10-methylacridinium methyl sulfate | 6277-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-methylacridinium methyl sulfate
• 英文别名: N-methylacridinium methyl sulfate；10-methylacridin-10-ium;methyl sulfate
• CAS: 6277-44-7
• 化学式: CH₃O₄S*C₁₄H₁₂N
• 分子量: 305.354
• InChiKey: DVOXVUAOBKXFHG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.91
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  78.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  10-methylacridinium methyl sulfate 在 potassium tert-butylate 、 氧气 作用下， 以 二甲基亚砜 为溶剂， 以97%的产率得到甲基-蒽酮
  参考文献：
  名称：

  Base-induced Oxygenation and Chemiluminescence of 10-Methylacridinium and 1-Methylquinolinium Salts in Dimethyl Sulfoxide

  摘要：

  由于 10-甲基-9(10H)-吖啶酮和 1-甲基-1(4H)-喹啉酮的荧光激发到其 S1 状态，当在二甲基亚砜（DMSO）中存在叔丁氧（t-BuOK）时，10-甲基吖啶鎓甲基硫酸盐和 1-甲基喹啉鎓盐在与基态氧氧化时发出强烈的光辐射。

  DOI：

  10.1246/bcsj.56.1519
• 作为产物：
  描述：

  吖啶 、 硫酸二甲酯 以53%的产率得到10-methylacridinium methyl sulfate
  参考文献：
  名称：

  Synthesis of terminally substituted 9-alkylidene-10-methyl acridans

  摘要：

  DOI：

  10.1007/bf00808767

文献信息

• Oxidative SNH amidation of acridine and tautomerism of N-(acridin-9-yl)benzamides
  作者：Oleg P. Demidov、Ivan V. Borovlev、Gulminat A. Amangasieva、Elena K. Avakyan

  DOI：10.1007/s10593-016-1841-7

  日期：2016.2

  Direct oxidative nucleophilic substitution of hydrogen atom in acridine molecule was used to synthesize 9-acylaminoacridines. The prototropic amine-imine tautomerism of these compounds was studied.

  a啶分子中氢原子的直接氧化亲核取代反应用于合成9-酰基氨基ac啶。研究了这些化合物的质子型胺亚胺互变异构现象。
• Nucleophilic Addition of Amides to 10-Alkylacridinium Cations: A Case of Double N-Nucleophilicity of Some Monoamides
  作者：Ivan Borovlev、Oleg Demidov、Gulminat Amangasieva、Elena Avakyan

  DOI：10.1055/s-0036-1588786

  日期：2017.8

  Abstract An effective synthesis of N-(10-alkyl-9,10-dihydroacridin-9-yl) derivatives of amides, ureas, and urethanes has been developed. Additionally, the spatially overloaded molecules of N,N-bis(10-alkyl-9,10-dihydroacridin-9-yl)acrylamide were obtained in the case of formamide and acrylamide. An effective synthesis of N-(10-alkyl-9,10-dihydroacridin-9-yl) derivatives of amides, ureas, and urethanes

  摘要 已经开发出酰胺，脲和氨基甲酸酯的N-（10-烷基-9,10-二氢ac啶-9-基）衍生物的有效合成。另外，在甲酰胺和丙烯酰胺的情况下，获得了N，N-双（10-烷基-9,10-二氢ac啶-9-基）丙烯酰胺的空间过载分子。 已经开发出酰胺，脲和氨基甲酸酯的N-（10-烷基-9,10-二氢ac啶-9-基）衍生物的有效合成。另外，在甲酰胺和丙烯酰胺的情况下，获得了N，N-双（10-烷基-9,10-二氢ac啶-9-基）丙烯酰胺的空间过载分子。
• Preparation and Properties of AzaTCNQ⁻Anion Salts and Mixed AzaTCNQ⁻/TCNQ^\ewdotSalts of<i>N</i>-Alkylpyridinium and Related Cations
  作者：Hirohisa Tanaka、Gen-etsu Matsubayashi、Toshio Tanaka

  DOI：10.1246/bcsj.57.2198

  日期：1984.8

  The [Cation]+ATCNQ− type salts were prepared, where ATCNQ− is (4-dicyanomethyl-1-pyridinio)dicyanomethanide anion, so-called AzaTCNQ− anion, and [Cation]+ are N-alkylpyridinium, 4-cyano-N-alkylpyridinium, (4-methyl-1-pyrazinio)dicyanomethanide, N-alkylquinolinium (alkyl=Me and Et), N-methylacridinium, and N-methylphenazinium. Electrical resistivities of these salts as compacted samples fall in the

  制备了 [Cation]+ATCNQ− 型盐，其中 ATCNQ− 是 (4-dicyanomethyl-1-pyridinio)dicyanomethanide 阴离子，即所谓的 AzaTCNQ− 阴离子，[Cation]+ 是 N-烷基吡啶鎓，4-氰基-N -烷基吡啶鎓、(4-甲基-1-吡嗪鎓)二氰基甲烷化物、N-烷基喹啉鎓（烷基=Me和Et）、N-甲基吖啶鎓和N-甲基吩嗪鎓。这些盐作为压实样品的电阻率在 25°C 时落在 106-109 Ωcm 的范围内。还制备了N-烷基吡啶鎓和-喹啉鎓阳离子的混合ATCNQ-/TCNQ\ewdot盐（TCNQ\ewdot=7,7,8,8-四氰基-对醌二甲烷自由基阴离子）；[Cation]+ (ATCNQ−)0.1(TCNQ\ewdot)0.9([Cation]+=N-methylpyridinium, N-ethylpyridinium, and N-ethylquinolinium)
• Optical-chemical Sensor
  申请人：F. Hoffman-La Roche AG

  公开号：US20020034826A1

  公开（公告）日：2002-03-21

  An optical-chemical sensor which is suitable for the continuous and discontinuous determination by luminescence optics of the concentration of chloride in an aqueous sample and which comprises a luminescence indicator (I) and a polymer (H) carrying the luminescence indicator (I) is characterized in that the luminescence indicator (I) is a non-lipophile acridine or bisacridine compound and the polymer (H) is a linear-chain hydrophile polymer soluble in an organic solvent, whereby it is possible to excite the sensor by commercially available LEDs, to manufacture very large numbers thereof at a moderate cost and in a reproducible way and, preferably, to use it for the determination of physiological chloride concentrations and the sensor furthermore has a wide dynamic measuring range for the determination of chloride; a high sensitivity, stability and reproducibility; a high selectivity for chloride; and a low pH cross-sensitivity.

  一种光学-化学传感器，适用于通过发光光学连续或不连续地测定水样中的氯化物浓度，该传感器由发光指示剂（I）和携带发光指示剂（I）的聚合物（H）组成，其特征在于发光指示剂（I）是非亲脂性吖啶或双吖啶化合物，聚合物（H）是可溶于有机溶剂的线性链亲水聚合物、这样就可以用市面上的发光二极管来激发传感器，以适中的成本和可重复的方式制造出大量的传感器，最好还能将其用于测定生理氯化物浓度，而且该传感器在测定氯化物时具有很宽的动态测量范围；高灵敏度、稳定性和可重复性；对氯化物的高选择性；低 pH 交叉敏感性。
• Optical-chemical sensor
  申请人：F. Hoffman-La Roche AG

  公开号：US20030101803A1

  公开（公告）日：2003-06-05

  An optical-chemical sensor which is suitable for the continuous and discontinuous determination by luminescence optics of the concentration of chloride in an aqueous sample and which comprises a luminescence indicator (I) and a polymer (H) carrying the luminescence indicator (I) is characterized in that the luminescence indicator (I) is a non-lipophile acridine or bisacridine compound and the polymer (H) is a linear-chain hydrophile polymer soluble in an organic solvent, whereby it is possible to excite the sensor by commercially available LEDs, to manufacture very large numbers thereof at a moderate cost and in a reproducible way and, preferably, to use it for the determination of physiological chloride concentrations and the sensor furthermore has a wide dynamic measuring range for the determination of chloride; a high sensitivity, stability and reproducibility; a high selectivity for chloride; and a low pH cross-sensitivity.

  一种光学-化学传感器，适用于通过发光光学连续或不连续地测定水样中的氯化物浓度，该传感器由发光指示剂（I）和携带发光指示剂（I）的聚合物（H）组成，其特征在于发光指示剂（I）是非亲脂性吖啶或双吖啶化合物，聚合物（H）是可溶于有机溶剂的线性链亲水聚合物、这样就可以用市面上的发光二极管来激发传感器，以适中的成本和可重复的方式制造出大量的传感器，最好还能将其用于测定生理氯化物浓度，而且该传感器在测定氯化物时具有很宽的动态测量范围；高灵敏度、稳定性和可重复性；对氯化物的高选择性；低 pH 交叉敏感性。