bis-(3,3-dichloro-propyl)-ether | 108106-75-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bis-(3,3-dichloro-propyl)-ether
• 英文别名: Bis-(3,3-dichlor-propyl)-aether；Dichloropropylether；1,1-dichloro-3-(3,3-dichloropropoxy)propane
• CAS: 108106-75-8
• 化学式: C₆H₁₀Cl₄O
• 分子量: 239.957
• InChiKey: LFNRXCLLMPFWPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二氯甲基醚 、 氯乙烯 在 氯化锑(V) 作用下， 生成 bis-(3,3-dichloro-propyl)-ether
  参考文献：
  名称：

  DE898588

  摘要：

  公开号：

文献信息

• [EN] PNA MONOMER AND PRECURSOR<br/>[FR] MONOMERE ET PRECURSEUR PNA
  申请人：PANAGENE INC

  公开号：WO2003091231A1

  公开（公告）日：2003-11-06

  This application relates to monomers of the general formula (I) for the preparation PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: (I) wherein E is nitrogen or C-R'; J is sulfur or oxygen; R', Rl, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, RS is H or protected or unprotected side chain of natural or unnatural a-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

  该应用程序涉及通用式(I)的单体，用于制备PNA（肽核酸）寡聚体，并提供了合成预定义序列PNA寡聚体和随机序列PNA寡聚体的方法：(I)其中E为氮或C-R'; J为硫或氧; R'，Rl，R2，R3，R4独立地为H，卤素，烷基，硝基，腈基，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，RS为H或天然或非天然α-氨基酸的保护或未保护侧链; B为天然或非天然核碱基，其中当所述核碱基具有外环氨基功能时，所述功能由对酸敏感但在巯基存在下对弱到中等碱稳定的保护基保护。
• PNA monomer and precursor
  申请人：——

  公开号：US20030225252A1

  公开（公告）日：2003-12-04

  This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: 1 wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural &agr;-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

  该应用程序涉及通式（I）的单体，用于制备PNA（肽核酸）寡聚体，并提供了合成预定义序列PNA寡聚体和随机序列PNA寡聚体的方法： 其中 E为氮或C—R′；J为硫或氧； R′、R1、R2、R3、R4独立地为H、卤素、烷基、硝基、腈基、烷氧基、卤代烷基、卤代烷氧基、苯基或卤代苯基， R5为H或天然或非天然α-氨基酸的保护或未保护侧链；以及 B为天然或非天然核碱基，其中当所述核碱基具有外环氨基功能时，所述功能由对酸敏感但在巯基存在下对弱到中等碱稳定的保护基保护。
• [EN] PROCESS FOR HYDROGENATING DICHLOROISOPROPYL ETHER<br/>[FR] PROCÉDÉ D'HYDROGÉNATION D'ÉTHER DE DICHLOROISOPROPYLE
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2016044009A1

  公开（公告）日：2016-03-24

  Convert dichloroisopropyl ether into a halogenated derivative by contacting the dichloroisopropyl ether with a source of hydrogen and a select heterogeneous hydrogenation catalyst under process conditions selected from a combination of a temperature within a range of from 50 degrees centigrade (ºC) to 350 ºC, a pressure within a range of from atmospheric pressure (0.1 megapascals) to 1000 pounds per square inch (6.9 MPa), a liquid feed volume flow to catalyst mass ratio between 0.5 and 10 L/Kg*h and a volume hydrogen / volume liquid ratio between 100 and 5000 ml gas/ ml liquid. The halogenated derivative is at least one of 1-chloro-2-propanol and 1,2-dichloropropane 1, and glycerin monochlorohydrin.

  通过将二氯异丙醚与氢源和选择性的杂化氢化催化剂接触，在从以下过程条件的组合中选择的条件下，将二氯异丙醚转化为卤代衍生物：温度在50摄氏度（ºC）至350ºC范围内，压力在大气压（0.1兆帕）至1000磅每平方英寸（6.9兆帕）范围内，液体进料体积流量与催化剂质量之比在0.5至10 L/Kg*h之间，氢气体积/液体体积比在100至5000 ml气体/ ml液体之间。卤代衍生物至少为1-氯-2-丙醇和1,2-二氯丙烷1，以及甘油单氯水合物。
• PROCESS FOR PREPARING SUBSTITUTED ACETALS OF MALONDIALDEHYDE
  申请人：——

  公开号：US20020040166A1

  公开（公告）日：2002-04-04

  A process directed to the preparation of 2-substituted and 2,2-disubstituted acetals of malondialdehyde from ortho formates and substituted vinyl ethers in the presence of an acidic catalyst.

  一种制备2-取代和2,2-二取代马隆二醛缩醛的过程，在酸性催化剂的存在下，使用正甲酸酯和取代乙烯醚。
• Guanidinylation reagents
  申请人：The Regents of The University of California

  公开号：US20030055214A1

  公开（公告）日：2003-03-20

  Trisubstituted N-protected guanidines and methods for use as guanidinylating reagents to yield N-protected guanidine derivatives.

  三取代N-保护胍和用作胍基化试剂的方法，以产生N-保护胍衍生物。