(2R,3R,4R,5R)-4,5-dimethoxyoxane-2,3-diol | 911661-46-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4R,5R)-4,5-dimethoxyoxane-2,3-diol
• CAS: 911661-46-6
• 化学式: C₇H₁₄O₅
• 分子量: 178.185
• InChiKey: VFKPLVMGZRTHRG-MVIOUDGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3,4-三-O-乙酰基-α-D-木吡喃糖苷溴 在 sodium tetrahydroborate 、 硫酸 、 sodium methylate 、 四丁基碘化铵 、 sodium hydroxide 作用下， 以 甲醇 、 二甲基亚砜 、 乙腈 为溶剂， 反应 30.0h， 生成 O³,O⁴-dimethyl-α-D-xylopyranose 、 (2R,3R,4R,5R)-4,5-dimethoxyoxane-2,3-diol
  参考文献：
  名称：

  Synthesis and identification of cytotoxic diphyllin glycosides as vacuolar H+-ATPase inhibitors

  摘要：

  The concise syntheses of two natural diphyllin glycosides Cleistanthin-A (CA), Cleistanthoside-A (CleA) and its derivative, Cleistanthoside-A tetraacetate (CleT), have been achieved. They were evaluated for their in vitro anti-proliferative activities against MCF-7, HeLa, HepG2, HCT-116, U251 cancer cell lines by MTT assay. Both of CA and CleT were anti-proliferative to these cancer cells at nanomolar concentrations. They have been shown to inhibit the activity of vacuolar H+-ATPase (V-ATPase) in HepG2 cells and neutralize the pH of lysosomes at nanomolar concentrations. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.06.002

文献信息

• Transglutaminase activator
  申请人：Kao Corporation

  公开号：US10064800B2

  公开（公告）日：2018-09-04

  A transglutaminase activator containing at least one kind selected from the group consisting of an extract from Justicia procumbens, an extract from Peristrophe japonica, and a compound represented by Formula (1), as an active ingredient: wherein R1 and R2 represent a hydrogen atom, a hydroxyl group, or an alkoxy group having 1 to 4 carbon atoms; R3 represents a hydrogen atom, or a group for forming a methylenedioxy group by bonding with R2; R4 and R5 represent a hydrogen atom, or a group for forming a methylenedioxy group by bonding with each other; R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.

  一种转谷氨酰胺酶激活剂，其活性成分中至少含有一种从 Justicia procumbens 提取物、Peristrophe japonica 提取物和由式（1）代表的化合物组成的组中选出的物质： 其中 R1 和 R2 代表氢原子、羟基或具有 1 至 4 个碳原子的烷氧基；R3 代表氢原子或通过与 R2 键合形成亚甲二氧基的基团；R4 和 R5 代表氢原子或通过相互键合形成亚甲二氧基的基团；R6 代表氢原子、羟基、具有 1 至 5 个碳原子的烷氧基、具有 1 至 4 个碳原子的酰氧基或特定的糖残基。
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  公开号：EP2918280B1

  公开（公告）日：2019-04-10
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  申请人：Kikuchi Mamiko

  公开号：US20130295207A1

  公开（公告）日：2013-11-07

  Use of haguro-so or an organic solvent extract thereof, or a compound represented by the following formula (I) or a salt thereof, for inhibiting a dopa oxidase activity, for inhibiting melanin production, or for whitening the skin; in the formula (I), R 1 and R 2 , being the same or different, each represent a hydroxyl group, or a C 1-4 linear or branched alkoxy group, or R 1 and R 2 together form a methylenedioxy group; R 3 and R 4 , being the same or different, each represent a hydroxyl group, or a C 1-4 linear or branched alkoxy group, or R 3 and R 4 together form a methylenedioxy group; R 5 represents a hydrogen atom, a hydroxyl group, a C 1-5 linear or branched alkoxy group, a C 1-4 acyl group, or a sugar residue selected from the group consisting of (D-apio-β-D-furanosyl)oxy, (β-D-glucopyranosyl)oxy, (3-O,4-O-dimethyl-D-xylopyranosyl)oxy, (2-O,3-O,4-O-trimethyl-β-D-xylopyranosyl)oxy, and (3-O-methyl-β-D-glucopyranosyl)oxy; R 6 and R 7 are each a hydrogen atom and R 8 and R 9 together represent an oxygen atom, or R 8 and R 9 are each a hydrogen atom and R 6 and R 7 together represent an oxygen atom.
• Transglutaminase Activator
  申请人：Kao Corporation

  公开号：US20150238404A1

  公开（公告）日：2015-08-27

  A transglutaminase activator containing at least one kind selected from the group consisting of an extract from Justicia procumbens , an extract from Peristrophe japonica , and a compound represented by Formula (1), as an active ingredient: wherein R 1 and R 2 represent a hydrogen atom, a hydroxyl group, or an alkoxy group having 1 to 4 carbon atoms; R 3 represents a hydrogen atom, or a group for forming a methylenedioxy group by bonding with R 2 ; R 4 and R 5 represent a hydrogen atom, or a group for forming a methylenedioxy group by bonding with each other; R 6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.
• US9339454B2
  申请人：——

  公开号：US9339454B2

  公开（公告）日：2016-05-17