3,6-dioxaheptylhydrazine | 81866-68-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6-dioxaheptylhydrazine
• 英文别名: [2-(2-methoxyethoxy)-ethyl]-hydrazine；2-(2-methoxyethoxy)ethylhydrazine
• CAS: 81866-68-4
• 化学式: C₅H₁₄N₂O₂
• 分子量: 134.178
• InChiKey: SYFDDJMFJWNYTG-UHFFFAOYSA-N

物化性质

• 沸点：
  234.2±20.0 °C(Predicted)
• 密度：
  0.984±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  56.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,6-dioxaheptylhydrazine 在 camphor-10-sulfonic acid 、 三乙胺 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  [EN] POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
  [FR] COMPOSÉ POLYMÉRISABLE ET CORPS OPTIQUEMENT ANISOTROPE

  摘要：

  提供一种可聚合的组合物，通过该组合物得到的薄膜聚合物在紫外光照射时，不太容易发生变色或排列缺陷。还提供了通过聚合该聚合物组合物得到的聚合物，以及使用该聚合物的光学各向异性体。本发明提供了一种具有由式（Z-0）表示的部分结构的可聚合低波长色散或可聚合反波长色散化合物。此外，本发明提供了一种含有该化合物的组合物；通过聚合该组合物得到的聚合物；以及通过使用该聚合物得到的光学各向异性体。

  公开号：

  WO2017079867A1
• 作为产物：
  描述：

  1-(2-氯乙氧基)-2-甲氧基乙烷 在 一水合肼 作用下， 以 乙醇 为溶剂， 以5.8 g的产率得到3,6-dioxaheptylhydrazine
  参考文献：
  名称：

  METHOD FOR PRODUCING POLYMERIZABLE COMPOUND

  摘要：

  这种可聚合化合物具有醛肟基团。本发明还提供了一种可聚合组合物，其中不容易发生变色和对齐性能降低。此外，本发明提供了一种通过聚合含有通过生产方法获得的化合物的可聚合组合物以及使用聚合物制备光学各向异性体的聚合物。本发明提供了一种生产可聚合化合物的方法，包括将通式（I-B-a）表示的化合物与通式（I-B-b）表示的化合物反应以获得通式（I-C）表示的化合物的步骤，并提供了包含通过这种生产方法获得的化合物的组合物。

  公开号：

  US20180354922A1

文献信息

• Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase
  申请人：Anderson Kevin William

  公开号：US20070225280A1

  公开（公告）日：2007-09-27

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

  本文提供了以下式（I）的化合物： 以及其药学上可接受的盐，其中取代基如规范中所披露的那样。这些化合物及含有它们的药物组合物对于治疗诸如II型糖尿病和代谢综合征等疾病是有用的。
• Adamantyl-pyrazole carboxamides as inhibitors of 11β-hdroxysteroid dehydrogenase
  申请人：Hoffmann-La Roche Inc.

  公开号：US07728029B2

  公开（公告）日：2010-06-01

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

  本文提供了式（I）的化合物及其药学上可接受的盐，其中取代基如规范所述。这些化合物及含有它们的药物组合物，可用于治疗疾病，例如II型糖尿病和代谢综合征。
• Spectroscopic and PM5 semiempirical studies of new hydrazone of gossypol with 3,6-dioxaheptylhydrazine
  作者：Grzegorz Bejcar、Piotr Przybylski、Joanna Fusiara、Bogumil Brzezinski、Franz Bartl

  DOI：10.1016/j.molstruc.2005.05.050

  日期：2005.11

  A new hydrazone of gossypol with 3,6-dioxaheptylhydrazine (GHDO) has been synthesised and its structure has been studied by FT-IR, H-1 NMR, C-13 NMR as well as PM5 semiempirical methods. All the studies have provided clear evidence of the existence of GHDO in the solution in the N-imine-N-imine tautomeric form. The structure and the spectroscopic behaviour of this tautomer are discussed in details. It is shown the structure of GHDO is strongly stabilised by different types of intramolecular hydrogen bonds. In two of them the oxygen atoms of the oxaalkyl chains are also engaged. The strongest intramolecular hydrogen bond is formed between the O7H proton and N-16 atom from the hydrazone group. (c) 2005 Elsevier B.V. All rights reserved.
• Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini
  作者：Piotr Przybylski、Krystian Pyta、Dorota Remlein-Starosta、Grzegorz Schroeder、Bogumil Brzezinski、Franz Bartl

  DOI：10.1016/j.bmcl.2009.02.051

  日期：2009.4

  Eight alkyl and six heterocyclic aza-derivatives of gossypol (2-15) have been synthesized using gossypol (1) extracted from Gossypium Herbaceum cottonseeds. The ability of gossypol aza-derivatives to form complexes with NaClO4 has been investigated by electrospray ionisation (ESI) mass spectra recorded in the positive and negative ion detection modes. The gossypol aza-derivatives have been characterized by FT-IR, H-1 and C-13 NMR spectroscopic methods and subsequently tested for their antifungal properties against Fusarium oxysporum. Four alkyl aza-derivatives (2-5), present in the enamine-enamine tautomeric form, have shown activity comparable or higher than that of gossypol against this fungus. To improve the antifungal activity the complexes of the most active compounds 2-5 with NaClO4 were prepared. Complexes of 2 and 5 with NaClO4 have shown antifungal activity higher than that of the uncomplexed compounds. (C) 2009 Elsevier Ltd. All rights reserved.
• METHOD FOR PRODUCING POLYMERIZABLE COMPOUND
  申请人：DIC Corporation

  公开号：US20180354922A1

  公开（公告）日：2018-12-13

  The polymerizable compound has a hydrazone moiety. The present invention also provides a polymerizable composition in which discoloration and reduction of aligning property do not easily occur. Furthermore, the present invention provides a polymer obtained by polymerizing a polymerizable composition containing a compound obtained by the production method and an optically anisotropic body using the polymer. The present invention provides a method for producing a polymerizable compound including a step of reacting a compound represented by General Formula (I-B-a) with a compound represented by General Formula (I-B-b) to obtain a compound represented by General Formula (I-C), and provides a composition which contains a compound obtained by this production method.

  这种可聚合化合物具有醛肟基团。本发明还提供了一种可聚合组合物，其中不容易发生变色和对齐性能降低。此外，本发明提供了一种通过聚合含有通过生产方法获得的化合物的可聚合组合物以及使用聚合物制备光学各向异性体的聚合物。本发明提供了一种生产可聚合化合物的方法，包括将通式（I-B-a）表示的化合物与通式（I-B-b）表示的化合物反应以获得通式（I-C）表示的化合物的步骤，并提供了包含通过这种生产方法获得的化合物的组合物。