(4-methylquinolin-2-yloxy)acetic acid | 194659-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (4-methylquinolin-2-yloxy)acetic acid
• 英文别名: 4-methylquinolin-2-yloxyacetic acid；[(4-Methylquinolin-2-yl)oxy]acetic acid；2-(4-methylquinolin-2-yl)oxyacetic acid
• CAS: 194659-06-8
• 化学式: C₁₂H₁₁NO₃
• mdl: MFCD24390566
• 分子量: 217.224
• InChiKey: QTIVDAIRGTURPJ-UHFFFAOYSA-N

物化性质

• 沸点：
  397.4±27.0 °C(Predicted)
• 密度：
  1.291±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-氨基头孢烷酸 、 (4-methylquinolin-2-yloxy)acetic acid 在 aluminum oxide 作用下， 反应 0.03h， 以85%的产率得到7-((4'-methylquinolin-2'-yl-oxy)-acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  参考文献：
  名称：

  Microwave-Assisted Solid-Phase Synthesis of Cephalosporin Derivatives with Antibacterial Activity

  摘要：

  The reaction of heterocyclic acids with 7-amino-cephalosporanic acid adsorbed on basic alumina under microwave irradiation afforded the N-acylated cephalosporin analogues in satisfactory yield. All compounds were tested for their antibacterial activity; some of them showed significant antibacterial properties. Cefotaxime and cephalothin were used as reference drugs.

  DOI：

  10.1007/s007060070048
• 作为产物：
  描述：

  溴乙酸乙酯 、 2-羟基-4-甲基喹啉 在 aluminum oxide 作用下， 以 丙酮 为溶剂， 生成 (4-methylquinolin-2-yloxy)acetic acid
  参考文献：
  名称：

  Microwave-Assisted Solid-Phase Synthesis of Cephalosporin Derivatives with Antibacterial Activity

  摘要：

  The reaction of heterocyclic acids with 7-amino-cephalosporanic acid adsorbed on basic alumina under microwave irradiation afforded the N-acylated cephalosporin analogues in satisfactory yield. All compounds were tested for their antibacterial activity; some of them showed significant antibacterial properties. Cefotaxime and cephalothin were used as reference drugs.

  DOI：

  10.1007/s007060070048

文献信息

• Facile Synthesis of 2-Substituted Naphtho[2,1-b]pyran-3-ones using Microwaves†
  作者：Mazaahir Kidwai、Parven Kumar

  DOI：10.1039/a700516d

  日期：——

  2-Substituted naptho[2,1-b]pyran-3-ones have been synthesised by a novel one-pot method which involves cyclocondensation of 2-hydroxy-1-naphthaldehyde with 5-methyl-1,3,4-thiadiazol-2-ylsulfanyl-, 1H-1,2,3,4-tetrazol-1-yl-, 1H-indol-3-yl-, quinolin-8-yloxy- and 4-methylquinolin-2-yloxy-acetic acids in the presence of DCC–DMSO using microwaves as well as conventional heating.

  通过一种新颖的一锅法合成了 2-取代的萘并[2,1-b]吡喃-3-酮，该方法涉及 2-羟基-1-萘甲醛与 5-甲基-1,3,4-噻二唑-2-基硫酸的环缩合、 1H-1,2,3,4- 四唑-1-基-、1H-吲哚-3-基-、喹啉-8-基氧基-和 4-甲基喹啉-2-基氧基-乙酸的环缩合反应。
• Kidwai, Mazaahir; Kohli, Seema; Saxena, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 10, p. 963 - 964
  作者：Kidwai, Mazaahir、Kohli, Seema、Saxena、Gupta, Rani、Bardoo, Sapna

  DOI：——

  日期：——
• Microwave-Assisted Solid-Phase Synthesis of Cephalosporin Derivatives with Antibacterial Activity
  作者：Mazaahir Kidwai、Preeti Misra、Kumar R. Bhushan、Rajendra K. Saxena、Meena Singh

  DOI：10.1007/s007060070048

  日期：2000.9.22

  The reaction of heterocyclic acids with 7-amino-cephalosporanic acid adsorbed on basic alumina under microwave irradiation afforded the N-acylated cephalosporin analogues in satisfactory yield. All compounds were tested for their antibacterial activity; some of them showed significant antibacterial properties. Cefotaxime and cephalothin were used as reference drugs.