2,2,3,3,4,4,5,5-Octafluoro-6-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]hexan-1-ol | 1312809-33-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 2,2,3,3,4,4,5,5-Octafluoro-6-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]hexan-1-ol
• 英文别名: 2,2,3,3,4,4,5,5-octafluoro-6-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]hexan-1-ol
• CAS: 1312809-33-8
• 化学式: C₁₅H₂₄F₈O₆
• 分子量: 452.339
• InChiKey: LTBRBDQGFOBTJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  29
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  2,2,3,3,4,4,5,5-Octafluoro-6-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]hexan-1-ol 在 sodium azide 、 palladium 10% on activated carbon 、 氢气 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 287.5h， 生成 1-(16,16,17,17,18,18,19,19-octafluoro-2,5,8,11,14-pentaoxaicosan-20-yl)guanidine 2,2,2-trifluoroacetate
  参考文献：
  名称：

  Synthesis and phosphonate binding of guanidine-functionalized fluorinated amphiphiles

  摘要：

  We report herein convenient procedures for the use of highly fluorinated alpha,omega-diols (e.g. 1) as building blocks for the rapid assembly of amphiphilic materials containing a fluorous phase region. We describe expedient conversion of the parent diols to both symmetrically and asymmetrically substituted amphiphiles via the installation of an intermediate trifluoromethanesulfonyl ester. These sulfonate esters are versatile and easily manipulated intermediates, which can be readily converted to a variety of nitrogen, halogen, and carbon groups. Moreover, we show that for guanidine-terminated fluorous amphiphiles, these molecules can bind phosphonic acid groups in aqueous media. Thus, these materials offer a new strategy for decorating phosphorylated biomolecules with fluorine-rich coatings. (C) 2012 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2011.12.011
• 作为产物：
  描述：

  四乙基乙二醇单甲酯 在 吡啶 、 sodium hydride 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 62.5h， 生成 2,2,3,3,4,4,5,5-Octafluoro-6-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]hexan-1-ol
  参考文献：
  名称：

  Synthesis and phosphonate binding of guanidine-functionalized fluorinated amphiphiles

  摘要：

  We report herein convenient procedures for the use of highly fluorinated alpha,omega-diols (e.g. 1) as building blocks for the rapid assembly of amphiphilic materials containing a fluorous phase region. We describe expedient conversion of the parent diols to both symmetrically and asymmetrically substituted amphiphiles via the installation of an intermediate trifluoromethanesulfonyl ester. These sulfonate esters are versatile and easily manipulated intermediates, which can be readily converted to a variety of nitrogen, halogen, and carbon groups. Moreover, we show that for guanidine-terminated fluorous amphiphiles, these molecules can bind phosphonic acid groups in aqueous media. Thus, these materials offer a new strategy for decorating phosphorylated biomolecules with fluorine-rich coatings. (C) 2012 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2011.12.011

文献信息

• ULTRASOUND-ACTIVATED NANOPARTICLES AS IMAGING AGENTS AND DRUG DELIVERY VEHICLES
  申请人：Chang Andy Y.

  公开号：US20120277573A1

  公开（公告）日：2012-11-01

  The invention provides nanoparticles for delivery of imaging agents, drugs, and other molecules, such as genetic material. The nanoparticles have a core structure comprising the imaging agent and/or drug, and a shell structure that allows for water solubility. The shell structure further provides a barrier with limited water permeability that protects the core. The nanoparticles can be induced to release their cargo by treatment with ultrasound. Methods of delivering drugs and imaging agents are also provided, whereby the nanoparticles are delivered to tissues of interest in a substantially inert form, then activated using ultra-sound to release the drugs or imaging agents.

  这项发明提供了用于传递成像剂、药物和其他分子（如基因物质）的纳米颗粒。这些纳米颗粒具有核心结构，包括成像剂和/或药物，以及允许水溶性的外壳结构。外壳结构进一步提供了一个有限水渗透性的屏障，保护核心。可以通过超声治疗诱导纳米颗粒释放其载荷。还提供了传递药物和成像剂的方法，其中纳米颗粒以基本惰性的形式传递到感兴趣的组织中，然后使用超声激活以释放药物或成像剂。
• US9273184B1
  申请人：——

  公开号：US9273184B1

  公开（公告）日：2016-03-01