(RS)-(2Z,6E,10E)-4-methylgeranylgeranyl diphosphate | 125310-45-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (RS)-(2Z,6E,10E)-4-methylgeranylgeranyl diphosphate
• 英文别名: [(2Z,6E,10E)-3,4,7,11,15-pentamethylhexadeca-2,6,10,14-tetraenyl] phosphono hydrogen phosphate
• CAS: 125310-45-4
• 化学式: C₂₁H₃₈O₇P₂
• 分子量: 464.476
• InChiKey: YGVYSWYSYMXWFV-ZZSSLDOYSA-N

物化性质

• 沸点：
  589.8±60.0 °C(predicted)
• 密度：
  1.153±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  反,反-氯化法呢酯 在 氢氧化钾 、 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 19.0h， 生成 (RS)-(2Z,6E,10E)-4-methylgeranylgeranyl diphosphate
  参考文献：
  名称：

  Undecaprenyl diphosphate synthase reaction with artificial substrate homologues — novel behavior in the termination of prenyl chain elongation

  摘要：

  DOI：

  10.1016/s0040-4020(01)85127-9

文献信息

• Crystal structure of staphylococcus undecaprenyl pyrophosphate synthase and uses thereof
  申请人：Ammirati Mark

  公开号：US20050208639A1

  公开（公告）日：2005-09-22

  The invention is directed generally to the structure of prenyltransferases, particularly undecaprenyl pyrophosphate synthase, an enzyme important in bacterial cell wall synthesis. The invention relates to the crystal structure of undecaprenyl pyrophosphate synthase from Staphylococcus aureus and the interaction with a cofactor and ligands. The invention also relates to the structure of ligand and cofactor binding sites.

  本发明一般涉及前烯丙基转移酶的结构，特别是焦磷酸十一烯丙基合成酶，这是一种在细菌细胞壁合成中非常重要的酶。本发明涉及金黄色葡萄球菌焦磷酸十一烯丙基合成酶的晶体结构。 金黄色葡萄球菌 以及与辅助因子和配体的相互作用。本发明还涉及配体和辅助因子结合位点的结构。
• OGURA, KYOZO;KOYAMA, TANETOSHI;OHNUMA, SHIN-ICHI;ITO, MICHIO;JIANYU, SONG, ASAXI GARASU GIDZYUTSU KOGE SEREHJKAJ KEHNKYU XOKOKU, 55,(1989) S. 27-36
  作者：OGURA, KYOZO、KOYAMA, TANETOSHI、OHNUMA, SHIN-ICHI、ITO, MICHIO、JIANYU, SONG

  DOI：——

  日期：——
• CRYSTAL STRUCTURE OF i STAPHYLOCOCCUS /i UNDECAPRENYL PYROPHOSPHATE SYNTHASE AND USES THEREOF
  申请人：Pfizer Products Inc.

  公开号：EP1556483A1

  公开（公告）日：2005-07-27
• EP1611234A2
  申请人：——

  公开号：EP1611234A2

  公开（公告）日：2006-01-04
• Crystal structures of streptococcus undecaprenyl pyrophosphate synthase and uses thereof
  申请人：Pfizer Inc

  公开号：US20040191271A1

  公开（公告）日：2004-09-30

  The invention is directed generally to the structure of prenyltransferases, particularly undecaprenyl pyrophosphate synthase, an enzyme important in bacterial cell wall synthesis. The invention relates to the crystal structure of undecaprenyl pyrophosphate synthase from Streptococcus pneumoniae and its interaction with cofactors and ligands. The invention also relates to the structure of ligand and cofactor binding sites of undecaprenyl pyrophosphate synthase.