(6-bromo-4-methylbenzothiazol-2-yl)-4-(4-chlorophenyl)-7,7-dimethyl-3,4,7,8-tetrahydro-6H-quinoline-2,5-dione | 1403156-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (6-bromo-4-methylbenzothiazol-2-yl)-4-(4-chlorophenyl)-7,7-dimethyl-3,4,7,8-tetrahydro-6H-quinoline-2,5-dione
• 英文别名: 1-(6-Bromo-4-methyl-1,3-benzothiazol-2-yl)-4-(4-chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydroquinoline-2,5-dione；1-(6-bromo-4-methyl-1,3-benzothiazol-2-yl)-4-(4-chlorophenyl)-7,7-dimethyl-3,4,6,8-tetrahydroquinoline-2,5-dione
• CAS: 1403156-06-8
• 化学式: C₂₅H₂₂BrClN₂O₂S
• 分子量: 529.885
• InChiKey: YVTXEAYTDNFHIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  78.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 6-bromo-4-methylbenzo[d]thiazol-2-amine 、 4-氯苯甲醛 、 5,5-二甲基-1,3-环己二酮 在 氨基磺酸 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以92%的产率得到(6-bromo-4-methylbenzothiazol-2-yl)-4-(4-chlorophenyl)-7,7-dimethyl-3,4,7,8-tetrahydro-6H-quinoline-2,5-dione
  参考文献：
  名称：

  A domino protocol for the efficient synthesis of structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues

  摘要：

  Structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues have been synthesized by an environmentally benign efficient and convenient synthetic method involving sulfamic acid catalyzed one-pot four-component reaction of Meldrum acid, 2-aminobenzothiazoles, dimedone, and isat-in/carbonyl compound. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.08.099

文献信息

• A domino protocol for the efficient synthesis of structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues
  作者：Anand Kumar Arya、Sunil Kumar Gupta、Mahendra Kumar

  DOI：10.1016/j.tetlet.2012.08.099

  日期：2012.11

  Structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues have been synthesized by an environmentally benign efficient and convenient synthetic method involving sulfamic acid catalyzed one-pot four-component reaction of Meldrum acid, 2-aminobenzothiazoles, dimedone, and isat-in/carbonyl compound. (C) 2012 Elsevier Ltd. All rights reserved.