ethyl 2-oxo-1-oxaspiro[4.6]undecane-4-carboxylate | 33021-07-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: ethyl 2-oxo-1-oxaspiro[4.6]undecane-4-carboxylate
• 英文别名: Ethyl 2-oxo-1-oxaspiro[4.6]undecane-4-carboxylate
• CAS: 33021-07-7
• 化学式: C₁₃H₂₀O₄
• 分子量: 240.299
• InChiKey: WAMSMZZSDVLPNZ-UHFFFAOYSA-N

物化性质

• 沸点：
  381.8±35.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氢化铈 (CeH3) 、 2-溴丁二酸二乙酯 、 环庚酮 在 碘 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 1,1'-bicycloheptanediol 、 ethyl 2-oxo-1-oxaspiro[4.6]undecane-4-carboxylate
  参考文献：
  名称：

  Cerium metal- mediated Reformatsky-type reaction with ethyl bromosuccinate for the synthesis of novel paraconic acid analogs

  摘要：

  The treatment of cerium metal with ethyl bromosuccinate (1) forms the stabilized organolanthanoid intermediate (2), which reacts with carbonyl compounds in a Reformatsky-type reaction, under mild conditions, to produce functionalized gamma-substituted paraconic acids (4) in good yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.155

文献信息

• Cerium metal- mediated Reformatsky-type reaction with ethyl bromosuccinate for the synthesis of novel paraconic acid analogs
  作者：Shirley M.M. Rodrigues、Viviani Nardini、Mauricio G. Constantino、Gil Valdo J. da Silva

  DOI：10.1016/j.tetlet.2012.08.155

  日期：2012.11

  The treatment of cerium metal with ethyl bromosuccinate (1) forms the stabilized organolanthanoid intermediate (2), which reacts with carbonyl compounds in a Reformatsky-type reaction, under mild conditions, to produce functionalized gamma-substituted paraconic acids (4) in good yields. (C) 2012 Elsevier Ltd. All rights reserved.