Menthon

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Menthon
• 英文别名: (5S)-5-methyl-2-propan-2-ylcyclohexan-1-one
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: NFLGAXVYCFJBMK-IENPIDJESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE<br/>[FR] NOUVELLES SPIRO-IMIDAZOLONES EN TANT QU'ANTAGONISTES DE RÉCEPTEUR DE GLUCAGON, COMPOSITIONS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2011119559A1

  公开（公告）日：2011-09-29

  The present invention relates to compounds of the general formula: wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

  本发明涉及一般式化合物，其中环A、环B、R1、R3、Z、L1和L2彼此独立选择，并如本文所定义，涉及包含该化合物的组合物，以及使用该化合物作为胰高血糖素受体拮抗剂以及用于治疗或预防2型糖尿病及相关疾病的方法。
• NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE
  申请人：Wong Michael K.

  公开号：US20130012434A1

  公开（公告）日：2013-01-10

  The present invention relates to compounds of the general formula: wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

  本发明涉及通式化合物：其中环A、环B、R1、R3、Z、L1和L2是彼此独立选择并如下所定义的，以及包含该化合物的组合物，以及使用该化合物作为胰高血糖素受体拮抗剂以及治疗或预防2型糖尿病及相关疾病的方法。
• Method of preparing sample for crystal structure analysis, method of determining absolute configuration of chiral compound, and polynuclear metal complex monocrystal
  申请人：The University of Tokyo

  公开号：US10309035B2

  公开（公告）日：2019-06-04

  Method for preparing a crystal structure analysis sample for determining an absolute configuration of a chiral compound includes bringing a single crystal of a porous compound into contact with a solvent solution that contains a chiral compound, the single crystal of the porous compound including a three-dimensional framework, and either or both of pores and voids that are defined by the three-dimensional framework, and are three-dimensionally arranged in an ordered manner, the three-dimensional framework being formed by one molecular chain or two or more molecular chains, or formed by one molecular chain or two or more molecular chains, and a framework-forming compound, and comprising a chiral substituent of which the absolute configuration is known, the crystal structure analysis sample having a structure in which molecules of the chiral compound are arranged in either or both of the pores and the voids of the single crystal in an ordered manner.

  制备用于确定手性化合物绝对构型的晶体结构分析样品的方法包括使多孔化合物的单晶体与含有手性化合物的溶剂溶液接触，多孔化合物的单晶体包括三维框架，以及由三维框架限定的孔隙和空隙中的一个或两个，并以有序的方式三维排列、三维框架由一条分子链或两条或两条以上的分子链形成，或由一条分子链或两条或两条以上的分子链和框架形成化合物形成，并包含绝对构型已知的手性取代基，晶体结构分析样品具有手性化合物分子以有序方式排列在单晶体的孔隙和空隙中的任一者或两者中的结构。
• RUTHENIUM-PHENOL CATALYSTS FOR TRANSFER HYDROGENATION REACTIONS
  申请人：BASF SE

  公开号：EP3113879B1

  公开（公告）日：2018-04-18
• METHOD FOR PRODUCING MENTHONES FROM ISOPULEGOL IN THE GAS PHASE
  申请人：BASF SE

  公开号：US20170066705A1

  公开（公告）日：2017-03-09

  The present invention relates to a process for reacting isopulegol to menthone in the gas phase and to the use of the reaction products thus prepared as additives in foods, cosmetics, pharmaceutical products, tobacco formulations, household products, and laundry care products.