Artemether and lumefantrine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Artemether and lumefantrine
• 英文别名: 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol;(4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
• 化学式: C46H58Cl3NO6
• 分子量: 827.3
• InChiKey: ZVAQGQOEHFIYMQ-PRLJFWCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.99
• 重原子数：
  56
• 可旋转键数：
  11
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

毒理性

• 在妊娠和哺乳期间的影响

◉ 母乳喂养期间使用总结：青蒿琥酯和卢美吩噻尚未在哺乳期母亲中进行研究。估计其排入母乳中的量非常低。美国疾病控制与预防中心认为这种药物组合可用于哺乳至少5公斤（11磅）婴儿的母亲，并且可以直接给予体重为5公斤或以上的婴儿。对于5公斤以下母乳喂养婴儿的安全性尚不清楚。药片可以压碎并随母乳一起给予，以增加小婴儿的吸收。 ◉ 对母乳喂养婴儿的影响：截至修订日期，未找到相关已发布信息。 ◉ 对泌乳和母乳的影响：截至修订日期，未找到相关已发布信息。

◉ Summary of Use during Lactation:Artemether and lumefantrine have not been studied in nursing mothers. Estimates of its excretion into breastmilk indicate that amounts in milk are very low. The Centers for Disease Control and Prevention consider the drug combination acceptable for use in mothers nursing an infant weighing at least 5 kg (11 pounds) and it can be given directly to infants weighing 5 kg or more. The safety of the combination in breastfed infants under 5 kg is not known. Tablets can be crushed and administered in breastmilk to enhance absorption in small infants. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)