disopropyloxy disulfide | 3359-04-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: disopropyloxy disulfide
• 英文别名: diisopropoxy disulfide；diisopropoxy-disulfane；Diisopropyloxy-disulfid；1,2-Diisopropoxydisulfane；2-(propan-2-yloxydisulfanyl)oxypropane
• CAS: 3359-04-4
• 化学式: C₆H₁₄O₂S₂
• 分子量: 182.308
• InChiKey: LFLSKZBPJFHHKW-UHFFFAOYSA-N

物化性质

• 沸点：
  200.7±23.0 °C(Predicted)
• 密度：
  1.078±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.1
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  5,5-二甲基-1-吡咯啉-N-氧化物 、 disopropyloxy disulfide 生成
  参考文献：
  名称：

  Photolysis of Dialkoxy Disulfides:  A Convenient Source of Alkoxy Radicals for Addition to the Sphere of Fullerene C₆₀

  摘要：

  Photolysis of dialkoxy disulfides ROSSOR (R = Me, Et, i-Pr, t-Bu, i-PrCH2, t-BuCH(2)) yields the radicals RO(.), ROS(.), and ROS(.)=O that were identified on the basis of product analysis and spin trapping techniques. It has been shown that only the alkoxy radicals RO(.), produced from ROSSOR, add to the sphere of fullerene C-60 in steady state conditions to yield the RO-C-60(.) adducts which can be detected by ESR spectroscopy. The different trend of the hydrogen splitting constants in the RO-C-60(.) with respect to the corresponding RS-C-60(.) adducts previously reported has been interpreted as a consequence of the different C-O and C-S bond lengths.

  DOI：

  10.1021/jo952169e
• 作为产物：
  描述：

  异丙醇 在 二氯化二硫 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 disopropyloxy disulfide
  参考文献：
  名称：

  Organic Esters of Bivalent Sulfur. I. Dialkoxy Disulfides

  摘要：

  DOI：

  10.1021/jo01019a044
• 作为试剂：
  描述：

  1-硫代-b-D-葡萄糖四乙酸酯 在 disopropyloxy disulfide 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以11%的产率得到bis(2,3,4,6-tetra-O-acetyl-1-deoxy-β-D-glucopyranosyl)tetrasulfane
  参考文献：
  名称：

  Steudel, Ralf; Schmidt, Heinar, Chemische Berichte, 1994, vol. 127, # 7, p. 1219 - 1222

  摘要：

  DOI：

文献信息

• A Practical Synthesis of Mixed Allyl and Allenesulfinates
  作者：Samuel Braverman、Tatiana Pechenick

  DOI：10.1055/s-2003-41038

  日期：——

  by treatment of symmetrical dialkoxy disulfides (ROSSOR) with alcohols at room temperature has been found. Subsequent spontaneous [2,3]-sigmatropic rearrangements of mixed sulfoxylates such as alkyl allyl and alkyl propargyl sulfoxylates afford mixed alkyl allyl and alkyl allenesulfinates in good yield. The latter are not readily available by other routes.

  已经发现了一种通过在室温下用醇处理对称二烷氧基二硫化物 (ROSSOR) 来制备混合次硫酸盐 (ROSOR') 的新的、通用的和有效的方法。随后的混合次硫酸盐（例如烷基烯丙基和烷基炔丙基次硫酸盐）的自发 [2,3]-σ 重排以良好的产率提供混合的烷基烯丙基和烷基丙二烯亚磺酸盐。后者不易通过其他途径获得。
• Antibacterial S-heterosubstituted disulfides
  申请人：Turos Edward

  公开号：US10350177B2

  公开（公告）日：2019-07-16

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

  合成衍生的 S,S-互二取代二硫化物对多种细菌（包括金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和土拉弗氏菌）具有强效的体外抗菌活性。本发明提供了有效治疗微生物/细菌感染的化合物、方法和组合物，特别是治疗对传统抗生素产生抗药性的细菌引起的感染。
• Reactions of alkyl or aryl chlorosulfites with thiocarboxylic acids
  作者：Hiroaki Kagami、Hikaru Satsumabayashi、Shinichi Motoki

  DOI：10.1021/jo00426a006

  日期：1977.3
• Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
  作者：Praveen Ramaraju、Danielle Gergeres、Edward Turos、Sonja Dickey、Daniel V. Lim、John Thomas、Burt Anderson

  DOI：10.1016/j.bmcl.2012.04.056

  日期：2012.6

  The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillinresistant S. aureus and F. tularensis. (C) 2012 Elsevier Ltd. All rights reserved.
• Schmidt, Heinar; Steudel, Ralf, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1990, vol. 45, # 4, p. 557 - 558
  作者：Schmidt, Heinar、Steudel, Ralf

  DOI：——

  日期：——