2,4-Hexadienoic acid potassium | 590-00-1

• 物质功能分类: 原料药 - 人工合成抗感染类药 - 消毒防腐药
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,4-Hexadienoic acid potassium
• CAS: 590-00-1
• 化学式: C6H8KO2
• 分子量: 151.22
• InChiKey: OXPHNMOARHEBGH-UHFFFAOYSA-N

物化性质

• 熔点：
  270 °C
• 密度：
  1.3630
• 溶解度：
  H2O: 1 M ， 20 °C，透明，无色至淡黄色
• LogP：
  1.620

计算性质

• 辛醇/水分配系数(LogP)：
  0.82
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26
• 危险类别码：
  R36/37/38
• WGK Germany：
  1
• RTECS号：
  WG2170000
• 海关编码：
  2916190090

SDS

Name:	Potassium sorbate 99% Material Safety Data Sheet
Synonym:	2,4-Hexadienoic acid, potassium salt; Sorbic acid potassium salt; Sorbate, potassiu
CAS:	590-00-1

Section 1 - Chemical Product MSDS Name:Potassium sorbate 99% Material Safety Data Sheet
Synonym:2,4-Hexadienoic acid, potassium salt; Sorbic acid potassium salt; Sorbate, potassiu

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
590-00-1	Potassium sorbate	99	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May cause dermatitis.
Ingestion:
Low hazard for usual industrial handling.
Inhalation:
May cause respiratory tract irritation.
Chronic:
Prolonged or repeated skin contact may cause dermatitis.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use with adequate ventilation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 590-00-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: very light beige
Odor: Characteristic odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 270 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 270 deg C
Solubility in water: 58.2 % (20 c)
Specific Gravity/Density: 1.363 g/mL
Molecular Formula: C6H7KO2
Molecular Weight: 150.22

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 590-00-1: WG2160000 LD50/LC50:
CAS# 590-00-1: Oral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 4340 mg/kg.
Carcinogenicity:
Potassium sorbate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 590-00-1: No information available.
Canada
CAS# 590-00-1 is listed on Canada's DSL List.
CAS# 590-00-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 590-00-1 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

化学性质

山梨酸钾为白色至浅黄色鳞片状结晶、结晶性粉末或呈粒状，无臭或微臭。长期存放于空气中易吸潮并氧化分解而着色。相对密度(d₂₀²⁵)1.363。熔点270℃(分解)。易溶于水（67.6g/100ml，20℃）、5%食盐水（47.5g/100ml，室温）和25%砂糖水（5lg/100ml，室温），还溶于丙二醇（5.8g/100mL）、乙醇（0.3g/100mL）。1%水溶液的pH值为7～8。山梨酸钾有很强的抑制腐败菌和霉菌作用，并因毒性远比其他防腐剂低，已成为世界上最主要的防腐剂之一。在酸性条件下能充分发挥防腐作用，在中性时效果甚微。

用途

在食品工业中作为防腐剂、防霉剂使用。

生产方法

由碳酸钾或氢氧化钾中和山梨酸而得。

类别与毒性分级

• 类别：有毒物质
• 毒性分级：中毒

急性毒性

• 口服 - 大鼠 LD50: 4340 毫克/公斤
• 口服 - 小鼠 LD50: 3800 毫克/公斤

可燃性危险特性

• 可燃：火场排出含氧化钾的辛辣刺激烟雾。

储运特性

• 库房应低温、通风且干燥。

灭火剂

• 水
• 二氧化碳
• 干粉
• 砂土

文献信息

• L-Setastine Hydrochloride and Preparation Method Thereof
  申请人：Huang Qingyun

  公开号：US20140296517A1

  公开（公告）日：2014-10-02

  The present invention relates to the field of medicine, and disclosed are an L-setastine hydrochloride and a preparation method therefor. The compound of the present invention has the advantages of stronger histamine Hi receptor antagonism and small side effect; the yield of the preparation method is more than 80%, and the product purity is high. The present invention also provides an application of the compound as an H1 histamine receptor antagonist.

  本发明涉及医学领域，公开了一种盐酸L-赛丁胺及其制备方法。本发明的化合物具有更强的组胺H1受体拮抗作用和小的副作用；制备方法的产率高于80％，产品纯度高。本发明还提供了该化合物作为H1组胺受体拮抗剂的应用。
• Supplement food for low blood glucose recovery
  申请人：Sasaki Takao

  公开号：US20060034895A1

  公开（公告）日：2006-02-16

  A supplement food which is useful when the diabetic of recuperation at home lapses into low blood glucose condition, and a supplement food for taking in easily, acting quickly to recovering low blood glucose condition, and, moreover, not having durability after recovery. A supplement food having glucose as the principal component, containing glucose in jelly, and contains 10-20 g of glucose in a packaging.

  一种补充食品，适用于糖尿病患者在家恢复期间出现低血糖症状，是一种易于摄入、快速恢复低血糖症状的补充食品，并且在恢复后不会有持久性影响。该补充食品以葡萄糖为主要成分，含有葡萄糖果冻，每包含有10-20克葡萄糖。
• Biochemical oxygen demand analyzer, methods of analysis, microorganisms used for analysis
  申请人：Nakano Vinegar Co., Ltd.

  公开号：EP0543407A1

  公开（公告）日：1993-05-26

  The present invention relates to a BOD analyzer comprising a microbe sensor containing an oxygen electrode and a microbe membrane. The microbe membrane is made by immobilizing microorganisms belonging to the genus Klebsiella in a membrane. Specifically, the present invention relates to a BOD analyzer comprising a flow cell equipped with a microbe sensor containing an oxygen electrode and a microbe membrane; and a liquid passage which is connected with the entrance of the flow cell and which is equipped with an outlet. The microbe membrane is made by immobilizing microorganisms belonging to Klebsiella oxytoca 12092 strain in a porous hydrophilic membrane having an average pore size of 0.65-3 µm in diameter by using at least one gelating agent selected from the group consisting of arginic acid or salts thereof, agar, gellan gum, xanthane gum, gelatine, carageenan, locust bean gum, methylcellulose, pectin, and pullulan. The present invention also relates to improved methods of analyzing BOD by using the BOD analyzer.

  本发明涉及一种生化需氧量分析仪，它包括一个微生物传感器，其中有一个氧电极和一个微生物膜。微生物膜是通过将属于克雷伯氏菌属的微生物固定在膜中制成的。具体而言，本发明涉及一种生化需氧量分析仪，包括一个装有微生物传感器的流动池，该传感器包含一个氧电极和一个微生物膜；以及一个液体通道，该液体通道与流动池的入口相连，并配有一个出口。微生物膜是通过使用至少一种选自精氨酸或其盐、琼脂、结冷胶、黄原胶、明胶、卡拉胶、槐豆胶、甲基纤维素、果胶和拉鲁兰组成的组的凝胶剂，将属于克雷伯氏菌 12092 株的微生物固定在平均孔径为 0.65-3 微米的多孔亲水膜中制成的。本发明还涉及使用生化需氧量分析仪分析生化需氧量的改进方法。
• TOOTHPASTE COMPOSITIONS
  申请人：Lion Corporation

  公开号：EP1236461A1

  公开（公告）日：2002-09-04

  The invention provides a dentifrice composition, which comprises an enzyme and/or an antiplasmin, and an anionic surface active agent, characterized by further comprising a hydroxyethyl cellulose·dimethyldiallylammonium salt, and one or more flavor components (A) selected from the group consisting of anethole, carvone, cineol, methyl salicylate, eugenol, ethyl butylate and cinnamic aldehyde and 1-menthol (B) being contained at a ratio by weight of 1:9 to 8:2.

  本发明提供了一种牙膏组合物，该组合物包含酶和/或抗胰蛋白酶，以及阴离子表面活性剂，其特征在于还包含羟乙基纤维素-二甲基二烯丙基铵盐，以及一种或多种香料成分（A），这些香料成分选自茴香醚、香芹酮、辛醇、水杨酸甲酯、丁香酚、丁酸乙酯和肉桂醛及1-薄荷醇（B）组成的组，其重量比为1：9 至 8:2。
• SUPPLEMENTAL FOOD FOR RECOVERY FROM HYPOGLYCEMIC SYMPTOMS
  申请人：ARKRAY INC.

  公开号：EP1604670A1

  公开（公告）日：2005-12-14

  A supplement food which is useful when the diabetic of recuperation at home lapses into low blood glucose condition, and a supplement food for taking in easily, acting quickly to recovering low blood glucose condition, and, moreover, not having durability after recovery. A supplement food having glucose as the principal component, containing glucose in jelly, and contains 10-20g of glucose in a packaging.

  一种在家中休养的糖尿病患者陷入低血糖状态时有用的补充食品，以及一种易于摄取、对恢复低血糖状态作用迅速，而且在恢复后不会产生耐久性的补充食品。一种以葡萄糖为主要成分的补充食品，果冻中含有葡萄糖，包装中含有 10-20 克葡萄糖。