ethyl 3-(5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)propanoate | 210540-54-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 3-(5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)propanoate
• 英文别名: Ethyl 3-(5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)propanoate；ethyl 3-[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]propanoate
• CAS: 210540-54-8
• 化学式: C₁₂H₁₇NO₄
• 分子量: 239.271
• InChiKey: MBYMGNSMTMFPTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 3-(5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)propanoate 在 manganese dioxide 氮气 、 n-hexanes ethyl acetate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以to obtain solid form of Ethyl 3-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)propanoate (12) as the target substance (yield: 71.1%)的产率得到ethyl 3-(4-formyl-5-hydroxy-6-methylpyridin-3-yl)propanoate
  参考文献：
  名称：

  NOVEL PYRIDINE CARBOXYLIC ACID BASED COMPOUND USED AS A P2X1 AND P2X3 RECEPTOR ANTAGONIST, A PRODUCTION METHOD FOR THE SAME AND A COMPOSITION COMPRISING THE SAME

  摘要：

  本发明提供了一种新型的以吡啶羧酸为基础的化合物，用作P2X1和P2X3受体拮抗剂，以及其制备方法和包含该化合物的组合物。根据本发明，该化合物是P2X1和P2X3受体的强效拮抗剂，因此可用作治疗或预防涉及神经性疼痛或慢性炎症疾病的药物，这些疾病是由P2X1和P2X3受体活性引起的。

  公开号：

  US20130040997A1
• 作为产物：
  描述：

  2-甲基-3-羟基-4,5-二羟甲基吡啶 在 重铬酸吡啶 、 甲酸 、 palladium on activated charcoal 、 氢气 、 sodium hydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 mineral oil 为溶剂， 反应 8.58h， 生成 ethyl 3-(5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl)propanoate
  参考文献：
  名称：

  NOVEL PYRIDINE CARBOXYLIC ACID BASED COMPOUND USED AS A P2X1 AND P2X3 RECEPTOR ANTAGONIST, A PRODUCTION METHOD FOR THE SAME AND A COMPOSITION COMPRISING THE SAME

  摘要：

  提供了一种基于吡啶羧酸的新型化合物，用作P2X1和P2X3受体拮抗剂，以及该化合物的生产方法和包含该化合物的组合物。根据本发明的化合物是P2X1和P2X3受体的强效拮抗剂，因此可用作治疗或预防涉及神经疼痛或慢性炎症疾病的药物，这些疾病是由P2X1和P2X3受体活性引起的疾病。

  公开号：

  US20130040997A1

文献信息

• Synthesis and structure–activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists
  作者：Kwan-Young Jung、Joong-Heui Cho、Jung Sun Lee、Hyo Jun Kim、Yong-Chul Kim

  DOI：10.1016/j.bmc.2013.01.073

  日期：2013.5

  Carboxylic acid derivatives of pyridoxal were developed as potent P2X(1) and P2X(3) receptor antagonists with modifications of a lead compound, pyridoxal-5'-phosphate-6-azophenyl-2',5'-disulfonate (5b, iso-PPADS). The designing strategies included the modifications of aldehyde, phosphate or sulfonate groups of 5b, which may be interacted with lysine residues of the receptor binding pocket, to weak anionic carboxylic acid groups. The corresponding carboxylic acid analogs of pyridoxal-5'-phosphate (1), 13 and 14, showed parallel antagonistic potencies. Also, most of 6-azophenyl derivatives (24-28) of compound 13 or 14 showed potent antagonistic activities similar to that of 5b at human P2X(3) receptors with 100 nM range of IC50 values in two-electrode voltage clamp (TEVC) assay system on the Xenopus oocyte. The results indicated that aldehyde and phosphoric or sulfonic acids in 5b could be changed to a carboxylic acid without affecting antagonistic potency at mouse P2X(1) and human P2X(3) receptors. (C) 2013 Elsevier Ltd. All rights reserved.
• US9546139B2
  申请人：——

  公开号：US9546139B2

  公开（公告）日：2017-01-17
• NOVEL PYRIDINE CARBOXYLIC ACID BASED COMPOUND USED AS A P2X1 AND P2X3 RECEPTOR ANTAGONIST, A PRODUCTION METHOD FOR THE SAME AND A COMPOSITION COMPRISING THE SAME
  申请人：Kim Yong-Chul

  公开号：US20130040997A1

  公开（公告）日：2013-02-14

  Provided are a novel pyridine carboxylic acid based compound used as a P2X 1 and P2X 3 receptor antagonist, a production method for the same and a composition comprising the same. The compound according to the present invention is a powerful antagonist of P2X 1 and P2X 3 receptors, and hence can be used as a drug for treating or preventing diseases involving neurological pain or chronic inflammatory diseases which are diseases caused by P2X 1 and P2X 3 receptor activity.

  提供了一种基于吡啶羧酸的新型化合物，用作P2X1和P2X3受体拮抗剂，以及该化合物的生产方法和包含该化合物的组合物。根据本发明的化合物是P2X1和P2X3受体的强效拮抗剂，因此可用作治疗或预防涉及神经疼痛或慢性炎症疾病的药物，这些疾病是由P2X1和P2X3受体活性引起的疾病。