r-1-hydroxy-2-cis-methyl-3-trans-hydroxycyclohexane | 119138-62-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: r-1-hydroxy-2-cis-methyl-3-trans-hydroxycyclohexane
• 英文别名: r-1-hydroxy-2-trans-methyl-3-cis-hydroxycyclohexane；r-1-hydroxy-2-cis-methyl-3-cis-hydroxycyclohexane；2-methyl cyclohexane-1,3-diol；2-methyl-1,3-cyclohexanediol；2-Methylcyclohexane-1,3-diol
• CAS: 119138-62-4
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: ZFZLJTQEQCBDEB-UHFFFAOYSA-N

物化性质

• 熔点：
  206 °C(Solv: benzene (71-43-2))
• 沸点：
  252.9±8.0 °C(Predicted)
• 密度：
  1.081±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  r-1-hydroxy-2-cis-methyl-3-trans-hydroxycyclohexane 在 对甲苯磺酸 作用下， 以 乙醇 、 苯 为溶剂， 反应 1.5h， 以32%的产率得到9-syn-methyl-2,4-dioxabicyclo<3.3.1>nonane
  参考文献：
  名称：

  一些2,4-二氧杂-和2,4-二氧杂-3-硅双环[3.3.1]壬烷的合成与构象

  摘要：

  通过13 C和1 H NMR光谱确定的标题化合物的构象表明，双环[3.3.1]壬烷中的2-和4-亚甲基被醚氧原子取代会严重破坏cc的构象：在2-oxabicyclocyclo [ 3.3.1]-壬烷的cc和bc构象异构体大约相等，而在2,4-二恶双环[3.3.1]壬烷中，bc的构象占优势。的2,4-二氧杂-3- silabicyclo [3.3.1]壬烷还主要发生在矿井BC构象。与碳环双环[3.3.1]壬烷一样，两翼都被强烈展平。描述了立体选择性合成的3α-甲基双环[3.3.1]壬烷，这项研究中的重要模型化合物。

  DOI：

  10.1016/0040-4020(82)80072-0
• 作为产物：
  描述：

  2-甲基-1,3-环己二酮 在 镍 氢气 作用下， 120.0 ℃ 、10.13 MPa 条件下， 生成 r-1-hydroxy-2-cis-methyl-3-trans-hydroxycyclohexane
  参考文献：
  名称：

  一些甲基取代的2,4-二氧杂双环[3.3.1]壬烷的构型和构象

  摘要：

  制备了三种二甲基和一种三甲基 2,4-二氧杂双环 [3.3.1] 壬烷，并通过多核高场 NMR 光谱确定了它们的构型和构象。即使在 400 MHz 下，质子光谱也非常简并，以至于必须使用几个 2D 实验以及氘核磁共振来进行光谱分析。还报道了 13C 和 17O NMR 谱。获得的信息表明，其中两个二甲基衍生物具有 3α9syn 和 3α6α 构型的船椅构象，而第三个二甲基和三甲基衍生物存在于具有 3β9syn 和 3β9syn9anti 构型的椅椅构象中。

  DOI：

  10.1002/mrc.1260260618

文献信息

• Salt suitable for an acid generator and a chemically amplified positive resist composition containing the same
  申请人：Harada Yukako

  公开号：US20080081293A1

  公开（公告）日：2008-04-03

  The present invention provides a salt represented by the formula (I): wherein P 1 , P 2 and P 3 each independently represent a C1-C30 alkyl group which may be substituted with at least one selected from a hydroxyl group, a C3-C12 cyclic hydrocarbon group and a C1-C12 alkoxy group, or a C3-C30 cyclic hydrocarbon group which may be substituted with at least one selected from a hydroxyl group and a C1-C12 alkoxy group, provided that all of P 1 , P 2 and P 3 are not simultaneously phenyl groups which may be substituted, Q 1 and Q 2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, and R represents a group represented by the formula: wherein A 1 represents —OH or —Y 1 —OH, n represents an integer of 1 to 9, and Y 1 represents a divalent C1-C6 saturated aliphatic hydrocarbon group; a group represented by the formula: wherein ring X 1 represents a C3-C30 monocyclic or polycyclic hydrocarbon group in which one —CH 2 — group is substituted with —CO—, and at least one hydrogen atom in the monocyclic or polycyclic hydrocarbon group may be substituted with a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C4 perfluoroalkyl group, a C1-C6 hydroxyalkyl group, a hydroxyl group or a cyano group; a group represented by the formula: wherein ring X 2 represents a C3-C30 monocyclic or polycyclic hydrocarbon group in which a hydrogen atom of one —CH 2 — group is substituted with a hydroxyl group, and at least one hydrogen atom in the monocyclic or polycyclic hydrocarbon group may be substituted with a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C4 perfluoroalkyl group, a C1-C6 hydroxyalkyl group, a hydroxyl group or a cyano group; a group represented by the formula: wherein ring X 3 represents a C3-C30 monocyclic or polycyclic hydrocarbon group in which one —CH 2 — group is substituted with —COO—, and at least one hydrogen atom in the monocyclic or polycyclic hydrocarbon group may be substituted with a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C4 perfluoroalkyl group, a C1-C6 hydroxyalkyl group, a hydroxyl group or a cyano group, and m represents an integer of 0 to 12; or a group represented by the formula: wherein ring X 4 represents a C6-C30 polycyclic hydrocarbon group having tricycle or more, and at least one hydrogen atom in the polycyclic hydrocarbon group may be substituted with a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C4 perfluoroalkyl group, a C1-C6 hydroxyalkyl group or a cyano group, and l represents an integer of 1 to 12. The present invention further provides a chemically amplified resist composition comprising the salt represented by the above-mentioned formula (I).

  本发明提供了一种盐，其表示为公式（I）：其中P1、P2和P3各自独立地表示一个C1-C30烷基基团，该基团可以被至少一个羟基、一个C3-C12环烃基团和一个C1-C12烷氧基中的至少一个取代，或者一个C3-C30环烃基团，该基团可以被至少一个羟基和一个C1-C12烷氧基中的至少一个取代，前提是P1、P2和P3均不同时为可以被取代的苯基；Q1和Q2各自独立地表示氟原子或者C1-C6全氟烷基基团，R表示由以下公式表示的一个基团：其中A1表示—OH或—Y1—OH，n表示1到9之间的整数，Y1表示二价的C1-C6饱和脂肪族碳氢基团；一个由以下公式表示的基团：其中环X1表示一个C3-C30的单环或多环碳氢基团，其中一个—CH2—基团被—CO—取代，并且单环或多环碳氢基团中的至少一个氢原子可以被C1-C6烷基基团、C1-C6烷氧基、C1-C4全氟烷基基团、C1-C6羟基烷基基团、羟基或氰基取代；一个由以下公式表示的基团：其中环X2表示一个C3-C30的单环或多环碳氢基团，其中一个—CH2—基团的氢原子被羟基取代，并且单环或多环碳氢基团中的至少一个氢原子可以被C1-C6烷基基团、C1-C6烷氧基、C1-C4全氟烷基基团、C1-C6羟基烷基基团、羟基或氰基取代；一个由以下公式表示的基团：其中环X3表示一个C3-C30的单环或多环碳氢基团，其中一个—CH2—基团被—COO—取代，并且单环或多环碳氢基团中的至少一个氢原子可以被C1-C6烷基基团、C1-C6烷氧基、C1-C4全氟烷基基团、C1-C6羟基烷基基团、羟基或氰基取代，m表示0到12之间的整数；或者一个由以下公式表示的基团：其中环X4表示一个具有三环或更多的C6-C30多环碳氢基团，多环碳氢基团中的至少一个氢原子可以被C1-C6烷基基团、C1-C6烷氧基、C1-C4全氟烷基基团、C1-C6羟基烷基基团或氰基取代，l表示1到12之间的整数。本发明还提供了一种化学增感抗蚀组合物，其包含上述公式（I）表示的盐。
• Pyridin-2-YL-Amino-1, 2, 4-Thiadiazole Derivatives as Glucokinase Activators for the Treatment of Diabetes Mellitus
  申请人：Aicher Thomas Daniel

  公开号：US20100204240A1

  公开（公告）日：2010-08-12

  Provided are compounds of Formula (I): wherein R 2 , R 3 , R 13 , L and D 2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

  提供的化合物式(I)如下：其中R2、R3、R13、L和D2如规范中所定义，这些化合物可用于治疗和/或预防由于葡萄糖激酶活性不足引起或可以通过激活葡萄糖激酶治疗的疾病或紊乱，包括但不限于糖尿病、糖耐量受损、IFG（空腹血糖受损）和IFG（空腹高血糖），以及本文所讨论的其他疾病和紊乱。
• Mixture which can be thermally hardened and hardened by actinic radiation and use thereof
  申请人：——

  公开号：US20040053159A1

  公开（公告）日：2004-03-18

  A mixture curable thermally and with actinic radiation, comprising (A) a binder free from carbon-carbon double bonds activatable with actinic radiation, comprising at least one (meth)acrylate copolymer containing on average per molecule at least one isocyanate-reactive functional group and having a glass transition temperature Tg of from −40 to +80° C., (B) at least one blocked and/or unblocked polyisocyanate having at least one soft, flexibilizing segment, which as a constituent of three-dimensional polymeric networks lowers their glass transition temperature Tg, and (C) at least one unsaturated polyfunctional urethane which is free from isocyanate-reactive functional groups and contains on average per molecule more than four carbon-carbon double bonds activatable with actinic radiation and at least one hardening segment, the hardening segment as a constituent of three-dimensional polymer networks increasing their glass transition temperature Tg; processes for preparing it and its use.

  一种可通过热固化和光辐射固化的混合物，包括 (A) 不含碳碳双键的粘结剂，可通过辐射活化，包括至少一种（甲基）丙烯酸 酯共聚物，平均每个分子含有至少一个异氰酸酯反应官能团，玻璃化温度 Tg 为 -40 至 80 摄氏度、 (B) 至少一种封端和/或未封端的多异氰酸酯，该多异氰酸酯至少有一个柔软的柔 化段，作为三维聚合物网络的成分，可降低其玻璃化转变温度 Tg，以及 (C) 至少一种不饱和多官能度聚氨酯，该聚氨酯不含异氰酸酯反应官能团，每 个分子平均含有四个以上可被辐射活化的碳碳双键和至少一个硬化段，该硬化 段作为三维聚合物网络的组成成分可提高其玻璃化转变温度 Tg； 制备工艺及其用途。
• Coating materials which can be cured thermally and by means of acting radiation, use and method for the production thereof
  申请人：——

  公开号：US20040138389A1

  公开（公告）日：2004-07-15

  Coating materials curable thermally and with actinic radiation, comprising (A) at least one binder containing isocyanate-reactive functional groups and (B) a crosslinking component comprising (i) free and/or blocked isocyanate groups, (ii) reactive functional groups containing at least one bond which can be activated with actinic radiation, (iii) flexibilizing segments which as part of three-dimensional networks lower their glass transition temperature Tg, and (iv) hardening segments which as part of three-dimensional networks raise their glass transition temperature Tg; with the proviso that the crosslinking component (B) comprises or consists of at least one constituent which has the features (i) and (ii); processes for their preparation, and their use.

  可通过热固化和光辐射固化的涂层材料，包括 (A) 至少一种含有异氰酸酯反应官能团的粘合剂和 (B) 交联组分，包括 (i) 游离和/或封端异氰酸酯基团、 (ii) 反应性官能团，其中至少含有一个可被光辐射活化的键、 (iii) 柔化段，作为三维网络的一部分，可降低其玻璃化转变温度 Tg，和 (iv) 硬化段，作为三维网络的一部分，可提高其玻璃化转变温度 Tg； 但交联组分（B）至少包括一种具有（i）和（ii）特征的成分； 其制备工艺及其用途。
• Efficient Ruthenium-Catalyzed Transfer Hydrogenation/Hydrogenation of 1,3-Cycloalkanediones to 1,3-Cycloalkanediols Using Microwave Heating
  作者：Karin Leijondahl、Ann-Britt L. Fransson、Jan-E. Bäckvall

  DOI：10.1021/jo0612527

  日期：2006.10.1

  A number of 1,3-cycloalkanediones were efficiently reduced to the corresponding diols in good yield by the use of a ruthenium catalyst, 2-propanol, and hydrogen gas under microwave heating.