(5Z)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylic acid | 52077-55-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (5Z)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylic acid
• CAS: 52077-55-1
• 化学式: C₂₄H₃₀O₁₃
• 分子量: 526.5
• InChiKey: HKVGJQVJNQRJPO-OIXVIMQBSA-N

物化性质

• 沸点：
  803.9±65.0 °C(Predicted)
• 密度：
  1.57±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• 熔点：
  145-147°C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  213
• 氢给体数：
  7
• 氢受体数：
  13

文献信息

• Compositions and Methods for Treating Obesity, Obesity Related Disorders and for Inhibiting the Infectivity of Human Immunodeficiency Virus
  申请人：The General Hospital Corporation

  公开号：US20140296141A1

  公开（公告）日：2014-10-02

  The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

  本发明涉及使用欧洲橄榄苷、其类似物或衍生物，或欧洲橄榄苷的主要代谢产物，包括欧洲橄榄苷苷元、羟基酪醇和羟基酪醛酸或其类似物或衍生物、半萜苷苷元或半萜苷苷元类似物或衍生物，或上述任何组合物，包括橄榄叶提取物，用于治疗患有或易于发展肥胖症或肥胖相关疾病的受体，或用于抑制HIV的感染。本发明还涉及通过测量个体中PPARγ2、LPL和αP2基因和基因产物或其他脂肪生成、脂肪生成或脂肪分解基因和基因产物的表达谱来筛选/诊断患有或易于患有肥胖症或相关疾病的受体的方法。本发明还提供筛选新的欧洲橄榄苷类似物的方法。
• US8574635B2
  申请人：——

  公开号：US8574635B2

  公开（公告）日：2013-11-05
• US9132145B2
  申请人：——

  公开号：US9132145B2

  公开（公告）日：2015-09-15