5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid | 42835-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
• 英文别名: 5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid；6,7-Dihydro-5-methyl-1-oxo-1H,5H-benzochinolizin-2-carbonsaeure；6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]-quinolizine-2-carboxylic acid；12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
• CAS: 42835-34-7
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: QDQSXXDXQDTVJY-UHFFFAOYSA-N

物化性质

• 沸点：
  416.8±45.0 °C(Predicted)
• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  triethylamine salt of cephaloglycine 、 5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid 、 头孢来星 、 氯甲酸异丁酯 、 正丁醇 、 sodium 2-ethylhexanoic acid 生成 (6R)-3-acetoxymethyl-7t-[(R)-2-((Ξ)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carbonylamino)-2-phenyl-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine
  申请人：RIKER LABORATORIES, INCORPORATED

  公开号：EP0079162A1

  公开（公告）日：1983-05-18

  This invention relates to antimicrobial compounds of the ormula wherein X is hydrogen or fluorine; Y is selected from the group consisting of -CH2NH2, and esters, carboxylate salts, and alkylaminoalkyl ester salts thereof.

  本发明涉及如下抗菌化合物 其中 X 是氢或氟；Y 选自 -CH2NH2 组成的组、 及其酯、羧酸盐和烷基氨基烷基酯盐组成的组。
• 6,7-Dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid and derivatives
  申请人：RIKER LABORATORIES, INC.

  公开号：EP0109284A1

  公开（公告）日：1984-05-23

  The compound 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo--1 H,5H-benzo[ij]quinolizine-2-carboxylic acid is disclosed as a potent antimicrobial agent with a broad spectrum of activity. Esters, acyl chlorides, alkylaminoalkyl ester salts and pharmaceutically acceptable carboxylate salts of the acid are also disclosed. Methods of using these compounds, pharmaceutical compositions comprising these compounds and synthetic intermediates for preparing these compounds are described.

  6,7-二氢-5,8-二甲基-9-氟-1-氧代-1 H,5H-苯并[ij]喹嗪-2-羧酸是一种具有广谱活性的强效抗菌剂。此外，还公开了该酸的酯类、酰基氯化物、烷基氨基烷基酯盐和药学上可接受的羧酸盐。还介绍了使用这些化合物的方法、包含这些化合物的药物组合物以及制备这些化合物的合成中间体。
• 6,7-Dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acids and derivatives
  申请人：RIKER LABORATORIES, INC.

  公开号：EP0109285A1

  公开（公告）日：1984-05-23

  Certain 6,7-dihydro-8-limidazol-1-yp-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids are disclosed as potent antimicrobial agents with an unusual spectrum of activity. Esters, acyl chlorides, alkylaminoalkyl ester salts, salts of a nitrogen atom of the imidazole ring, and pharmaceutically acceptable carboxylate salts are also disclosed. Novel synthetic intermediates are also described.

  本研究公开了某些 6,7-二氢-8-咪唑-1-基-1-氧代-1H,5H-苯并[ij]喹嗪-2-羧酸，它们是具有不同寻常活性谱的强效抗菌剂。此外，还公开了酯类、酰基氯化物、烷基氨基烷基酯盐、咪唑环氮原子盐和药学上可接受的羧酸盐。还描述了新型合成中间体。
• 8-Alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acids
  申请人：RIKER LABORATORIES, INCORPORATED

  公开号：EP0119779A1

  公开（公告）日：1984-09-26

  The 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo--1H,5H-benzo[ij]quinolizine-2-carboxylic acids are disclosed as potent antimicrobial agents with a broad spectrum of activity. Esters, acyl chlorides, amides, alkylaminoalkyl ester salts and pharmaceutically acceptable carboxylate salts are also disclosed. Methods of using these compounds, pharmaceutical compositions comprising these compounds and synthetic intermediates for preparing these compounds are also described.

  公开了 8-烷氧基-6,7-二氢-5-甲基-9-氟-1-氧代-1H,5H-苯并[ij]喹嗪-2-羧酸，它们是具有广谱活性的强效抗菌剂。 此外，还公开了酯类、酰基氯化物、酰胺、烷基氨基烷基酯盐和药学上可接受的羧酸盐。 还描述了使用这些化合物的方法、包含这些化合物的药物组合物以及制备这些化合物的合成中间体。
• (S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS
  申请人：Wockhardt Limited

  公开号：EP1175217B8

  公开（公告）日：2009-03-18