合的吲哚26是通过未取代的1，4-蒽醌25与烯胺6通过常规的Nenitzescu路线反应而获得的。吲哚26被转化为曼尼希碱，通过中间体邻醌甲基化物的狄尔斯-阿尔德反应进一步与二聚体反应。在NCI面向人类疾病的体外抗癌筛选中，对大多
• Rare earth chelates of α,β-unsaturated-β-ketoamines
  作者：A.K. Srivastava、V.B. Rana、Madan Mohan、M.P. Swami、P.C. Jain

  DOI：10.1016/0022-1902(75)80528-8

  日期：1975.3

  A series of trivalent lanthanide chelates of α,β-unsaturated-β ketoamines, Ln(apo)3.H2O, Ln(mapo)3.H2O and Ln(anpo)3.H2O, where, Ln = La, Ce, Pr, Sm, Nd, Gd and Dy; apo = 4-amino-3-pentene-2-one; mapo = 4-methylamino-3-pentene-2-one, and anpo = 4-anilino-3-pentene-one, have been prepared and characterized by analyses, magnetic and spectral studies. The magnetic moment values of the new complexes show

  α，β-不饱和-β酮胺，Ln（apo）3 .H 2 O，Ln（mapo）3 .H 2 O和Ln（anpo）3 .H 2 O的一系列三价镧系元素螯合物，其中Ln = La，Ce，Pr，Sm，Nd，Gd和Dy apo＝ 4-氨基-3-戊烯-2-一；mapo = 4-methylamino-3-pentene-2-one和anpo＝ 4-苯胺基-3-戊烯一，已经制备并通过分析，磁和光谱研究表征。新络合物的磁矩值与Van Vleck值几乎没有偏差。红外研究确定了配体通过氮和氧原子与金属离子的配位关系。
• Reactions between enaminones and enones. Part 2. C versus N-Alkylation with cyclohex-2-enone. Structure confirmation by reduction of a dienaminone derivative of dehydrated dimedone dimer
  作者：Ibrahim Chaaban、John V. Greenhill、Mohamed Ramli

  DOI：10.1039/p19810003120

  日期：——

  Primary and secondary enaminones derived from cyclohexane-1,3-dione, dimedone, and acetylacetone react with cyclohexenone to give exclusively C-alkylated derivatives. In every case the products form carbinolamines which exist as 1-hydroxy-2-azacyclo[3.3.1]nonenes. This was confirmed in some examples by formation of an extra ring between nitrogen and oxygen. A series of dienaminones were prepared from

  衍生自环己烷-1，3-二酮，二甲酮和乙酰丙酮的伯和仲烯胺酮与环己烯酮反应，仅得到C-烷基化衍生物。在每种情况下，产物形成甲醇胺，它们以1-羟基-2-氮杂环[3.3.1]壬烯的形式存在。在一些实例中，这通过在氮和氧之间形成额外的环来证实。由2-（5,5-二甲基-3-氧代环己基-1-烯基）-5,5-二甲基环己烷-1,3-二酮制备了一系列的二烯酮，并将其中一个还原成与其相同的氮杂烯酮。C-烷基化。