5-hydroxy-1-cyclooctene | 1104620-66-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-hydroxy-1-cyclooctene
• 英文别名: cyclo-oct-4-en-1-ol；5-hydroxycyclooct-1-ene；Cyclooct-4-en-1-ol
• CAS: 1104620-66-7
• 化学式: C₈H₁₄O
• mdl: MFCD06252442
• 分子量: 126.199
• InChiKey: UCPDHOTYYDHPEN-UHFFFAOYSA-N

物化性质

• 沸点：
  202.2±29.0 °C(Predicted)
• 密度：
  0.954±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-hydroxy-1-cyclooctene 在 苯甲酸甲酯 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 0.5h， 以200 mg的产率得到(E)-cyclooct-4-enol
  参考文献：
  名称：

  反式环辛烯四嗪连接制备小分子微阵列及其在溴结构域蛋白-蛋白质相互作用抑制剂高通量筛选中的应用

  摘要：

  快速高效：通过使用已知最快的生物正交反应，将反式环辛烯（TCO）修饰的小分子文库固定在四嗪功能化的载玻片上。针对各种人类溴结构域筛选了所得的小分子微阵列，以鉴定蛋白质-蛋白质相互作用抑制剂。

  DOI：

  10.1002/anie.201307803
• 作为产物：
  描述：

  1,5-cis,cis-cyclooctadiene 在 二异丁基氢化铝 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 氯仿 、 甲苯 为溶剂， 反应 38.5h， 生成 5-hydroxy-1-cyclooctene
  参考文献：
  名称：

  Enhancing Mechanical Performance of a Covalent Self-Healing Material by Sacrificial Noncovalent Bonds

  摘要：

  Polymers that repair themselves after mechanical damage can significantly improve their durability and safety. A major goal in the field of self-healing materials is to combine robust mechanical and efficient healing properties. Here, we show that incorporation of sacrificial bonds into a self-repairable network dramatically improves the overall mechanical properties. Specifically, we use simple secondary amide side chains to create dynamic energy dissipative hydrogen bonds in a covalently cross-linked polymer network, which can self-heal via olefin cross-metathesis. We envision that this straightforward sacrificial bonding strategy can be employed to improve mechanical properties in a variety of self-healing systems.

  DOI：

  10.1021/jacs.5b01601

文献信息

• Bridged metallocene catalysts with a pendant group 13 element, catalyst systems containing same, processes for making a polymer product using same, and products made from same
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US10851187B2

  公开（公告）日：2020-12-01

  A metallocene catalyst compound can comprise a structure represented by formula (F-MC) below comprising a first cyclopentadienyl ring with carbon atoms directly connected with R1, R2, R4, and R5, and a second cyclopentadienyl ring with carbon atoms directly connected with R10, R11, R12, and R13, and a bridging group (BG) directly connecting the first and second cyclopentadienyl rings A catalyst system can include the metallocene compound, a non-coordinating anion type activator comprising a supported alumoxane or aluminum alkyl, and optionally a scavenger. A process for making a polymeric product can comprise: contacting a C2-C22 alpha-olefin feed with the catalyst system to obtain a polymerization reaction mixture; and obtaining a polymer product from the polymerization reaction mixture. A polymer product can be made by the process to exhibit at least an Mn from 7000 g/mol to 70000 g/mol and a PDI from 4.1 to 9.0.

  一种茂金属催化剂化合物可以包括以下由下式（F-MC）表示的结构，其中包括第一个环戊二烯基环，其碳原子直接连接到R1、R2、R4和R5，以及第二个环戊二烯基环，其碳原子直接连接到R10、R11、R12和R13，以及直接连接第一个和第二个环戊二烯基环的桥接基团（BG）。 催化剂体系可以包括茂金属化合物，一种非配位阴离子型活化剂，包括支撑的氧化铝烷氧化物或铝烷基，以及可选的清除剂。制备聚合物产品的方法可以包括：将C2-C22α-烯烃原料与催化剂体系接触，以获得聚合反应混合物；并从聚合反应混合物中获得聚合物产品。通过该方法可以制备聚合物产品，其至少具有从7000克/摩尔到70000克/摩尔的Mn和从4.1到9.0的PDI。
• Phenoxyimine-Based Complexes and Related Ring-Opening Metathesis Polymerization Methods
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20210061832A1

  公开（公告）日：2021-03-04

  Phenoxyimine-based complexes, when activated, are suitable for catalyzing ring-opening metathesis polymerization (ROMP) reactions of cyclopentene and a comonomer under mild reaction conditions, for example, at reaction temperatures of about −196° C. and about 70° C. in diluents like toluene. The use of such activated phenoxyimine-based complexes may favor polymer products with a high cis-content.

  基于苯氧亚胺的配合物在激活后适合于在温和的反应条件下催化环戊烯和共单体的开环易位聚合（ROMP）反应，例如，在如甲苯这样的稀释剂中，反应温度大约为-196°C和大约70°C。使用这种激活的基于苯氧亚胺的配合物可能会倾向于产生高顺式含量的聚合物产品。
• TETRAZINE-BASED BIO-ORTHOGONAL COUPLING REAGENTS AND METHODS
  申请人：Fox Joseph Michael

  公开号：US20090023916A1

  公开（公告）日：2009-01-22

  Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and/or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.

  耦合反应，适用于有机或水性介质，通过将1,2,4,5-四唑与二烯丙烯发生反应来进行。二烯丙烯可能与蛋白质共价结合，耦合反应可在含有细胞或细胞裂解产物的生物介质中进行。这些反应可在存在主要胺基、硫醇、乙炔、叠氮化物、膦化合物以及Staudinger和/或Sharpless-Huisgen反应产物的情况下进行。新颖的3-取代环丙烯化合物和反式-环辛烯是这些反应的优秀二烯丙烯。
• NOVEL PHOSPHOR-TETRAZINE COMPOUND AND USE THEREOF
  申请人：Spark Biopharma, Inc.

  公开号：US20210198260A1

  公开（公告）日：2021-07-01

  The present invention relates to a novel phosphor-tetrazine and a use thereof and, more particularly, provides a novel compound having high fluorescence amplification efficiency in various wavelength ranges by using a compound having a novel core skeleton called tert-butyl (3-(7-(6-methyl-1,2,4,5-tetrazin-3 -yl)-3-oxo-9-phenyl-1H-pyrrolo[3,4-b]indolizin-2(3H)-yl)propyl)carbamate.

  本发明涉及一种新型磷光-四唑及其用途，更具体地提供了一种通过使用一种名为叔丁基(3-(7-(6-甲基-1,2,4,5-四唑-3-基)-3-氧代-9-苯基-1H-吡咯并[3,4-b]吲哚啉-2(3H)-基)丙基)氨基甲酸酯的新型核心骨架具有高荧光增强效率的新化合物。
• Group 6 transition metal catalyst compound and use thereof
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US10329363B2

  公开（公告）日：2019-06-25

  This invention relates to a catalyst system comprising a half sandwich chromocene compound featuring a tethered P-donor, with an activator and optional supportation on silica which produces ethylene homopolymer or copolymer.

  这项发明涉及一种催化剂系统，包括一种半夹心基铬环戊二烯化合物，具有一个带有P-供体的连接物，与一个活化剂和可选的硅胶支撑物一起，可以产生乙烯均聚物或共聚物。