(E)-1-(3-(1-phenylprop-1-en-2-yl)furan-2-yl)ethanone | 1228117-80-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-1-(3-(1-phenylprop-1-en-2-yl)furan-2-yl)ethanone
• 英文别名: 1-[3-[(E)-1-phenylprop-1-en-2-yl]furan-2-yl]ethanone
• CAS: 1228117-80-3
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: HSIQRFUBJCPUAC-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-苯基-1-丙炔 、 2-乙酰基呋喃 在 tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate 、 三甲基乙酰氯 作用下， 以 醋酸异丙酯 为溶剂， 反应 16.0h， 以91%的产率得到(E)-1-(3-(1-phenylprop-1-en-2-yl)furan-2-yl)ethanone
  参考文献：
  名称：

  Rhodium(III)-Catalyzed Intermolecular Hydroarylation of Alkynes

  摘要：

  The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity.

  DOI：

  10.1021/ja103080d

文献信息

• Rhodium(III)-Catalyzed Intermolecular Hydroarylation of Alkynes
  作者：Derek J. Schipper、Marieke Hutchinson、Keith Fagnou

  DOI：10.1021/ja103080d

  日期：2010.5.26

  The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity.