4-ethyl-4-methyloxetan-2-one | 4288-03-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4-ethyl-4-methyloxetan-2-one
• 英文别名: 4-Methyl-4-ethyloxetan-2-one
• CAS: 4288-03-3
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: JVMWNSRKQYGZHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基-丁烯 在 bis(tetrahydrofuran)octaethylporphyrinato aluminum tetracarbonyl cobaltate 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 异丙醚 为溶剂， 22.0 ℃ 、6.21 MPa 条件下， 反应 24.0h， 生成 4-ethyl-4-methyloxetan-2-one
  参考文献：
  名称：

  2,2-二取代环氧化物的区域选择性羰基化：酮基羟醛产品的替代途径

  摘要：

  我们报告了 2,2-二取代环氧化物到 β,β-二取代 β-内酯的区域选择性羰基化。机理研究表明，环氧化物开环是周转限制步骤，这一见解有助于使用弱供体的醚溶剂开发改进的反应条件。广泛的环氧化物可以羰基化为 β-内酯，随后开环产生基于酮的醛醇加合物，为 Mukaiyama 醛醇反应提供替代方案。对映纯的环氧化物被证明经过羰基化/开环过程并保留立体化学以形成对映纯的 β-羟基酯。

  DOI：

  10.1021/jacs.8b12286

文献信息

• [EN] SYSTEMS AND METHODS FOR REGIOSELECTIVE CARBONYLATION OF 2,2-DISUBSTITUTED EPOXIDES<br/>[FR] SYSTÈMES ET PROCÉDÉS DE CARBONYLATION RÉGIOSÉLECTIVE D'ÉPOXYDES 2,2-DISUBSTITUÉS
  申请人：UNIV CORNELL

  公开号：WO2020102816A1

  公开（公告）日：2020-05-22

  Provided are methods of carbonylating cyclic substrates to produce carbonyl ated cyclic products. The cyclic substrates may be 2, 2-di substituted epoxides and the cyclic products may be β,β-di substituted lactones. The method may be carried out by forming and pressurizing a reaction mixture of the cyclic substrate, a solvent, carbon monoxide, and a [LA+][CO(CO)4-] catalyst, where [LA+] is a Lewis acid capable of coordinating to the cyclic substrate. The method may proceed with a regioselectivity of 90:10 or greater. The resulting carbonylated cyclic products may be converted to ketone aldol products that retain the stereochemistry and enantiomeric ratio of the carbonyl ated cyclic products.

  提供了一种将环状底物羰基化以产生羰基化环状产物的方法。环状底物可以是2,2-二取代环氧化物，环状产物可以是β,β-二取代内酯。该方法可以通过形成并加压环状底物、溶剂、一氧化碳和[LA+][CO(CO)4-]催化剂的反应混合物来进行，其中[LA+]是能够与环状底物配位的路易斯酸。该方法可能以90:10或更高的区域选择性进行。所得的羰基化环状产物可以转化为保留羰基化环状产物的立体化学和对映比的酮醇产物。
• SUSTAINED RELEASE COMPOSITIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1291023A1

  公开（公告）日：2003-03-12

  A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

  通过含有或混合生理活性非肽物质和具有两个或两个以上羧基末端的可生物降解聚合物或其盐制备的组合物具有以下特点：（1）可以含有更多生理活性非肽物质，并且可以控制或加速其释放，从而实现安全的药效；（2）当生理活性非肽物质引起皮下刺激时，预计具有在其末端具有强酸性基团的活性来取消刺激；以及（3）高玻璃转变温度和高稳定性。
• Sustained release compositions
  申请人：——

  公开号：US20040023987A1

  公开（公告）日：2004-02-05

  A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

  这是一篇有关于含有生理活性非肽物质和生物可降解聚合物的组合物的描述。该生物可降解聚合物在其末端具有两个或多个羧基或其盐，其特点是：（1）可以包含更多生理活性非肽物质，同时可以控制或加速其释放，从而实现安全的药物效果；（2）当生理活性非肽物质引起皮下刺激时，预计其末端的强酸性基团具有消除刺激的作用；（3）具有高玻璃转移温度和高稳定性。
• Polyhydroxyalkanoate having vinyl group, ester group, carboxyl group, and sulfonic group, and method of producing the same
  申请人：Kenmoku Takashi

  公开号：US20070073006A1

  公开（公告）日：2007-03-29

  To provide a novel polyhydroxyalkanoate having a reactive functional group in a molecule and a method of producing the same; and a novel polyhydroxyalkanoate having a new function obtained by chemically modifying the polyhydroxyalkanoate having a reactive functional group and a method of producing the same. By utilizing a vinyl group of a polyhydroxyalkanoate containing a unit having the vinyl group at a side chain thereof, a polyhydroxyalkanoate containing units having a carboxyl group, an amide group, and a sulfonic group in a molecule is induced.

  提供一种分子中具有反应性功能基团的新型聚羟基脂肪酸酯及其制备方法；以及通过化学修饰具有反应性功能基团的聚羟基脂肪酸酯获得的具有新功能的新型聚羟基脂肪酸酯及其制备方法。通过利用聚羟基脂肪酸酯中含有侧链上乙烯基的单元的乙烯基，诱导聚羟基脂肪酸酯中含有羧基、酰胺基和磺酸基的单元。
• Polyhydroxyalkanoic Acid Having Vinyl, Ester, Carboxyl or Sulfonic Acid Group and Producing Method Therefor
  申请人：Kenmoku Takashi

  公开号：US20080064828A1

  公开（公告）日：2008-03-13

  The invention is to provide a novel polyhydroxyalkanoate having a reactive function group within the molecule and a producing method therefor In a polyhydroxyalkanoate containing a unit having a vinyl group in a side chain, such vinyl group is utilized for deriving a polyhydroxyalkanoate comprising a carboxyl group or a unit having an amide group and a sulfonic acid group.

  本发明旨在提供一种新型聚羟基烷酸酯，其分子内具有反应性功能团，并提供其制备方法。在含有侧链中具有乙烯基团的聚羟基烷酸酯中，利用该乙烯基团来获得含有羧基或含有酰胺基和磺酸基的聚羟基烷酸酯。