7-bromo-8-hydroxy-quinoline-5-carbaldehyde | 98948-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-bromo-8-hydroxy-quinoline-5-carbaldehyde
• 英文别名: 7-Brom-8-hydroxy-chinolin-5-carbaldehyd；7-Bromo-8-hydroxyquinoline-5-carbaldehyde
• CAS: 98948-93-7
• 化学式: C₁₀H₆BrNO₂
• 分子量: 252.067
• InChiKey: OQXAYWFNXOKSOG-UHFFFAOYSA-N

物化性质

• 沸点：
  388.6±37.0 °C(Predicted)
• 密度：
  1.761±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-(2,2,2-trichloro-1-hydroxy-ethyl)-quinolin-8-ol 在 甲醇 、 溴 、 sodium methylate 、 溶剂黄146 作用下， 生成 7-bromo-8-hydroxy-quinoline-5-carbaldehyde
  参考文献：
  名称：

  Condensation of Chloral Hydrate with 8-Quinolinol

  摘要：

  DOI：

  10.1021/ja01629a098

文献信息

• Bromine-Lithium exchange on bromo-8-hydroxyquinolines via formation of their sodium salts
  作者：Florence Mongin、Jean-Marie Fourquez、Stéphanie Rault、Vincent Levacher、Alain Godard、François Trécourt、Guy Quéguiner

  DOI：10.1016/0040-4039(95)01776-e

  日期：1995.11

  A short and versatile method is reported for the preparation of 8-hydroxyquinoline derivatives by reaction of n-butyllithium with 5,7-dibromo-8-hydroxyquinoline 2 and 7-bromo-8-hydroxyqumoline 1 as their sodium salts. Thus, bromine-lithium exchange reaction on compound 2, highly regioselective, gave after addition of various electrophiles, 5-substituted 7-bromo-8-hydroxyquinolines 4a-j in moderate

  据报道，通过使正丁基锂与作为钠盐的5,7-二溴-8-羟基喹啉2和7-溴-8-羟基喹啉1反应，制备8-羟基喹啉衍生物的一种短而通用的方法。因此，在区域2上具有高区域选择性的溴-锂交换反应在添加各种亲电试剂后以中等至良好的产率产生了5-取代的7-溴-8-羟基喹啉4a-j。相同的方法也适用于产生7-取代的8-羟基喹啉3a-b的7-溴-8-羟基喹啉1。
• Alkylidene pyrazolidinedione derivatives
  申请人：——

  公开号：US20040220188A1

  公开（公告）日：2004-11-04

  The present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) for the treatment and/or prevention of diabetes type I and/or II, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity and polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel alkylidene pyrazolidinedione derivatives. (I) R1 and R2 represent independently from each other an unsubstituted or substituted aryl or heteroaryl. 1

  本发明涉及使用式(I)的烷基亚甲基吡唑啉二酮衍生物治疗和/或预防糖尿病I型和/或II型、糖耐量受损、胰岛素抵抗、高血糖、肥胖症和多囊卵巢综合症（PCOS）。特别是，本发明涉及使用式(I)的烷基亚甲基吡唑啉二酮衍生物调节，特别是抑制PTPs的活性，尤其是PTP1B、TC-PTP、SHP和GLEPP-1的活性。本发明还涉及新的烷基亚甲基吡唑啉二酮衍生物。(I)中，R1和R2各自独立地表示未取代或取代的芳基或杂环芳基。
• ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1399156A2

  公开（公告）日：2004-03-24
• [EN] ALKYLIDENE PYRAZOLIDINEDIONE DERIVATIVES<br/>[FR] DERIVES D'ALKYLIDENE PYRAZOLIDINEDIONE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2002102359A2

  公开（公告）日：2002-12-27

  The present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) for the treatment and/or prevention of diabetes type I and/or II, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity and polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel alkylidene pyrazolidinedione derivatives. (I) R1 and R2 represent independently from each other an unsubstituted or substituted aryl or heteroaryl.
• Condensation of Chloral Hydrate with 8-Quinolinol
  作者：Konomu Matsumura、Motoko Ito

  DOI：10.1021/ja01629a098

  日期：1955.12