N-[2-(4-Acetylphenyl)ethyl]-2,2,2-trifluoroacetamide | 193350-74-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[2-(4-Acetylphenyl)ethyl]-2,2,2-trifluoroacetamide
• 英文别名: N-{2-(4-acetylphenyl)ethyl}-2,2,2-trifluoroacetamide
• CAS: 193350-74-2
• 化学式: C₁₂H₁₂F₃NO₂
• 分子量: 259.228
• InChiKey: ZAPGMMBIMSVFHG-UHFFFAOYSA-N

物化性质

• 沸点：
  381.0±42.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  磷酰基乙酸三乙酯 、 N-[2-(4-Acetylphenyl)ethyl]-2,2,2-trifluoroacetamide 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.53h， 生成 ethyl 3-[4-[2-(2,2,2-trifluoroacetylamino)ethyl]phenyl]but-2-enoate
  参考文献：
  名称：

  EP1443041

  摘要：

  公开号：
• 作为产物：
  描述：

  2,2,2-trifluoro-N-(2-phenylethyl)acetamide 、 乙酰氯 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 N-[2-(4-Acetylphenyl)ethyl]-2,2,2-trifluoroacetamide
  参考文献：
  名称：

  EP1443041

  摘要：

  公开号：

文献信息

• Anti-herpesvirus compounds and methods for identifying, making and using
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US06057451A1

  公开（公告）日：2000-05-02

  This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.

  这项发明涉及通过抑制疱疹螺旋酶-引物酶复合物来抑制疱疹复制并治疗哺乳动物体内的疱疹感染的方法。这项发明还涉及抑制疱疹螺旋酶-引物酶的噻唑苯基衍生物，以及包含这些噻唑苯基衍生物的药物组合物，以及使用和生产这些噻唑苯基衍生物的方法。
• 5-amidino-2-hydroxybenzenesulfonamide derivatives medicinal compoistions containing the same medicinal use thereof and intermediates in the production thereof
  申请人：Uchida Masahiko

  公开号：US20050014787A1

  公开（公告）日：2005-01-20

  The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R 1 is an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkenyl group, a cycloalkyl group or a lower acyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom or a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same and an intermediate thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer's diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.

  本发明涉及一种5-酰胺基-2-羟基苯磺酰胺衍生物，其通式表示为：其中，R1是可选取的取代的低烷基，可选取的取代的低烷氧基，可选取的取代的低烯基，环烷基或低酰基等；Q是氢原子或可选取的取代的低烷基；Z是氢原子或羟基等，或其药学上可接受的盐。该衍生物具有强效和选择性的激活血凝因子X抑制活性，可用作预防或治疗与激活血凝因子X相关的疾病的药物，以及包含该衍生物和其中间体的制药组合物。这些化合物可用作各种疾病的预防或治疗，例如脑梗死、脑血栓形成、脑栓塞、短暂性脑缺血发作、脑血管抽搐、阿尔茨海默病、心肌梗死、心脏病发作、心力衰竭、血栓形成、肺梗死和肺栓塞。
• 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1443041A1

  公开（公告）日：2004-08-04

  The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkenyl group, a cycloalkyl group or a lower acyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom or a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same and an intermediate thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer's diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.

  本发明涉及由通式表示的 5-脒基-2-羟基苯磺酰胺衍生物： 其中 R1 是任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级烯基、环烷基或低级酰基等； Q 是氢原子或任选取代的低级烷基；以及 Z 是氢原子或羟基等、 或其药学上可接受的盐，它们具有强效和选择性的活化血液凝固因子 X 抑制活性，可用作预防或治疗与活化血液凝固因子 X 有关的疾病的药物、由其组成的药物组合物及其中间体。这些化合物可用于预防或治疗各种疾病，如脑梗塞、脑血栓、脑栓塞、TIA、脑血管痉挛、老年痴呆症、心肌梗塞、心脏病、心力衰竭、血栓形成、肺梗塞和肺栓塞。
• PHENYL THIAZOLE DERIVATIVES WITH ANTI HERPES VIRUS PROPERTIES
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP0871619A1

  公开（公告）日：1998-10-21
• US6057451A
  申请人：——

  公开号：US6057451A

  公开（公告）日：2000-05-02